All Stories

  1. Structural basis for acyl-group discrimination by human Gcn5L2

    Article • Acta Crystallographica Section D Structural Biology, June 2016, International Union of Crystallography

    Dr Cynthia Wolberger

  2. The Substrate Specificity of Sirtuins

    Article • Annual Review of Biochemistry, June 2016, Annual Reviews

    Dr Cynthia Wolberger, Hui Jing, Hening Lin

  3. Uncovering the Role of Sgf73 in Maintaining SAGA Deubiquitinating Module Structure and Activity

    Article • Journal of Molecular Biology, April 2015, Elsevier

    Dr Cynthia Wolberger

  4. Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

    Article • Blood, November 2014, American Society of Hematology

    Dr Cynthia Wolberger

  5. Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2

    Article • Protein Science, October 2014, Wiley

    Dr Cynthia Wolberger

  6. Characterization of the SUMO-Binding Activity of the Myeloproliferative and Mental Retardation (MYM)-Type Zinc Fingers in ZNF261 and ZNF198

    Article • PLoS ONE, August 2014, PLOS

    Dr Cynthia Wolberger

  7. The Bromodomain of Gcn5 Regulates Site Specificity of Lysine Acetylation on Histone H3

    Article • Molecular & Cellular Proteomics, August 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Cynthia Wolberger

  8. New insights into ubiquitin E3 ligase mechanism

    Article • Nature Structural & Molecular Biology, April 2014, Springer Science + Business Media

    Dr Cynthia Wolberger

  9. Mechanisms for regulating deubiquitinating enzymes

    Article • Protein Science, February 2014, Wiley

    Dr Cynthia Wolberger

  10. Corrigendum to “The Structure and Conformation of Lys63-Linked Tetraubiquitin” [J. Mol. Biol. 392 (2009) 1117–1124]

    Article • Journal of Molecular Biology, January 2014, Elsevier

    Dr Cynthia Wolberger

  11. Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase

    Article • Journal of Biological Chemistry, September 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Cynthia Wolberger

  12. A New RING Tossed into an Old HAT

    Article • Structure, September 2013, Elsevier

    Dr Cynthia Wolberger

  13. E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1

    Article • Nature Structural & Molecular Biology, August 2013, Springer Science + Business Media

    Dr Cynthia Wolberger

  14. A New DUB Makes Linear Ubiquitin a Party to Its Own Destruction

    Article • Cell, June 2013, Elsevier

    Dr Cynthia Wolberger

  15. A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants

    Article • Journal of Mass Spectrometry, May 2013, Wiley

    Dr Cynthia Wolberger

  16. Sirtuin on a high-fat diet

    Article • Nature, April 2013, Springer Science + Business Media

    Dr Cynthia Wolberger

  17. A conserved asparagine has a structural role in ubiquitin-conjugating enzymes

    Article • Nature Chemical Biology, January 2013, Springer Science + Business Media

    Dr Cynthia Wolberger

  18. RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

    Article • Science Signaling, December 2012, American Association for the Advancement of Science

    Dr Cynthia Wolberger

  19. A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity

    Article • Structure, August 2012, Elsevier

    Dr Cynthia Wolberger

  20. Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    Dr Cynthia Wolberger

  21. The mechanism of OTUB1-mediated inhibition of ubiquitination

    Article • Nature, February 2012, Springer Science + Business Media

    Dr Cynthia Wolberger

  22. Proteins: histones and chromatin

    Article • Current Opinion in Structural Biology, December 2011, Elsevier

    Dr Cynthia Wolberger

  23. A new chapter in the transcription SAGA

    Article • Current Opinion in Structural Biology, December 2011, Elsevier

    Dr Cynthia Wolberger

  24. A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins

    Article • Analytical Biochemistry, November 2011, Elsevier

    Dr Cynthia Wolberger

  25. Structure of Sir2Tm bound to a propionylated peptide

    Article • Protein Science, December 2010, Wiley

    Dr Cynthia Wolberger, Professor Jorge C Escalante-Semerena

  26. Side chain specificity of ADP-ribosylation by a sirtuin

    Article • FEBS Journal, November 2009, Wiley

    Dr Cynthia Wolberger

  27. The Structure and Conformation of Lys63-Linked Tetraubiquitin

    Article • Journal of Molecular Biology, October 2009, Elsevier

    Dr Cynthia Wolberger

  28. Structure-based Mechanism of ADP-ribosylation by Sirtuins

    Article • Journal of Biological Chemistry, September 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Cynthia Wolberger

  29. Highly Cooperative Recruitment of Ets-1 and Release of Autoinhibition by Pax5

    Article • Journal of Molecular Biology, September 2009, Elsevier

    Dr Cynthia Wolberger

  30. Evidence for Bidentate Substrate Binding as the Basis for the K48 Linkage Specificity of Otubain 1

    Article • Journal of Molecular Biology, March 2009, Elsevier

    Dr Cynthia Wolberger

  31. Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism

    Article • Journal of Biological Chemistry, October 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Cynthia Wolberger

  32. Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction

    Article • Structure, September 2008, Elsevier

    Dr Cynthia Wolberger

  33. Structural and Functional Studies of the Rap1 C-Terminus Reveal Novel Separation-of-Function Mutants

    Article • Journal of Molecular Biology, July 2008, Elsevier

    Dr Cynthia Wolberger

  34. Identification of a New Nicotinamide Binding Site in a Sirtuin: A Reassessment

    Article • Molecular Cell, December 2007, Elsevier

    Dr Cynthia Wolberger

  35. Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

    Article • Cell Metabolism, November 2007, Elsevier

    Dr Cynthia Wolberger

  36. A conserved catalytic residue in the ubiquitin-conjugating enzyme family

    Article • The EMBO Journal, September 2007, Springer Science + Business Media

    Dr Cynthia Wolberger

  37. N-Lysine Propionylation Controls the Activity of Propionyl-CoA Synthetase

    Article • Journal of Biological Chemistry, August 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Cynthia Wolberger, Professor Jorge C Escalante-Semerena

  38. The crystal structure of the tumor suppressor protein pp32 (Anp32a): Structural insights into Anp32 family of proteins

    Article • Protein Science, July 2007, Wiley

    Dr Cynthia Wolberger

  39. Crystal Structure and Solution NMR Studies of Lys48-linked Tetraubiquitin at Neutral pH

    Article • Journal of Molecular Biology, March 2007, Elsevier

    Dr Cynthia Wolberger

  40. Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

    Article • Nature Structural & Molecular Biology, September 2006, Springer Science + Business Media

    Dr Cynthia Wolberger

  41. SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Article • Cell, September 2006, Elsevier

    Dr Cynthia Wolberger

  42. Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide

    Article • Structure, August 2006, Elsevier

    Dr Cynthia Wolberger

  43. Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme

    Article • Nature Structural & Molecular Biology, June 2006, Springer Science + Business Media

    Dr Cynthia Wolberger

  44. The Biochemistry of Sirtuins

    Article • Annual Review of Biochemistry, June 2006, Annual Reviews

    Dr Cynthia Wolberger

  45. The Structural Basis of Sirtuin Substrate Affinity,

    Article • Biochemistry, May 2006, American Chemical Society (ACS)

    Dr Cynthia Wolberger

  46. How does the histone code work?

    Article • Biochemistry and Cell Biology, August 2005, Canadian Science Publishing

    Dr Cynthia Wolberger

  47. Getting a grip on O-acetyl-ADP-ribose

    Article • Nature Structural & Molecular Biology, July 2005, Springer Science + Business Media

    Dr Cynthia Wolberger

  48. Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD+ Cosubstrate Specificity of a Sir2 Enzyme

    Article • Molecular Cell, March 2005, Elsevier

    Dr Cynthia Wolberger

  49. A conserved catalytic residue in the ubiquitin-conjugating enzyme family

    Article • The EMBO Journal, December 2004, Springer Science + Business Media

    Dr Cynthia Wolberger

  50. Regulated nucleosome mobility and the histone code

    Article • Nature Structural & Molecular Biology, November 2004, Springer Science + Business Media

    Dr Cynthia Wolberger

  51. Arm–domain interactions can provide high binding cooperativity

    Article • Protein Science, October 2004, Wiley

    Dr Cynthia Wolberger

  52. Structural Basis for the Mechanism and Regulation of Sir2 Enzymes

    Article • Molecular Cell, March 2004, Elsevier

    Dr Cynthia Wolberger

  53. Insights into nonspecific binding of homeodomains from a structure of MATα2 bound to DNA

    Article • Proteins Structure Function and Bioinformatics, April 2003, Wiley

    Dr Cynthia Wolberger

  54. A core nucleosome surface crucial for transcriptional silencing

    Article • Nature Genetics, September 2002, Springer Science + Business Media

    Dr Cynthia Wolberger

  55. Structure of a Sir2 Enzyme Bound to an Acetylated p53 Peptide

    Article • Molecular Cell, September 2002, Elsevier

    Dr Cynthia Wolberger

  56. Structural and Thermodynamic Characterization of the DNA Binding Properties of a Triple Alanine Mutant of MATα2

    Article • Structure, July 2002, Elsevier

    Dr Cynthia Wolberger

  57. Protein–nucleic acid interactions

    Article • Current Opinion in Structural Biology, February 2002, Elsevier

    Dr Cynthia Wolberger

  58. SIR2 Family of NAD+-Dependent Protein Deacetylases

    Article • January 2002, Elsevier

    Dr Cynthia Wolberger

  59. Structural Studies of Ets-1/Pax5 Complex Formation on DNA

    Article • Molecular Cell, December 2001, Elsevier

    Dr Cynthia Wolberger

  60. Recognition of Specific DNA Sequences

    Article • Molecular Cell, November 2001, Elsevier

    Dr Cynthia Wolberger

  61. A standard reference frame for the description of nucleic acid base-pair geometry

    Article • Journal of Molecular Biology, October 2001, Elsevier

    Dr Cynthia Wolberger

  62. Molecular Insights into Polyubiquitin Chain Assembly

    Article • Cell, June 2001, Elsevier

    Dr Cynthia Wolberger

  63. Crystallization of Protein– DNA Complexes

    Article • April 2001, Wiley

    Dr Cynthia Wolberger

  64. Characterization of the Oligomeric States of Wild Type and Mutant AraC

    Article • Biochemistry, August 2000, American Chemical Society (ACS)

    Dr Cynthia Wolberger

  65. A phylogenetically conserved NAD + -dependent protein deacetylase activity in the Sir2 protein family

    Article • Proceedings of the National Academy of Sciences, June 2000, Proceedings of the National Academy of Sciences

    Dr Cynthia Wolberger, Professor Jorge C Escalante-Semerena

  66. NMR studies of the pbx1 TALE homeodomain protein free in solution and bound to DNA: proposal for a mechanism of HoxB1-pbx1-DNA complex assembly 1 1Edited by P. E. Wright

    Article • Journal of Molecular Biology, August 1999, Elsevier

    Dr Cynthia Wolberger

  67. MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION

    Article • Annual Review of Biophysics and Biomolecular Structure, June 1999, Annual Reviews

    Dr Cynthia Wolberger

  68. Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA

    Article • Cell, February 1999, Elsevier

    Dr Cynthia Wolberger

  69. Combinatorial transcription factors

    Article • Current Opinion in Genetics & Development, October 1998, Elsevier

    Dr Cynthia Wolberger

  70. The 1.6 Å crystal structure of the AraC sugar-binding and dimerization domain complexed with d-fucose

    Article • Journal of Molecular Biology, October 1997, Elsevier

    Dr Cynthia Wolberger

  71. Homeodomain interactions

    Article • Current Opinion in Structural Biology, February 1996, Elsevier

    Dr Cynthia Wolberger

  72. Crystal Structure of the MATa1/MATalpha2 Homeodomain Heterodimer Bound to DNA

    Article • Science, October 1995, American Association for the Advancement of Science

    Dr Cynthia Wolberger

  73. Altered DNA Recognition and Bending by Insertions in the alpha2 Tail of the Yeast a1/alpha2 Homeodomai n Heterodimer

    Article • Science, October 1995, American Association for the Advancement of Science

    Dr Cynthia Wolberger

  74. Crystallization and preliminary X‐ray diffraction studies of an a1/α2/DNA ternary complex

    Article • Proteins Structure Function and Bioinformatics, February 1995, Wiley

    Dr Cynthia Wolberger

  75. b/HLH without the zip

    Article • Nature Structural & Molecular Biology, July 1994, Springer Science + Business Media

    Dr Cynthia Wolberger

  76. Transcription factor structure and DNA binding

    Article • Current Opinion in Structural Biology, February 1993, Elsevier

    Dr Cynthia Wolberger

  77. Structure and DNA Binding of the Yeast MAT 2 Homeodomain

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 1993, Cold Spring Harbor Laboratory Press

    Dr Cynthia Wolberger

  78. Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

    Article • Cell, November 1991, Elsevier

    Dr Cynthia Wolberger

  79. Crystallization and preliminary X-ray diffraction studies of a MATα2-DNA complex

    Article • Journal of Molecular Biology, January 1991, Elsevier

    Dr Cynthia Wolberger

  80. Structure of phage 434 cro protein at 2.35 Å resolution

    Article • Journal of Molecular Biology, January 1989, Elsevier

    Dr Cynthia Wolberger

  81. Structure of a phage 434 Cro/DNA complex

    Article • Nature, October 1988, Springer Science + Business Media

    Dr Cynthia Wolberger

  82. Recognition of DNA sequences by the repressor of bacteriophage 434

    Article • Biophysical Chemistry, February 1988, Elsevier

    Dr Cynthia Wolberger, Dr GERALD B KOUDELKA

  83. Crystallization and X-ray diffraction studies of a 434 Cro-DNA complex

    Article • Journal of Molecular Biology, August 1987, Elsevier

    Dr Cynthia Wolberger