All Stories

  1. Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?

    Article • Expert Opinion on Therapeutic Targets, August 2024, Taylor & Francis

    Dr Chadi G. Abdallah

  2. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor

    Article • NPP—Digital Psychiatry and Neuroscience, June 2024, Springer Science + Business Media

    Dr Chadi G. Abdallah

  3. Ultrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder

    Article • Biological Psychiatry, March 2024, Elsevier

    Dr Chadi G. Abdallah

  4. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge

    Article • Neuropsychopharmacology, January 2024, Springer Science + Business Media

    Dr Chadi G. Abdallah

  5. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge

    Article • Neuropsychopharmacology, October 2023, Springer Science + Business Media

    Dr Chadi G. Abdallah

  6. Neuroimaging-Based Classification of PTSD Using Data-Driven Computational Approaches: A Multisite Big Data Study from the ENIGMA-PGC PTSD Consortium

    Article • NeuroImage, October 2023, Elsevier

    Dr Chadi G. Abdallah

  7. Multimodal Imaging-Based Classification of PTSD Using Data-Driven Computational Approaches: A Multisite Big Data Study from the ENIGMA-PGC PTSD Consortium

    Article • December 2022, Cold Spring Harbor Laboratory Press

    Dr Chadi G. Abdallah, Jean Theberge

  8. A mega-analysis of vertex and gyral cortical thickness differences in adults with and without PTSD

    Article • October 2022, Research Square

    Dr Chadi G. Abdallah

  9. International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators

    Article • Molecular Psychiatry, September 2022, Springer Science + Business Media

    Dr Chadi G. Abdallah

  10. Imaging synaptic density in depression

    Article • Neuropsychopharmacology, June 2022, Springer Science + Business Media

    Dr Chadi G. Abdallah

  11. Correction to: Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial

    Article • Neuropsychopharmacology, May 2022, Springer Science + Business Media

    Dr Chadi G. Abdallah

  12. Investigational drugs for assisting psychotherapy for posttraumatic stress disorder (PTSD): emerging approaches and shifting paradigms in the era of psychedelic medicine

    Article • Expert Opinion on Investigational Drugs, February 2022, Taylor & Francis

    Dr Chadi G. Abdallah

  13. A GIS framework for the application of the Land Degradation Neutrality concept in Mediterranean landscapes

    Article • Geocarto International, February 2022, Taylor & Francis

    Dr Chadi G. Abdallah

  14. Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial

    Article • Neuropsychopharmacology, January 2022, Springer Science + Business Media

    Dr Chadi G. Abdallah

  15. Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder—Updated Systematic Review and Meta-Analysis

    Article • Chronic Stress, January 2022, SAGE Publications

    Dr Chadi G. Abdallah

  16. Novel approaches to estimate prefrontal synaptic strength in vivo in humans: of relevance to depression, schizophrenia, and ketamine

    Article • Neuropsychopharmacology, August 2021, Springer Science + Business Media

    Dr Chadi G. Abdallah

  17. Dose-Related Effects of Ketamine for Antidepressant-Resistant Symptoms of Posttraumatic Stress Disorder in Veterans and Active Duty Military: A Double-blind, Randomized, Placebo-Controlled Multi-Center Clinical Trial

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Dr Chadi G. Abdallah

  18. Brain Functional Connectivity Scans, Acquired Years Before the Pandemic, Predict COVID-19 Infections in Older Adults: Data From 3,662 Participants

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Dr Chadi G. Abdallah

  19. Brain Networks Associated With COVID-19 Risk: Data From 3662 Participants

    Article • Chronic Stress, January 2021, SAGE Publications

    Dr Chadi G. Abdallah

  20. Neurobiology of the Rapid Acting Antidepressant Effects of Ketamine: Impact and Opportunities

    Article • Biological Psychiatry, December 2020, Elsevier

    Dr Chadi G. Abdallah

  21. A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants

    Article • Neuropsychopharmacology, September 2020, Springer Science + Business Media

    Dr Chadi G. Abdallah

  22. A Robust and Reproducible Connectome Fingerprint of Ketamine is Highly Associated with the Connectomic Signature of Antidepressants

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr Chadi G. Abdallah

  23. (2R,6R)-Hydroxynorketamine (HNK) plasma level predicts poor antidepressant response: is this the end of the HNK pipeline?

    Article • Neuropsychopharmacology, April 2020, Springer Science + Business Media

    Dr Chadi G. Abdallah

  24. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

    Article • Neuropsychopharmacology, February 2020, Springer Science + Business Media

    Dr Chadi G. Abdallah

  25. Increased Cortical Thickness in Patients With Major Depressive Disorder Following Antidepressant Treatment

    Article • Chronic Stress, January 2020, SAGE Publications

    Dr Chadi G. Abdallah

  26. Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression

    Article • Chronic Stress, January 2020, SAGE Publications

    Dr Chadi G. Abdallah

  27. Pretreatment Brain Connectome Fingerprint Predicts Treatment Response in Major Depressive Disorder

    Article • Chronic Stress, January 2020, SAGE Publications

    Dr Chadi G. Abdallah

  28. Determining the Hierarchical Architecture of the Human Brain Using Subject-Level Clustering of Functional Networks

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Dr Chadi G. Abdallah

  29. Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial

    Article • Contemporary Clinical Trials, June 2019, Elsevier

    Dr Chadi G. Abdallah

  30. Ketamine: A Paradigm Shift for Depression Research and Treatment

    Article • Neuron, March 2019, Elsevier

    Dr Chadi G. Abdallah

  31. The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder

    Article • The Annual Review of Pharmacology and Toxicology, January 2019, Annual Reviews

    Dr Chadi G. Abdallah

  32. A Review of fMRI Affective Processing Paradigms Used in the Neurobiological Study of Posttraumatic Stress Disorder

    Article • Chronic Stress, January 2019, SAGE Publications

    Dr Chadi G. Abdallah

  33. Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment

    Article • Chronic Stress, January 2019, SAGE Publications

    Dr Chadi G. Abdallah

  34. Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder

    Article • Chronic Stress, January 2019, SAGE Publications

    Dr Chadi G. Abdallah

  35. Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Dr Chadi G. Abdallah

  36. Are There Effective Psychopharmacologic Treatments for PTSD?

    Article • The Journal of Clinical Psychiatry, December 2018, Physicians Postgraduate Press, Inc

    Dr Chadi G. Abdallah

  37. The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

    Article • Pharmacology & Therapeutics, October 2018, Elsevier

    Dr Chadi G. Abdallah

  38. Topology of brain functional connectivity networks in posttraumatic stress disorder

    Article • Data in Brief, October 2018, Elsevier

    Dr Chadi G. Abdallah

  39. Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach

    Article • NeuroImage, August 2018, Elsevier

    Dr Chadi G. Abdallah

  40. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects

    Article • Neuropsychopharmacology, June 2018, Springer Science + Business Media

    Dr Chadi G. Abdallah

  41. Determining the Hierarchical Architecture of the Human Brain Using Subject-Level Clustering of Functional Networks

    Article • June 2018, Cold Spring Harbor Laboratory Press

    Dr Chadi G. Abdallah

  42. Stress Response Modulation Underlying the Psychobiology of Resilience

    Article • Current Psychiatry Reports, March 2018, Springer Science + Business Media

    Dr Chadi G. Abdallah

  43. Neurobiology of the dorsolateral prefrontal cortex in GAD: Aberrant neurometabolic correlation to hippocampus and relationship to anxiety sensitivity and IQ

    Article • Journal of Affective Disorders, March 2018, Elsevier

    Dr Chadi G. Abdallah

  44. Locus Coeruleus Hyperactivity in Posttraumatic Stress Disorder: Answers and Questions

    Article • Biological Psychiatry, February 2018, Elsevier

    Dr Chadi G. Abdallah

  45. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

    Article • Biological Psychiatry, February 2018, Elsevier

    Dr Chadi G. Abdallah

  46. Early Life Stress Associated With Increased Striatal N-Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass, and Behavioral Correlates

    Article • Chronic Stress, January 2018, SAGE Publications

    Dr Chadi G. Abdallah

  47. Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder

    Article • Molecular Neuropsychiatry, January 2018, Karger Publishers

    Dr Chadi G. Abdallah

  48. Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients

    Article • Chronic Stress, January 2018, SAGE Publications

    Dr Chadi G. Abdallah

  49. Neurobiological studies of trauma-related psychopathology: a public health perspective

    Article • European Journal of Psychotraumatology, January 2018, Taylor & Francis

    Dr Chadi G. Abdallah, Teddy Akiki

  50. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder

    Article • Neuropsychopharmacology, September 2017, Springer Science + Business Media

    Dr Chadi G. Abdallah

  51. A Network-Based Neurobiological Model of PTSD: Evidence From Structural and Functional Neuroimaging Studies

    Article • Current Psychiatry Reports, September 2017, Springer Science + Business Media

    Dr Chadi G. Abdallah

  52. Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic

    Article • Current Psychiatry Reports, August 2017, Springer Science + Business Media

    Dr Chadi G. Abdallah

  53. Posttraumatic Stress Disorder: An Integrated Overview of the Neurobiological Rationale for Pharmacology

    Article • Clinical Psychology Science and Practice, July 2017, Wiley

    Dr Chadi G. Abdallah

  54. Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

    Article • Biological Psychiatry Cognitive Neuroscience and Neuroimaging, July 2017, Elsevier

    Dr Chadi G. Abdallah

  55. Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies

    Article • Neuroscience Letters, May 2017, Elsevier

    Dr Chadi G. Abdallah

  56. Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics

    Article • Neuroscience Letters, May 2017, Elsevier

    Dr Chadi G. Abdallah

  57. 67. Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like Symptoms

    Article • Biological Psychiatry, May 2017, Elsevier

    Dr Chadi G. Abdallah

  58. Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression

    Article • Molecular Psychiatry, April 2017, Nature

    Dr Chadi G. Abdallah

  59. What’s the Buzz About Hydroxynorketamine? Is It the History, the Story, the Debate, or the Promise?

    Article • Biological Psychiatry, April 2017, Elsevier

    Dr Chadi G. Abdallah

  60. Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment

    Article • Biological Psychiatry Cognitive Neuroscience and Neuroimaging, April 2017, Elsevier

    Dr Chadi G. Abdallah

  61. Targeting glutamate signalling in depression: progress and prospects

    Article • Nature Reviews Drug Discovery, March 2017, Nature

    Dr Chadi G. Abdallah

  62. The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder

    Article • Neuropsychopharmacology, March 2017, Nature

    Dr Chadi G. Abdallah

  63. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD

    Article • European Neuropsychopharmacology, March 2017, Elsevier

    Dr Chadi G. Abdallah

  64. Anterior hippocampal dysconnectivity in posttraumatic stress disorder: a dimensional and multimodal approach

    Article • Translational Psychiatry, February 2017, Nature

    Dr Chadi G. Abdallah

  65. A New Journal: Addressing the Behavioral and Biological Effects of Chronic Stress

    Article • Chronic Stress, January 2017, SAGE Publications

    Dr Chadi G. Abdallah

  66. Effects of Acute Confinement Stress-induced Hypothalamic-pituitary Adrenal Axis Activation and Concomitant Peripheral and Central Transforming Growth Factor-β1 Measures in Nonhuman Primates

    Article • Chronic Stress, January 2017, SAGE Publications

    Dr Chadi G. Abdallah

  67. Combat Exposure Severity Is Associated With Reduced Cortical Thickness in Combat Veterans: A Preliminary Report

    Article • Chronic Stress, January 2017, SAGE Publications

    Dr Chadi G. Abdallah

  68. The Association of PTSD Symptom Severity With Localized Hippocampus and Amygdala Abnormalities

    Article • Chronic Stress, January 2017, SAGE Publications

    Dr Chadi G. Abdallah

  69. Chronic Pain and Chronic Stress: Two Sides of the Same Coin?

    Article • Chronic Stress, January 2017, SAGE Publications

    Dr Chadi G. Abdallah

  70. Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans

    Article • Chronic Stress, January 2017, SAGE Publications

    Dr Chadi G. Abdallah

  71. Reorganization of brain connectivity in obesity

    Article • Human Brain Mapping, November 2016, Wiley

    Dr Chadi G. Abdallah

  72. PTSD: from neurobiology to pharmacological treatments

    Article • European Journal of Psychotraumatology, November 2016, Taylor & Francis

    Dr Chadi G. Abdallah

  73. Ketamine Treatment and Global Brain Connectivity in Major Depression

    Article • Neuropsychopharmacology, September 2016, Nature

    Dr Chadi G. Abdallah

  74. Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder

    Article • Human Brain Mapping, May 2016, Wiley

    Dr Chadi G. Abdallah

  75. KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS

    Article • Depression and Anxiety, April 2016, Wiley

    Dr Chadi G. Abdallah

  76. Patterns of anterior versus posterior white matter fractional anistotropy concordance in adult nonhuman primates: Effects of early life stress

    Article • Journal of Affective Disorders, March 2016, Elsevier

    Dr Chadi G. Abdallah

  77. Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies

    Article • January 2016, Springer Science + Business Media

    Dr Chadi G. Abdallah

  78. Impact of childhood emotional abuse on neocortical neurometabolites and complex emotional processing in patients with generalized anxiety disorder

    Article • Journal of Affective Disorders, January 2016, Elsevier

    Dr Chadi G. Abdallah

  79. Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology

    Article • Behavioral and Brain Sciences, January 2016, Cambridge University Press

    Dr Chadi G. Abdallah

  80. A history of early life parental loss or separation is associated with successful cognitive-behavioral therapy in major depressive disorder

    Article • Journal of Affective Disorders, November 2015, Elsevier

    Dr Chadi G. Abdallah

  81. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder

    Article • European Neuropsychopharmacology, August 2015, Elsevier

    Dr Chadi G. Abdallah

  82. Neurobiology of Maternal Stress: Role of Social Rank and Central Oxytocin in Hypothalamic–Pituitary Adrenal Axis Modulation

    Article • Frontiers in Psychiatry, July 2015, Frontiers

    Dr Chadi G. Abdallah

  83. Hippocampal volume and the rapid antidepressant effect of ketamine

    Article • Journal of Psychopharmacology, May 2015, SAGE Publications

    Dr Chadi G. Abdallah

  84. Amygdala-Hippocampal Volume and the Phenotypic Heterogeneity of Posttraumatic Stress Disorder

    Article • JAMA Psychiatry, April 2015, American Medical Association (AMA)

    Dr Chadi G. Abdallah

  85. Ketamine as a promising prototype for a new generation of rapid-acting antidepressants

    Article • Annals of the New York Academy of Sciences, February 2015, Wiley

    Dr Chadi G. Abdallah

  86. In Vivo Ketamine-Induced Changes in [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5

    Article • Biological Psychiatry, February 2015, Elsevier

    Dr Chadi G. Abdallah

  87. Rapid Acting Antidepressants

    Article • Annual Review of Medicine, January 2015, Annual Reviews

    Dr Chadi G. Abdallah

  88. Ketamine

    Article • January 2015, Springer Science + Business Media

    Dr Chadi G. Abdallah

  89. Glutamate Metabolism in Major Depressive Disorder

    Article • American Journal of Psychiatry, December 2014, American Psychiatric Association

    Dr Chadi G. Abdallah

  90. Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene

    Article • Frontiers in Behavioral Neuroscience, October 2014, Frontiers

    Dr Chadi G. Abdallah

  91. Morphometric hemispheric asymmetry of orbitofrontal cortex in women with borderline personality disorder: A multi-parameter approach

    Article • Psychiatry Research Neuroimaging, August 2014, Elsevier

    Dr Chadi G. Abdallah

  92. A Neurobiological Hypothesis of Treatment-Resistant Depression – Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy

    Article • Frontiers in Behavioral Neuroscience, May 2014, Frontiers

    Dr Chadi G. Abdallah

  93. Ketamine

    Article • January 2014, Springer Science + Business Media

    Dr Chadi G. Abdallah

  94. Reduced hippocampal N-acetyl-aspartate (NAA) as a biomarker for overweight

    Article • NeuroImage Clinical, January 2014, Elsevier

    Dr Chadi G. Abdallah

  95. Decreased Occipital Cortical Glutamate Levels in Response to Successful Cognitive-Behavioral Therapy and Pharmacotherapy for Major Depressive Disorder

    Article • Psychotherapy and Psychosomatics, January 2014, Karger Publishers

    Dr Chadi G. Abdallah

  96. Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress

    Article • Neuroscience Letters, June 2013, Elsevier

    Dr Chadi G. Abdallah

  97. A pilot study of hippocampal volume and N-acetylaspartate (NAA) as response biomarkers in riluzole-treated patients with GAD

    Article • European Neuropsychopharmacology, April 2013, Elsevier

    Dr Chadi G. Abdallah

  98. Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patients

    Article • Psychiatry Research, December 2012, Elsevier

    Dr Chadi G. Abdallah

  99. Riluzole effect on occipital cortex: A structural and spectroscopy pilot study

    Article • Neuroscience Letters, November 2012, Elsevier

    Dr Chadi G. Abdallah

  100. Rapid Antidepressant Effect of Ketamine in the Electroconvulsive Therapy Setting

    Article • Journal of Ect, September 2012, Wolters Kluwer Health

    Dr Chadi G. Abdallah

  101. Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys

    Article • Physiology & Behavior, July 2011, Elsevier

    Dr Chadi G. Abdallah

  102. Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates

    Article • Psychiatry Research Neuroimaging, April 2011, Elsevier

    Dr Chadi G. Abdallah

  103. Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study

    Article • Psychoneuroendocrinology, February 2011, Elsevier

    Dr Chadi G. Abdallah

  104. Early-life stress and neurometabolites of the hippocampus

    Article • Brain Research, October 2010, Elsevier

    Dr Chadi G. Abdallah

  105. The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates

    Article • Neuroscience Letters, August 2010, Elsevier

    Dr Chadi G. Abdallah

  106. Suicide attempts and associated factors in older adults with schizophrenia

    Article • Schizophrenia Research, June 2010, Elsevier

    Dr Chadi G. Abdallah

  107. Diffusion tensor imaging in studying white matter complexity: A gap junction hypothesis

    Article • Neuroscience Letters, May 2010, Elsevier

    Dr Chadi G. Abdallah

  108. Community Integration and Associated Factors Among Older Adults With Schizophrenia

    Article • Psychiatric Services, December 2009, American Psychiatric Association

    Dr Chadi G. Abdallah

  109. Community Integration and Associated Factors Among Older Adults With Schizophrenia

    Article • Psychiatric Services, December 2009, American Psychiatric Association

    Dr Chadi G. Abdallah