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  1. Liver tissue microbiota linked to nonalcoholic fatty liver disease

    Article • Gut, January 2020, BMJ

    Dr Silvia Sookoian, Dr. Carlos Jose Pirola

  2. Obstructive Sleep Apnea Is Associated with Fatty Liver and Abnormal Liver Enzymes: a Meta-analysis

    Article • Obesity Surgery, June 2013, Springer Science + Business Media

    Dr. Carlos Jose Pirola

  3. Systems Biology Elucidates Common Pathogenic Mechanisms between Nonalcoholic and Alcoholic-Fatty Liver Disease

    Article • PLoS ONE, March 2013, PLOS

    Dr. Carlos Jose Pirola

  4. Circulating MicroRNA-122 signature in nonalcoholic fatty liver disease and cardiovascular disease: A new endocrine system in metabolic syndrome

    Article • Hepatology, March 2013, Wiley

    Dr. Carlos Jose Pirola

  5. Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine

    Article • Current Diabetes Reports, January 2013, Springer Science + Business Media

    Dr. Carlos Jose Pirola

  6. Fetal metabolic programming and epigenetic modifications: a systems biology approach

    Article • Pediatric Research, January 2013, Springer Science + Business Media

    Dr. Carlos Jose Pirola

  7. Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A

    Article • The Journal of Nutritional Biochemistry, January 2013, Elsevier

    Dr. Carlos Jose Pirola

  8. Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1α in a rat model

    Article • Clinical Science, September 2012, Portland Press Ltd.

    Dr. Carlos Jose Pirola

  9. Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease

    Article • Hepatology, August 2012, Wiley

    Dr. Carlos Jose Pirola

  10. Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

    Article • Gut, August 2012, BMJ

    Dr. Carlos Jose Pirola

  11. The Genetic Epidemiology of Nonalcoholic Fatty Liver Disease

    Article • Clinics in Liver Disease, August 2012, Elsevier

    Dr. Carlos Jose Pirola

  12. DNA methylation and hepatic insulin resistance and steatosis

    Article • Current Opinion in Clinical Nutrition & Metabolic Care, July 2012, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  13. Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

    Article • World Journal of Gastroenterology, January 2012, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Dr. Carlos Jose Pirola

  14. Genetic determinants of acquired cholestasis: A systems biology approach

    Article • Frontiers in Bioscience, January 2012, Frontiers in Bioscience

    Dr. Carlos Jose Pirola

  15. PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease

    Article • World Journal of Gastroenterology, January 2012, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Dr. Carlos Jose Pirola

  16. Targeting the renin-angiotensin system: Potential beneficial effects of the angiotensin II receptor blockers in patients with nonalcoholic steatohepatitis

    Article • Hepatology, December 2011, Wiley

    Dr. Carlos Jose Pirola

  17. Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease

    Article • Atherosclerosis, October 2011, Elsevier

    Dr. Carlos Jose Pirola

  18. Mitochondrial DNA copy number is modulated by genetic variation in the signal transducer and activator of transcription 3 (STAT3)

    Article • Metabolism, August 2011, Elsevier

    Dr. Carlos Jose Pirola

  19. Cyclooxygenase inhibition Up-regulates liver carnitine palmitoyltransferase 1A expression and improves fatty liver

    Article • Hepatology, May 2011, Wiley

    Dr. Carlos Jose Pirola

  20. Reply:

    Article • Hepatology, May 2011, Wiley

    Dr. Carlos Jose Pirola

  21. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

    Article • Hepatology, May 2011, Wiley

    Dr. Carlos Jose Pirola

  22. Odor perception between heterosexual partners: Its association with depression, anxiety, and genetic variation in odorant receptor OR7D4

    Article • Biological Psychology, March 2011, Elsevier

    Dr. Carlos Jose Pirola

  23. Cardiac Thyrotropin-Releasing Hormone Mediates Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

    Article • Hypertension, January 2011, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  24. Loci From a Genome-Wide Analysis of Bilirubin Levels Are Associated With Gallstone Risk and Composition

    Article • Gastroenterology, December 2010, Elsevier

    Dr. Carlos Jose Pirola

  25. Metabolic Syndrome: From the Genetics to the Pathophysiology

    Article • Current Hypertension Reports, October 2010, Springer Science + Business Media

    Dr. Carlos Jose Pirola

  26. Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter

    Article • Hepatology, October 2010, Wiley

    Dr. Carlos Jose Pirola

  27. High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia

    Article • Journal of Cellular and Molecular Medicine, July 2010, Wiley

    Dr. Carlos Jose Pirola

  28. GENE-GENE INTERACTION BETWEEN SEROTONIN TRANSPORTER (SLC6A4) ANDCLOCKMODULATES THE RISK OF METABOLIC SYNDROME IN ROTATING SHIFTWORKERS

    Article • Chronobiology International, July 2010, Taylor & Francis

    Dr. Carlos Jose Pirola

  29. Increased levels of resistin in rotating shift workers: A potential mediator of cardiovascular risk associated with circadian misalignment

    Article • Atherosclerosis, June 2010, Elsevier

    Dr. Carlos Jose Pirola

  30. Letter by Landa et al Regarding Article, “Protein Tyrosine Phosphatase 1B, a Major Regulator of Leptin-Mediated Control of Cardiovascular Function”

    Article • Circulation, June 2010, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  31. Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents

    Article • Molecular Genetics and Metabolism, May 2010, Elsevier

    Dr. Carlos Jose Pirola

  32. Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease

    Article • Atherosclerosis, April 2010, Elsevier

    Dr. Carlos Jose Pirola

  33. The influence of common gene variants of the xenobiotic receptor(PXR)in genetic susceptibility to intrahepatic cholestasis of pregnancy

    Article • Alimentary Pharmacology & Therapeutics, March 2010, Wiley

    Dr. Carlos Jose Pirola

  34. Role of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertension

    Article • Journal of Hypertension, February 2010, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  35. Influence of hepatocyte nuclear factor 4α (HNF4α) gene variants on the risk of type 2 diabetes: A meta-analysis in 49,577 individuals

    Article • Molecular Genetics and Metabolism, January 2010, Elsevier

    Dr. Carlos Jose Pirola

  36. The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease

    Article • Pharmacogenetics and Genomics, January 2010, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  37. The impact of maternal high-fat feeding on liver and abdominal fat accumulation in adult offspring under a long-term high-fat diet

    Article • Hepatology, December 2009, Wiley

    Dr. Carlos Jose Pirola

  38. Shift work and subclinical atherosclerosis: Recommendations for fatty liver disease detection

    Article • Atherosclerosis, December 2009, Elsevier

    Dr. Carlos Jose Pirola

  39. Genetic Variation in the FAAH Gene and Metabolic Syndrome–related Phenotypes

    Article • Obesity, November 2009, Wiley

    Dr. Carlos Jose Pirola

  40. Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease

    Article • The Journal of Nutritional Biochemistry, October 2009, Elsevier

    Dr. Carlos Jose Pirola

  41. Losartan reduces liver expression of plasminogen activator inhibitor-1 (PAI-1) in a high fat-induced rat nonalcoholic fatty liver disease model

    Article • Atherosclerosis, September 2009, Elsevier

    Dr. Carlos Jose Pirola

  42. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

    Article • Journal of Lipid Research, May 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Carlos Jose Pirola

  43. A diagnostic model to differentiate simple steatosis from nonalcoholic steatohepatitis based on the likelihood ratio form of Bayes theorem

    Article • Clinical Biochemistry, May 2009, Elsevier

    Dr. Carlos Jose Pirola

  44. Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes

    Article • Genetics in Medicine, May 2009, Springer Science + Business Media

    Dr. Carlos Jose Pirola

  45. Maternal Pregestational BMI Is Associated With Methylation of thePPARGC1APromoter in Newborns

    Article • Obesity, May 2009, Wiley

    Dr. Carlos Jose Pirola

  46. Angiotensin-(1-7) through AT2receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway

    Article • Journal of Neurochemistry, April 2009, Wiley

    Dr. Carlos Jose Pirola

  47. Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease

    Article • Cytokine, October 2008, Elsevier

    Dr. Carlos Jose Pirola

  48. Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

    Article • Journal of Hepatology, October 2008, Elsevier

    Dr. Carlos Jose Pirola

  49. A Decreased Mitochondrial DNA Content Is Related to Insulin Resistance in Adolescents

    Article • Obesity, July 2008, Wiley

    Dr. Carlos Jose Pirola

  50. Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes

    Article • Heart, July 2008, BMJ

    Dr. Carlos Jose Pirola

  51. Study of Genetic Variation in theSTAT3on Obesity and Insulin Resistance in Male Adults

    Article • Obesity, July 2008, Wiley

    Dr. Carlos Jose Pirola

  52. Should Nonalcoholic Fatty Liver Disease Be Included in the Definition of Metabolic Syndrome? A Cross-Sectional Comparison With Adult Treatment Panel III Criteria in Nonobese Nondiabetic Subjects: Response to Musso et al.

    Article • Diabetes Care, April 2008, American Diabetes Association

    Dr. Carlos Jose Pirola

  53. Contribution of the Functional 5-HTTLPR Variant of the SLC6A4 Gene to Obesity Risk in Male Adults

    Article • Obesity, February 2008, Wiley

    Dr. Carlos Jose Pirola

  54. Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy

    Article • Journal of Hepatology, January 2008, Elsevier

    Dr. Carlos Jose Pirola

  55. Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy

    Article • World Journal of Gastroenterology, January 2008, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Dr. Carlos Jose Pirola

  56. Association between diencephalic thyroliberin and arterial blood pressure in agouti-yellow and ob/ob mice may be mediated by leptin

    Article • Metabolism, October 2007, Elsevier

    Dr. Carlos Jose Pirola

  57. Review: Genetics of the cardiometabolic syndrome: new insights and therapeutic implications

    Article • Therapeutic Advances in Cardiovascular Disease, October 2007, SAGE Publications

    Dr. Carlos Jose Pirola

  58. Knocking down the diencephalic thyrotropin-releasing hormone precursor gene normalizes obesity-induced hypertension in the rat

    Article • AJP Endocrinology and Metabolism, May 2007, American Physiological Society

    Dr. Carlos Jose Pirola

  59. Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation

    Article • Journal of Internal Medicine, March 2007, Wiley

    Dr. Carlos Jose Pirola

  60. Short Allele of Serotonin Transporter Gene Promoter Is a Risk Factor for Obesity in Adolescents*

    Article • Obesity, February 2007, Wiley

    Dr. Carlos Jose Pirola

  61. Association of the C−344T aldosterone synthase gene variant with essential hypertension: a meta-analysis

    Article • Journal of Hypertension, January 2007, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  62. SiRNA-mediated silencing of the diencephalic thyrotropin-releasing hormone precursor gene decreases the arterial blood pressure in the obese agouti mice

    Article • Frontiers in Bioscience, January 2007, Frontiers in Bioscience

    Dr. Carlos Jose Pirola

  63. Mitochondrial DNA Depletion in Small- and Large-for-Gestational-Age Newborns*

    Article • Obesity, December 2006, Wiley

    Dr. Carlos Jose Pirola

  64. Integrative study of hypothalamus–pituitary–thyroid–immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway

    Article • Journal of Endocrinology, April 2006, Bioscientifica

    Dr. Carlos Jose Pirola

  65. Peroxisome proliferator-activated receptor gamma and its coactivator-1 alpha may be associated with features of the metabolic syndrome in adolescents

    Article • Journal of Molecular Endocrinology, October 2005, Bioscientifica

    Dr. Carlos Jose Pirola

  66. The G-308A Promoter Variant of the Tumor Necrosis Factor-α Gene Is Associated With Hypertension in Adolescents Harboring the Metabolic Syndrome

    Article • American Journal of Hypertension, October 2005, Oxford University Press (OUP)

    Dr. Carlos Jose Pirola

  67. Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation

    Article • Blood, June 2005, American Society of Hematology

    Dr. Carlos Jose Pirola

  68. Thyrotropin-releasing hormone in cardiovascular pathophysiology

    Article • Regulatory Peptides, June 2005, Elsevier

    Dr. Carlos Jose Pirola

  69. Parathyroid Hormone-Related Protein Overexpression Decreases Blood Pressure in Spontaneously Hypertensive Rats

    Article • Clinical and Experimental Hypertension, May 2005, Taylor & Francis

    Dr. Carlos Jose Pirola

  70. A1166C Angiotensin II Type 1 Receptor Gene Polymorphism May Predict Hemodynamic Response to Losartan in Patients with Cirrhosis and Portal Hypertension

    Article • The American Journal of Gastroenterology, March 2005, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  71. PDGF-A, PDGF-B, TGF?, and bFGF mRNA levels in patients with essential thrombocythemia treated with anagrelide

    Article • American Journal of Hematology, January 2005, Wiley

    Dr. Carlos Jose Pirola

  72. Normal platelets possess the soluble form of IL-6 receptor

    Article • Cytokine, November 2004, Elsevier

    Dr. Carlos Jose Pirola

  73. Clinical Features of the Metabolic Syndrome in Adolescents: Minor Role of the Trp64Arg β3-Adrenergic Receptor Gene Variant

    Article • Pediatric Research, May 2004, Springer Science + Business Media

    Dr. Carlos Jose Pirola

  74. Hyperhomocysteinemia but not MTHFR genotype is associated with young-onset essential hypertension

    Article • Journal of Human Hypertension, May 2003, Springer Science + Business Media

    Dr. Carlos Jose Pirola

  75. Renin–Angiotensin–Aldosterone System Loci and Multilocus Interactions in Young‐Onset Essential Hypertension

    Article • Clinical and Experimental Hypertension, January 2003, Taylor & Francis

    Dr. Carlos Jose Pirola

  76. Thyrotropin-Releasing Hormone Decreases Leptin and Mediates the Leptin-Induced Pressor Effect

    Article • Hypertension, February 2002, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  77. Parathyroid hormone-related protein expression in vascular smooth muscle of spontaneously hypertensive rats

    Article • Journal of Hypertension, October 1998, Wolters Kluwer Health

    Dr. Carlos Jose Pirola

  78. Angiotensin II enhances long-term memory in the crab Chasmagnathus

    Article • Brain Research Bulletin, January 1996, Elsevier

    Dr. Carlos Jose Pirola

  79. Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor and its messenger ribonucleic acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells: cell-specific regulation by angiotensin- II and PTHrP

    Article • Endocrinology, September 1994, Endocrine Society

    Dr. Carlos Jose Pirola

  80. Mechanical stimuli induce vascular parathyroid hormone-related protein gene expression in vivo and in vitro

    Article • Endocrinology, May 1994, Endocrine Society

    Dr. Carlos Jose Pirola

  81. Effects of N-terminal, midregion, and C-terminal parathyroid hormone- related peptides on adenosine 3',5'-monophosphate and cytoplasmic free calcium in rat aortic smooth muscle cells and UMR-106 osteoblast-like cells

    Article • Endocrinology, December 1993, Endocrine Society

    Dr. Carlos Jose Pirola

  82. Brain amines in glucocorticoid-induced hypertension in the rat

    Article • Neuroscience Letters, February 1992, Elsevier

    Dr. Carlos Jose Pirola

  83. The cholinergic system participates in thyrotropin-releasing hormone (TRH) regulation

    Article • Neuroscience Letters, February 1992, Elsevier

    Dr. Carlos Jose Pirola

  84. Cholinergic hyperactivity in the lateral septal area of spontaneously hypertensive rats: Depressor effect of hemicholinium-3 and pirenzepine

    Article • Neuropharmacology, April 1991, Elsevier

    Dr. Carlos Jose Pirola

  85. Increase in muscarinic receptors in rat intestine by Thyrotropin Releasing Hormone (TRH)

    Article • Life Sciences, April 1984, Elsevier

    Dr. Carlos Jose Pirola

  86. Thyrotropin-releasing hormone increases the number of muscarinic receptors in the lateral septal area of the rat brain

    Article • Brain Research, August 1983, Elsevier

    Dr. Carlos Jose Pirola

  87. Serotonergic and noradrenergic mechanisms involved in the cardiovascular effects of angiotensin II injected into the anterior hypothalamic preoptic region of rats

    Article • Neuropharmacology, January 1981, Elsevier

    Dr. Carlos Jose Pirola