All Stories

  1. Tuning Down the Pain – An Overview of Allosteric Modulation of Opioid Receptors: Mechanisms of Modulation, Allosteric Sites, Modulator Syntheses
  2. The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases
  3. Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies
  4. Effects of the Positive Allosteric Modulator of Metabotropic Glutamate Receptor 5, VU-29, on Maintenance Association between Environmental Cues and Rewarding Properties of Ethanol in Rats
  5. Toxicity of Carlina Oxide—A Natural Polyacetylene from the Carlina acaulis Roots—In Vitro and in Vivo Study
  6. Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics
  7. New tirapazamine derivatives protect cardiomyocytes from doxorubicin toxicity
  8. Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins—In Silico Study
  9. The effect of statins on psoriasis severity: a meta-analysis of randomized clinical trials
  10. Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
  11. The Universal 3D QSAR Model for Dopamine D2 Receptor Antagonists
  12. Thyroid Peroxidase Activity is Inhibited by Phenolic Compounds—Impact of Interaction
  13. Role of N-terminus in function and dynamics of sirtuin 7: an in silico study
  14. In Vitro Evaluation of Sulforaphane and a Natural Analog as Potent Inducers of 5-Fluorouracil Anticancer Activity
  15. Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D2 Receptor Ligand
  16. Corrigendum to ‘Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line’ Food Chem Toxicol. 111 (2018) 1-8
  17. Potential Future of New Glutamate Agonists and Antagonists Development
  18. Molecular Modelling Approaches to Antibacterial Drug Design and Discovery
  19. Synthesis, Experimental and Computational Studies of N-(4-amino-6-oxo- 1,6-dihydropyrimidin-5-yl)benzamide
  20. Thermal and spectroscopic studies of 2,3,5-trisubstituted and 1,2,3,5-tetrasubstituted indoles as non-competitive antagonists of GluK1/GluK2 receptors
  21. Comparative molecular field analysis and molecular dynamics studies of the dopamine D2 receptor antagonists without a protonatable nitrogen atom
  22. Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line
  23. Protein–Protein Docking in Drug Design and Discovery
  24. Molecular mechanisms of allosteric probe dependence in μ opioid receptor
  25. Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs
  26. Application of Raman spectroscopy for direct analysis of Carlina acanthifolia subsp. utzka root essential oil
  27. The influence of metallic impurities on the free silanol activity of commercial thin-layer chromatography adsorbents demonstrated by retention changes of basic/amphoteric compounds such as peptides
  28. Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors
  29. Recent Advances and Applications of Molecular Docking to G Protein-Coupled Receptors
  30. Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry
  31. Synthesis and Pharmacological Evaluation of Novel 1-(1,4-Alkylaryldisubstituted-4,5-dihydro-1H-imidazo)-3-substituted Urea Derivatives
  32. Influence of carboxylic ion-pairing reagents on retention of peptides in thin-layer chromatography systems with C18 silica-based adsorbents
  33. Inversion of type of separation system in planar chromatography of peptides, using C18 silica-based adsorbents
  34. Interplay between Two Allosteric Sites and Their Influence on Agonist Binding in Human μ Opioid Receptor
  35. The xanthophyll cycle pigments, violaxanthin and zeaxanthin, modulate molecular organization of the photosynthetic antenna complex LHCII
  36. Computational methods for studying G protein-coupled receptors (GPCRs)
  37. Fragmental Method KowWIN as the Powerful Tool for Prediction of Chromatographic Behavior of Novel Bioactive Urea Derivatives
  38. Activation and Allosteric Modulation of Human μ Opioid Receptor in Molecular Dynamics
  39. Synthesis, Structural Studies and Molecular Modelling of a Novel Imidazoline Derivative with Antifungal Activity
  40. Structural investigations of a series of 1,6-aryl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-ones with potential antinociceptive activity
  41. Synthesis, antiviral activity and structure–activity relationship of 1-(1-aryl-4,5-dihydro-1H-imidazoline)-3-chlorosulfonylureas and products of their cyclization
  42. Discovery of nitroaryl urea derivatives with antiproliferative properties
  43. The Pseudo-Michael Reaction of 2-Hydrazinylidene-1-Arylimidazolidines with Diethyl Ethoxymethylenemalonate
  44. Synthesis and antiviral activity of 1-(1,3-disubstitutedimidazolidyn-2-ylidene)-3-ethoxycarbonylmethylurea derivatives
  45. Synthesis, Central Nervous System Activity and Structure-Activity Relationships of Novel 1-(1-Alkyl-4-aryl-4,5-dihydro-1H-imidazo)-3-substituted Urea Derivatives
  46. Synthesis, central nervous system activity and structure–activity relationship of N-substituted derivatives of 1-arylimidazolidyn-2-ylideneurea and products of their cyclization
  47. Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of α3β4 nicotinic acetylcholine receptor
  48. Microwave-assisted preparation, structural characterization, lipophilicity, and anti-cancer assay of some hydroxycoumarin derivatives
  49. Modeling the Active Conformation of Human µ Opioid Receptor
  50. Synthesis and molecular docking of novel non-competitive antagonists of GluK2 receptor
  51. Synthesis, Pharmacological Activity and Molecular Modeling of 1-Aryl-7- hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones and their 6-Substituted Derivatives
  52. Synthesis, Experimental and Computational Spectroscopic Studies, and Formation Thermodynamics of Diethyl [[2-(1-Aryl-4,5-dihydro-1H-imidazol- 2-yl)hydrazinyl]methylene]propanedioates
  53. Synthesis, central nervous system activity, and structure–activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones
  54. Structural Studies on N-(1-naphthyl)-3-amino-5-oxo-4-phenyl-1Hpyrazole- 1-carboxamide with Antibacterial Activity
  55. Isothermal titration calorimetry in membrane protein research
  56. Structural studies, homology modeling and molecular docking of novel non-competitive antagonists of GluK1/GluK2 receptors
  57. Synthesis and molecular docking of indole and carbazole derivatives with potential pharmacological activity
  58. Experimental and computational studies on the tautomerism of N-substituted 3-amino-5-oxo-4-phenyl-1H-pyrazolo-1-carboxamides with antibacterial activity
  59. Nuclear Estrogen Receptors Co-activation Mechanisms
  60. The pseudo-Michael reaction of 1-aryl-4,5-dihydro-1H-imidazol-2-amines with ethyl ethoxymethylenecyanoacetate
  61. Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
  62. Structural and Molecular Docking Studies of 4-Benzyl-3-[(1-methylpyrrol- 2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one with Anticancer Activity
  63. Novel Non-Competitive Antagonists of Kainate GluK1/GluK2 Receptors
  64. Usefulness of reversed-phase HPLC enriched with room temperature imidazolium based ionic liquids for lipophilicity determination of the newly synthesized analgesic active urea derivatives
  65. Synthesis of new derivatives of 9-aryl-3-ethoxycarbonylmethyl-2,4,5(9H)-trioxo- 7,8-dihydroimidazo[1,2-a][1,3,5]triazepine
  66. Synthesis of new derivatives of 1-[1-(2-pyridyl)-imidazolidine-2-ylidene]-3-aryl(arylakyl)ureas
  67. Experimental and theoretical investigations on the keto–enol tautomerism of 4-substituted 3-[1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives
  68. 6-(2-Chlorobenzyl)-1-(4-chlorophenyl)-7-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one
  69. Molecular Structure of Ionotropic Glutamate Receptors
  70. Structure-based virtual screening for novel inhibitors of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase
  71. Modeling of Glutamate GluR6 Receptor and Its Interactions with Novel Noncompetitive Antagonists
  72. Synthesis of new derivatives of 9-aryl-2,5(9H)-dioxo-2,3,4,5,7,8-hexahydroimidazo[1,2-a][1,3,5]triazepine
  73. Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D3 Catalog Construction
  74. 1-(3-Chlorophenyl)-3-(1-p-tolylimidazolidin-2-ylidene)urea
  75. Determination of the lipophilicity of selected isoquinoline alkaloids by RP-TLC
  76. Theoretical Studies on the Structure and Symmetry of the Transmembrane Region of Glutamatergic GluR5 Receptor
  77. Crystal Structure of 1-(4-Chlorophenyl)-5(1H)-oxo-2,3-dihydroimidazo[1,2-a]-pyrimidine-6-carbonitrile
  78. Standardized reversed-phase thin-layer chromatographic study of the lipophilicity of five anti-diabetic thiazolidinediones
  79. Electron ionization mass spectra of aryl- and benzyl-substituted 2,3-dihydroimidazo[1,2-a]pyrimidine-5,7(1H,6H)-diones
  80. Use of RP‐HPTLC Systems for the Determination of Lipophilicity of 3,5‐Dioxo‐4‐azatricyclo[5.2.2.02,6]undecanes–5‐HT1A Antagonists
  81. 6-Benzyl-7-hydroxy-1-(2-methoxyphenyl)-2,3-dihydro-1H,7H-imidazo[1,2-a]pyrimidin-5-one
  82. Electron ionization mass spectra of 8-aryl-3,4-dioxo-2H,8H-6,7-dihydroimidazo[2,1-c][1,2,4]triazines. Do they exhibit tautomerism in the gas phase?
  83. Electron ionization mass spectra of 8-aryl-3,4-dioxo-2H,8H-6,7-dihydroimidazo[2,1-c][1,2,4]triazines. Do they exhibit tautomerism in the gas phase?
  84. EMCA and DEEM as Michael Reagents Used in Organic Synthesis
  85. Antinociceptive activity of new imidazolidine carbonyl derivatives.
  86. Synthesis and Structure of 1-(4-chlorophenyl)-2-aminoimidazoline-2
  87. Properties and Application of a Chelating Sorbent Prepared by Modification of LiChroprep-NH 2 with Calcon
  88. Use of binary and ternary mobile phases in reversed-phase high performance liquid chromatographic separation of chiral compounds
  89. Effect of impregnation of silica gel with different zinc salts on the TLC behavior of aromatic hydrocarbons with polar groups
  90. Synthesis and Structure of 1-Methyl-5-(1-naphthyl)-2-aminoimidazoline-2 hydrobromide
  91. The psuedo-michael reaction of 2-aminoimidazolines 2. Part 1. Synthesis and structure assignment of isomeric 5(1H)-Oxo and 7(1H)-Oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylates
  92. DETERMINATION OF CHIRAL DIAMINES BY LC-DAD AND LC WITH POLARIMETRIC DETECTION
  93. Effect of impregnation conditions on the structure and chromatographic behavior of TLC adsorbents modified with Cu(II) and Ni(II) salts
  94. Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine
  95. Non-peptide Opioid Receptor Ligands - Recent Advances. Part I - Agonists
  96. Non-peptide Opioid Receptor Ligands - Recent Advances. Part II - Antagonists
  97. Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine
  98. Comparison of retention of aromatic hydrocarbons with polar groups in binary reversed-phase high-performance liquid chromatography systems
  99. Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine Part 1. Synthesis and pharmacological activity of chain derivatives of 1-aryl-2-iminoimidazolidine containing urea moiety
  100. Electron ionisation induced fragmentation of ethyl 5(1H)-oxo- and 7(1H)-oxo-1-aryl-2,3-dihydroimidazo[1,2-a]-pyrimidine-6-carboxylates: evidence for an unusually regioselective rearrangement of M+? ions
  101. Electron-impact mass spectra of substituted 1-alkyl-2-arylsulphonylamino-1,4,5,6-tetrahydropyrimidines
  102. Electron Impact Mass Spectra of Substituted 1-Aryl-2-arylsulphonylamino-1,4,5,6-tetrahydropyrimidines
  103. Electron impact mass spectra of substituted 1-aryl-2-arylsulphonylamino-δ2-imidzazolines
  104. Synthesis of 1,6-Diaryl-5,7-dioxo(dithio)imidazo[1,2-a][1,3,5]triazines. A Novel Pathway for Imidazo[1,2-a] [1,3,5]triazine Systems Obtained via 1-(Imidazolin-2-yl)urea and Thiourea Derivatives