All Stories

  1. The lignan (+)-episesamin interferes with TNF-α-induced activation of VSMC via diminished activation of NF-ĸB, ERK1/2 and AKT and decreased activity of gelatinases

    Article • Acta Physiologica, October 2014, Wiley

    Dr Christian Freise, Dr. Uwe Querfeld

  2. K+ -channel inhibition reduces portal perfusion pressure in fibrotic rats and fibrosis associated characteristics of hepatic stellate cells

    Article • Liver International, September 2014, Wiley

    Dr Christian Freise

  3. Inhibition of vascular calcification by block of intermediate conductance calcium-activated potassium channels with TRAM-34

    Article • Pharmacological Research, July 2014, Elsevier

    Dr Christian Freise, Dr. Uwe Querfeld

  4. The inhibitor of Ca2+-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB

    Article • Investigational New Drugs, October 2012, Springer Science + Business Media

    Dr Christian Freise

  5. The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10promotes enzymatic activity of matrixmetalloproteinase-2in vitro

    Article • European Journal of Microbiology and Immunology, September 2012, Akademiai Kiado

    Dr Christian Freise

  6. The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10ameliorates acute DSS colitis

    Article • European Journal of Microbiology and Immunology, September 2012, Akademiai Kiado

    Dr Christian Freise

  7. Absolute Configuration of Antifi brotic (+)-Episesamin Isolated from Lindera obtusiloba BLUME

    Article • Zeitschrift für Naturforschung C, October 2011, De Gruyter

    Dr Christian Freise

  8. A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines

    Article • BMC Complementary and Alternative Medicine, May 2011, Springer Science + Business Media

    Dr Christian Freise

  9. Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42

    Article • Fibrogenesis & Tissue Repair, January 2011, Springer Science + Business Media

    Dr Christian Freise

  10. An active extract of Lindera obtusiloba inhibits adipogenesis via sustained Wnt signaling and exerts anti-inflammatory effects in the 3T3-L1 preadipocytes

    Article • The Journal of Nutritional Biochemistry, December 2010, Elsevier

    Dr Christian Freise

  11. Episesamin–isoliert aus Lindera obtusiloba–wirkt anti-inflammatorisch und hemmt die autokrine, TGF-β-induzierte Genexpression in hepatischen Sternzellen

    Article • Seminars in Musculoskeletal Radiology, January 2010, Thieme Publishing Group

    Dr Christian Freise

  12. The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity

    Article • Matrix Biology, October 2009, Elsevier

    Dr Christian Freise

  13. Ein wässriger Extrakt von Lindera obtusiloba hemmt die Proliferation und induziert Apoptose in humanen Zelllinien des hepatozellulären Karzinoms

    Article • Seminars in Musculoskeletal Radiology, September 2009, Thieme Publishing Group

    Dr Christian Freise

  14. Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-β-mediated profibrotic gene expression pattern

    Article • The Journal of Nutritional Biochemistry, August 2009, Elsevier

    Dr Christian Freise

  15. 514 TRAM-34 BLOCKS THE INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL (IKCA) IN HUMAN HEPATOMA CELL LINES RESULTING IN REDUCED INVASION AND MIGRATION

    Article • Journal of Hepatology, April 2009, Elsevier

    Dr Christian Freise

  16. Extrakte des stumpflappigen Fieberstrauches Lindera obtusiloba inhibieren die Aktivität von Matrix-Metalloproteinasen und die Expression von Fibrosemarkern in hepatischen Sternzellen

    Article • Seminars in Musculoskeletal Radiology, September 2008, Thieme Publishing Group

    Dr Christian Freise

  17. Das synthetische Kollagenanalogon (GPO)10 stimuliert Proliferation, Migration und die N-Cadherin-Expression in hepatischen Sternzellen via Aktivierung von proMMP-2

    Article • Seminars in Musculoskeletal Radiology, September 2008, Thieme Publishing Group

    Dr Christian Freise

  18. Das Kollagenmimetikum (GPO)10 interagiert mit der Kollagenbindungsdomäne (CBD) der Matrixmetalloproteinase 2 (MMP–2), was zu einer verminderten Bindung an fibrilläres Leberkollagen und zusätzlich zu einem gesteigerten Gelatineumsatz führt

    Article • Seminars in Musculoskeletal Radiology, January 2008, Thieme Publishing Group

    Dr Christian Freise

  19. 472 THE TRIPLEHELICAL PEPTIDE (GPO)10 INTERACTS WITH THE CBD OF MMP-2 RESULTING IN A DIMINISHED BINDING OF MMP-2 TO FIBRILLAR LIVER COLLAGENS AND ENHANCED MATRIX DEGRADATION

    Article • Journal of Hepatology, January 2008, Elsevier

    Dr Christian Freise

  20. Antifibrotische Effekte von Extrakten des japanischen Gewürzbusches Lindera obtusiloba: Unterdrückung der TGF-beta induzierten Kollagen I-Expression und Neutralisation der Peroxid-induzierten ROS-Bildung in hepatischen Sternzellen

    Article • Seminars in Musculoskeletal Radiology, August 2007, Thieme Publishing Group

    Dr Christian Freise

  21. 340 GPO10, a collagen mimetic effectively promotes activation of collagen-bound pro-matrix-metalloproteinase-2 in fibrotic liver tissue

    Article • Journal of Hepatology, April 2006, Elsevier

    Dr Christian Freise

  22. The Elongated First Fibronectin Type III Domain of Collagen XIV Is an Inducer of Quiescence and Differentiation in Fibroblasts and Preadipocytes

    Article • Journal of Biological Chemistry, August 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Christian Freise

  23. ProMMP–2 bindet an Kollagene der Leber und wird durch das Kollagenmimetikum (GPO)10 freigesetzt sowie aktiviert–Bestimmung der Bindungsstärken und Messung der Aktivität des freigesetzten proMMPs mittels Surface-Plasmon-Resonance und Fluorimetrie

    Article • Seminars in Musculoskeletal Radiology, May 2005, Thieme Publishing Group

    Dr Christian Freise