All Stories

  1. Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

    Article • Medicinal Chemistry, September 2020, Bentham Science Publishers

    Dr Solange L Castro, Dr Carlos AM Fraga

  2. NF-κB-IKKβ pathway as a target for drug development: realities, challenges and perspectives

    Article • Current Drug Targets, February 2018, Bentham Science Publishers

    Dr Carlos AM Fraga

  3. Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2018, Taylor & Francis

    Professor Fabio Furlan Ferreira, Dr Carlos AM Fraga

  4. Adenosine A2A  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

    Article • Drug Design Development and Therapy, March 2017, Dove Medical Press

    JAQUELINE DA SILVA, Professor Eliezer J Barreiro , Dr Carlos AM Fraga, Leanne Groban

  5. HDAC6 as target for drug discovery

    Article • Mini-Reviews in Medicinal Chemistry, August 2016, Bentham Science Publishers

    Dr Carlos AM Fraga, sreekanth thota

  6. A target for treatment of cocaine addiction

    Article • Medicinal Chemistry, July 2016, Bentham Science Publishers

    Dr Carlos AM Fraga

  7. LASSBio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model

    Article • Behavioural Pharmacology, June 2016, Wolters Kluwer Health

    Dr Carlos AM Fraga

  8. Filtering promiscuous compounds in early drug discovery: is it a good idea?

    Article • Drug Discovery Today, June 2016, Elsevier

    Dr Carlos AM Fraga

  9. Novel Agonist of Adenosine Receptor Induces Relaxation of Corpus Cavernosum in Guinea Pigs: An In Vitro and In Vivo Study

    Article • Urology, May 2015, Elsevier

    Dr Carlos AM Fraga

  10. Synthesis and Biological Evaluation of Pyrazolo[3,4-b]pyridin-4-ones as a New Class of Topoisomerase II Inhibitors

    Article • Medicinal Chemistry, April 2015, Bentham Science Publishers

    Dr Carlos AM Fraga

  11. Message-Address Concept in Medicinal Chemistry

    Article • Revista Virtual de Química, January 2015, Sociedade Brasileira de Quimica (SBQ)

    Dr Carlos AM Fraga

  12. N-acylhydrazone group in drug candidates

    Article • Expert Opinion on Therapeutic Patents, September 2014, Informa Healthcare

    Dr Carlos AM Fraga

  13. Novel Potent Imidazo[1,2-a]pyridine-N-Glycinyl-Hydrazone Inhibitors of TNF-α Production: In Vitro and In Vivo Studies

    Article • PLoS ONE, March 2014, PLOS

    Dr Carlos AM Fraga

  14. PM391 Improvement Of Vascular And Cardiac Remodeling By Benzoylhydrazone Derivative In Rats With Monocrotaline-Induced Pulmonary Hypertension

    Article • Global Heart, March 2014, Elsevier

    Dr Carlos AM Fraga

  15. PM390 Recovery Of Vascular And Ventricular Dysfunction By A New N-Acylhydrazone Derivative In Experimental Pulmonary Hypertension

    Article • Global Heart, March 2014, Elsevier

    Dr Carlos AM Fraga

  16. Crystal structures of 1-hydroxylimidazole and imidazole 1-oxide derivatives

    Article • Zeitschrift für Kristallographie - Crystalline Materials, January 2014, De Gruyter

    Dr Carlos AM Fraga

  17. N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle

    Article • Life Sciences, January 2014, Elsevier

    Dr Carlos AM Fraga

  18. Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives

    Article • Molecules, September 2013, MDPI AG

    Dr Carlos AM Fraga

  19. The Role of Natural Products on the Discovery of New Drug Candidates for Neurogenerative Disorders

    Article • September 2013, Bentham Science Publishers

    Dr Carlos AM Fraga

  20. Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579

    Article • European Journal of Medicinal Chemistry, August 2013, Elsevier

    Dr Carlos AM Fraga

  21. Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats

    Article • Clinical and Experimental Pharmacology and Physiology, June 2013, Wiley

    Dr Carlos AM Fraga

  22. Article Synthesis and Trypanocidal Activity of Novel 2,4,5-Triaryl-N-Hydroxylimidazole Derivatives

    Article • Molecules, March 2013, MDPI AG

    Dr Carlos AM Fraga

  23. Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet

    Article • Journal of Pharmacological Sciences, January 2013, Japanese Pharmacological Society

    Dr Carlos AM Fraga

  24. New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia

    Article • Behavioural Brain Research, January 2013, Elsevier

    Dr Carlos AM Fraga

  25. Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production

    Article • PLoS ONE, October 2012, PLOS

    Dr Carlos AM Fraga

  26. Vasodilator and antihypertensive effects of a novelN-acylhydrazone derivative mediated by the inhibition of L-type Ca2+channels

    Article • Fundamental and Clinical Pharmacology, September 2012, Wiley

    Dr Carlos AM Fraga

  27. Phenylpiperazine derivatives: a patent review (2006 – present)

    Article • Expert Opinion on Therapeutic Patents, September 2012, Informa Healthcare

    Dr Carlos AM Fraga

  28. Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor

    Article • European Journal of Medicinal Chemistry, September 2012, Elsevier

    Dr Carlos AM Fraga

  29. New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis

    Article • International Journal of Hypertension, January 2012, Hindawi Publishing Corporation

    Dr Carlos AM Fraga

  30. Molecular docking and molecular dynamic studies of semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors

    Article • Journal of the Brazilian Chemical Society, January 2012, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  31. Novel Therapeutic Strategies for Chagas` Disease

    Article • December 2011, IntechOpen

    Dr Carlos AM Fraga

  32. MAOS and Medicinal Chemistry: Some Important Examples from the Last Years

    Article • Molecules, November 2011, MDPI AG

    Dr Carlos AM Fraga

  33. Molecular Modeling Studies ofYersinia pestisDihydrofolate Reductase

    Article • Journal of Biomolecular Structure and Dynamics, October 2011, Taylor & Francis

    Teodorico C. Ramalho, Dr Carlos AM Fraga

  34. The Methylation Effect in Medicinal Chemistry

    Article • Chemical Reviews, September 2011, American Chemical Society (ACS)

    Professor Eliezer J Barreiro , Dr Carlos AM Fraga

  35. Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3,4-methylenedioxybenzoyl-2-thienylhydrazone

    Article • Journal of Molecular Modeling, September 2011, Springer Science + Business Media

    Dr Carolina Horta Andrade, Dr Carlos AM Fraga

  36. Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LC–MS/MS: Application for a pharmacokinetic study

    Article • Journal of Pharmaceutical and Biomedical Analysis, July 2011, Elsevier

    Dr Carlos AM Fraga

  37. Novel furfurylideneN-acylhydrazones derived from natural safrole: discovery of LASSBio-1215, a new potent antiplatelet prototype

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, May 2011, Taylor & Francis

    Dr Carlos AM Fraga

  38. Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β

    Article • European Journal of Medicinal Chemistry, April 2011, Elsevier

    Dr Carlos AM Fraga

  39. The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinsons Disease

    Article • CNS & Neurological Disorders - Drug Targets, March 2011, Bentham Science Publishers

    Dr Carlos AM Fraga

  40. The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease

    Article • CNS & Neurological Disorders - Drug Targets, March 2011, Bentham Science Publishers

    Dr Carlos AM Fraga

  41. CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes

    Article • European Journal of Medicinal Chemistry, January 2011, Elsevier

    Dr Carlos AM Fraga

  42. Discovery of Dual Chemotherapy Drug Candidates Designed by Molecular Hybridization

    Article • Current Enzyme Inhibition, December 2010, Bentham Science Publishers

    Dr Carlos AM Fraga

  43. Cardiovascular effects induced byN-(4'-dihydro)-piperoylthiomorpholine in normotensive rats

    Article • Journal of Pharmacy and Pharmacology, October 2010, Wiley

    Dr Carlos AM Fraga

  44. Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives

    Article • Letters in Drug Design & Discovery, October 2010, Bentham Science Publishers

    Dr Carlos AM Fraga

  45. LASSBio-294, A Compound With Inotropic and Lusitropic Activity, Decreases Cardiac Remodeling and Improves Ca2+ Influx Into Sarcoplasmic Reticulum After Myocardial Infarction

    Article • American Journal of Hypertension, July 2010, Oxford University Press (OUP)

    Dr Carlos AM Fraga

  46. Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition

    Article • European Journal of Pharmacology, July 2010, Elsevier

    Dr Carlos AM Fraga

  47. Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581

    Article • Bioorganic & Medicinal Chemistry Letters, May 2010, Elsevier

    Dr Carolina Horta Andrade, Dr Carlos AM Fraga

  48. Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors

    Article • Bioorganic & Medicinal Chemistry, March 2010, Elsevier

    Dr Carlos AM Fraga

  49. Microwave-assisted synthesis and structure–activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, January 2010, Elsevier

    Dr Carlos AM Fraga

  50. Characterization of the conformational ensemble from bioactive N-acylhydrazone derivatives

    Article • Journal of Molecular Graphics and Modelling, January 2010, Elsevier

    Dr Carlos AM Fraga

  51. Discovery of novel heteroarylazoleN-phenylpiperazine prototypes candidates to atypic antipsychotic drugs

    Article • Revista Virtual de Química, January 2010, Sociedade Brasileira de Quimica (SBQ)

    Dr Carlos AM Fraga

  52. Structural insights into IKKβ inhibition by natural products staurosporine and quercetin

    Article • Bioorganic & Medicinal Chemistry Letters, December 2009, Elsevier

    Dr Carlos AM Fraga

  53. Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors

    Article • Pharmacology Biochemistry and Behavior, November 2009, Elsevier

    Dr Carlos AM Fraga

  54. Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives

    Article • European Journal of Medicinal Chemistry, October 2009, Elsevier

    Dr Carlos AM Fraga

  55. Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)

    Article • Bioorganic & Medicinal Chemistry Letters, September 2009, Elsevier

    Dr Carlos AM Fraga

  56. From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’

    Article • Mini-Reviews in Medicinal Chemistry, June 2009, Bentham Science Publishers

    Dr Carlos AM Fraga

  57. Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors

    Article • European Journal of Medicinal Chemistry, June 2009, Elsevier

    Dr Carlos AM Fraga

  58. Drug hybridization strategies: before or after lead identification?

    Article • Expert Opinion on Drug Discovery, May 2009, Informa Healthcare

    Dr Carlos AM Fraga

  59. Synthesis, pharmacological evaluation and docking studies of new sulindac analogues

    Article • European Journal of Medicinal Chemistry, May 2009, Elsevier

    Dr Carlos AM Fraga

  60. Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: Orally effective anti-inflammatory drug candidates

    Article • Bioorganic & Medicinal Chemistry, February 2009, Elsevier

    Prof. Javier Alcides Ellena, Dr Carlos AM Fraga

  61. Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes

    Article • Bioorganic & Medicinal Chemistry, January 2009, Elsevier

    Dr Carlos AM Fraga

  62. Extração e purificação de fármacos anti-inflamatórios não esteroidais ciclo-oxigenase-2 seletivos

    Article • Química Nova, January 2009, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  63. NSAIDs revisited: Putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARγ)

    Article • European Journal of Medicinal Chemistry, September 2008, Elsevier

    Dr Carlos AM Fraga

  64. Pharmacokinetic evaluation of LASSBio-579: anN-phenylpiperazine antipsychotic prototype

    Article • Journal of Pharmacy and Pharmacology, June 2008, Wiley

    Dr Carlos AM Fraga

  65. Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581

    Article • Pharmacology Biochemistry and Behavior, March 2008, Elsevier

    Dr Carlos AM Fraga

  66. Improved Solvent‐Free Dakin Oxidation Protocol

    Article • Synthetic Communications, February 2008, Taylor & Francis

    Dr Carlos AM Fraga

  67. CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (−)-spectaline

    Article • European Journal of Pharmacology, February 2008, Elsevier

    Dr Carlos AM Fraga

  68. Synthesis and anti-platelet activity of novel arylsulfonate–acylhydrazone derivatives, designed as antithrombotic candidates

    Article • European Journal of Medicinal Chemistry, February 2008, Elsevier

    Dr Carlos AM Fraga

  69. New Insights for Multifactorial Disease Therapy: The Challenge of the Symbiotic Drugs

    Article • Current Drug Therapy, January 2008, Bentham Science Publishers

    Professor Eliezer J Barreiro , Dr Carlos AM Fraga

  70. Antinociceptive Profile of 2,3,6-Trisubstituted Piperidine Alkaloids: 3-O-Acetyl-spectaline and Semi-synthetic Derivatives of (−)-Spectaline

    Article • Chemical and Pharmaceutical Bulletin, January 2008, Pharmaceutical Society of Japan

    Dr Carlos AM Fraga

  71. Studies toward the structural optimization of new brazilizone-related trypanocidal 1,3,4-thiadiazole-2-arylhydrazone derivatives

    Article • Bioorganic & Medicinal Chemistry, January 2008, Elsevier

    Dr Carlos AM Fraga

  72. Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates

    Article • Mini-Reviews in Medicinal Chemistry, November 2007, Bentham Science Publishers

    Dr Carlos AM Fraga

  73. The Molecular Basis of COX-2 Versus COX-1 Selectivity of Lumiracoxib by Molecular Docking Studies

    Article • Letters in Drug Design & Discovery, September 2007, Bentham Science Publishers

    Dr Carlos AM Fraga

  74. Molecular Hybridization: A Useful Tool in the Design of New Drug Prototypes

    Article • Current Medicinal Chemistry, July 2007, Bentham Science Publishers

    Dr Carlos AM Fraga

  75. Atropoisomerismo: o efeito da quiralidade axial em substâncias bioativas

    Article • Química Nova, February 2007, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  76. High performance liquid chromatography method for quantification of the N-phenylpiperazine derivative LASSBio-579 in rat plasma

    Article • Química Nova, January 2007, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  77. Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties

    Article • Bioorganic & Medicinal Chemistry, December 2006, Elsevier

    Dr Carlos AM Fraga

  78. Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phthalimide-containing TNFα modulators

    Article • Bioorganic & Medicinal Chemistry, October 2006, Elsevier

    Dr Carlos AM Fraga

  79. Microbial reduction of α-acetyl-γ-butyrolactone

    Article • Tetrahedron Asymmetry, March 2006, Elsevier

    Dr Carlos AM Fraga, Yraima Cordeiro, Professor Francisco Radler de Aquino Neto

  80. Thalidomide and Analogs as Anti-Inflammatory and Immunomodulator Drug Candidates

    Article • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, February 2006, Bentham Science Publishers

    Dr Carlos AM Fraga

  81. Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives with in vivo hypnotic and analgesic profile

    Article • Bioorganic & Medicinal Chemistry, February 2006, Elsevier

    Dr Carlos AM Fraga

  82. Medicinal Chemistry of N-Acylhydrazones: New Lead-Compounds of Analgesic, Antiinflammatory and Antithrombotic Drugs

    Article • Current Medicinal Chemistry, January 2006, Bentham Science Publishers

    Dr Carlos AM Fraga

  83. A questão da inovação em fármacos no Brasil: proposta de criação do programa nacional de fármacos (Pronfar)

    Article • Química Nova, December 2005, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  84. A proposed molecular basis for the selective resveratrol inhibition of the PGHS-1 peroxidase activity

    Article • Bioorganic & Medicinal Chemistry, November 2005, Elsevier

    Dr Carlos AM Fraga

  85. New Anti-Alzheimer Drugs from Biodiversity: The Role of the Natural Acetylcholinesterase Inhibitors

    Article • Mini-Reviews in Medicinal Chemistry, October 2005, Bentham Science Publishers

    Dr Carlos AM Fraga

  86. Pharmacokinetics and tissue distribution of a new heterocyclic N-phenylpiperazine derivative (LASSBio-581) in rats

    Article • European Journal of Pharmaceutical Sciences, October 2005, Elsevier

    Dr Carlos AM Fraga

  87. The molecular basis for coxib inhibition of p38α MAP kinase

    Article • Bioorganic & Medicinal Chemistry Letters, August 2005, Elsevier

    Dr Carlos AM Fraga

  88. New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids

    Article • Bioorganic & Medicinal Chemistry, July 2005, Elsevier

    Dr Carlos AM Fraga

  89. Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues

    Article • Bioorganic & Medicinal Chemistry, May 2005, Elsevier

    Dr Carlos AM Fraga

  90. Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats

    Article • European Journal of Pharmacology, March 2005, Elsevier

    Dr Carlos AM Fraga

  91. Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide

    Article • Bioorganic & Medicinal Chemistry Letters, February 2005, Elsevier

    Dr Carlos AM Fraga

  92. Agentes dopaminérgicos e o tratamento da disfunção erétil

    Article • Química Nova, December 2004, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  93. New optimized piperamide analogues with potent in vivo hypotensive properties

    Article • European Journal of Pharmaceutical Sciences, December 2004, Elsevier

    Dr Carlos AM Fraga

  94. Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues

    Article • Bioorganic & Medicinal Chemistry Letters, December 2004, Elsevier

    Dr Carlos AM Fraga

  95. Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer

    Article • Química Nova, August 2004, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  96. New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives

    Article • Bioorganic & Medicinal Chemistry, June 2004, Elsevier

    Dr Carlos AM Fraga

  97. Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal

    Article • Química Nova, June 2004, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  98. Cysteinyl Leukotriene Receptor Antagonists and Thromboxane Synthase Inhibitors: New Targets to Treat Asthma

    Article • Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents, March 2004, Bentham Science Publishers

    Dr Carlos AM Fraga

  99. Studies on diastereoselective reduction of cyclic β-ketoesters with boron hydrides. Part 4: The reductive profile of functionalized cyclohexanone derivatives

    Article • Tetrahedron, March 2004, Elsevier

    Dr Carlos AM Fraga, Professor Francisco Radler de Aquino Neto

  100. Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands

    Article • Bioorganic & Medicinal Chemistry, November 2003, Elsevier

    Dr Carlos AM Fraga

  101. Novas estratégias terapêuticas para o tratamento da depressão: uma visão da química medicinal

    Article • Química Nova, May 2003, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  102. Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives

    Article • Bioorganic & Medicinal Chemistry, May 2003, Elsevier

    Dr Carlos AM Fraga

  103. Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3- d ]pyridine and Pyrazolo[3,4- b ][1,8]naphthyridine Isosteres:  A New Class of Potent and Selective Acetylcholinesterase Inhibitors

    Article • Journal of Medicinal Chemistry, March 2003, American Chemical Society (ACS)

    Dr Carlos AM Fraga

  104. Chiral separation of γ-butyrolactone derivatives by gas chromatography on 2,3-di-O-methyl-6-O-tert.-butyldimethylsilyl-β-cyclodextrin

    Article • Journal of Chromatography A, January 2003, Elsevier

    Dr Carlos AM Fraga, Professor Francisco Radler de Aquino Neto

  105. Synthesis and pharmacological evaluation of novel antinociceptive N-substituted-phenylimidazolyl-4-acylhydrazone derivatives

    Article • Il Farmaco, December 2002, Elsevier

    Dr Carlos AM Fraga

  106. Synthesis and biological evaluation of new imidazo[1,2-a]pyridine derivatives designed as mefloquine analogues

    Article • Il Farmaco, September 2002, Elsevier

    Dr Carlos AM Fraga

  107. Agentes antiasmáticos modernos: antagonistas de receptores de leucotrienos cisteínicos

    Article • Química Nova, September 2002, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  108. Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues

    Article • Bioorganic & Medicinal Chemistry, September 2002, Elsevier

    Dr Carlos AM Fraga

  109. Novel phthalimide derivatives, designed as leukotriene D4 receptor antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, June 2002, Elsevier

    Dr Carlos AM Fraga

  110. Highly diastereoselective mercury-mediated synthesis of functionalized 2-azabicyclo[3.3.0]octane derivatives

    Article • Tetrahedron Letters, February 2002, Elsevier

    Dr Carlos AM Fraga

  111. A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos

    Article • Química Nova, February 2002, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  112. Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: a new class of anti-inflammatory and anti-platelet agents

    Article • Bioorganic & Medicinal Chemistry Letters, January 2002, Elsevier

    Dr Carlos AM Fraga

  113. STUDIES ON THE DIASTEREO- SELECTIVE REDUCTION OF 2-ACETYL-2-ALKYL- γ-BUTYROLACTONES WITH BORON HYDRIDES1*

    Article • Synthetic Communications, January 2002, Taylor & Francis

    Dr Carlos AM Fraga, Professor Francisco Radler de Aquino Neto

  114. O renascimento de um fármaco: talidomida

    Article • Química Nova, October 2001, FapUNIFESP (SciELO)

    Professor Eliezer J Barreiro , Dr Carlos AM Fraga

  115. Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative

    Article • Journal of the Brazilian Chemical Society, June 2001, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  116. SYNTHESIS OF NATURAL AMIDE ALKALOID PIPERDARDINE AND A NEW BIOACTIVE ANALOGUE†

    Article • Synthetic Communications, January 2001, Taylor & Francis

    Dr Carlos AM Fraga

  117. Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists

    Article • European Journal of Pharmaceutical Sciences, October 2000, Elsevier

    Dr Carlos AM Fraga

  118. O-Alkylation of Bioactive Phthalimide Derivatives Under Microwave Irradiation in Dry Media

    Article • Synthetic Communications, September 2000, Taylor & Francis

    Dr Carlos AM Fraga

  119. Design and Synthesis of Novel Potent Antinociceptive Agents: Methyl-imidazolyl N-Acylhydrazone Derivatives

    Article • Bioorganic & Medicinal Chemistry, September 2000, Elsevier

    Dr Carlos AM Fraga

  120. Synthesis of Functionalized γ-Spirolactone and 2-Oxabicyclo[3.3.0]octane Derivatives from Nucleophilic Oxirane Ring Opening

    Article • Tetrahedron, July 2000, Elsevier

    Dr Carlos AM Fraga

  121. Chiral Gas Chromatographic Separation of 2-Oxabicyclo[3.3.0]octane Derivatives and Their Synthetic Precursors

    Article • Analytical Chemistry, July 2000, American Chemical Society (ACS)

    Dr Carlos AM Fraga, Professor Francisco Radler de Aquino Neto

  122. Studies on antiplatelet agents from natural safrole

    Article • Pharmaceutica Acta Helvetiae, December 1999, Elsevier

    Dr Carlos AM Fraga

  123. Synthesis and analgesic profile of novel N-containing heterocycle derivatives: arylidene 3-phenyl-1,2,4-oxadiazole-5-carbohydrazide

    Article • Il Farmaco, November 1999, Elsevier

    Dr Carlos AM Fraga

  124. New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole

    Article • Journal of the Brazilian Chemical Society, October 1999, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  125. A utilização do safrol, principal componente químico do óleo de sassafráz, na síntese de substâncias bioativas na cascata do ácido araquidônico: antiinflamatórios, analgésicos e anti-trombóticos

    Article • Química Nova, September 1999, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  126. Proposal of a new PAF pharmacophoric map by the AM1 method

    Article • European Journal of Pharmaceutical Sciences, August 1999, Elsevier

    Dr Carlos AM Fraga

  127. Synthesis and antiplatelet evaluation of novel aryl-sulfonamide derivatives, from natural safrole

    Article • Pharmaceutica Acta Helvetiae, June 1999, Elsevier

    Dr Carlos AM Fraga

  128. Synthesis of Piperamides and New Analogues from Natural Safrole

    Article • Synthetic Communications, January 1999, Taylor & Francis

    Dr Carlos AM Fraga

  129. SYNTHESIS OF NEW ISOSTERIC HETEROTRICYCLIC DERIVATIVES: PYRAZOLO[3,4-b]THIENO[3,2-e]PYRIDINE, PYRAZOLO[3,4-b]PYRROLO[3,2-e]PYRIDINE AND FURO[2,3-b]PYRAZOLO[4,3-e]PYRIDINE

    Article • Heterocyclic Communications, January 1999, De Gruyter

    Dr Carlos AM Fraga

  130. Inibidores seletivos de prostaglandina endoperóxido sintase-2 (PGHS-2): nova estratégia para o tratamento da inflamação

    Article • Química Nova, November 1998, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  131. Synthesis and pharmacological evaluation of a new class of bicyclic phospholipids, designed as platelet activating factor antagonists

    Article • Il Farmaco, May 1998, Elsevier

    Dr Carlos AM Fraga

  132. Synthesis of New Benzylic Ethers of Oximes Derived from 1-Phenyl-pyrazole Compounds

    Article • Synthetic Communications, April 1998, Taylor & Francis

    Dr Carlos AM Fraga

  133. Synthesis of new 1,2-Benzothiazin-3-one Derivatives Designed as Dual Cyclooxygenase-2 and 5-Lipooxygenase Inhibitors

    Article • Journal of the Brazilian Chemical Society, April 1998, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  134. Synthesis and antinociceptive properties of new structurally planned imidazo[1,2-a]pyridine 3-acylarylhydrazone derivatives

    Article • European Journal of Medicinal Chemistry, March 1998, Elsevier

    Dr Carlos AM Fraga

  135. Studies on Diastereoselective Synthesis of 3-Vinyl-5-carbomethoxy-2-oxabicyclo[3.3.0]octane Derivatives Employing Palladium(II) Oxidative Cyclization

    Article • Heterocycles, January 1998, Japan Institute of Heterocyclic Chemistry

    Dr Carlos AM Fraga

  136. Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole

    Article • Bioorganic & Medicinal Chemistry Letters, January 1998, Elsevier

    Dr Carlos AM Fraga

  137. Reduction of 2-Alkyl-2-carbomethoxy-cyclopentanone Derivatives with Sodium Borohydride. II. The Elucidation of the Diastereoselective Controla

    Article • Synthetic Communications, September 1997, Taylor & Francis

    Dr Carlos AM Fraga

  138. Síntese de β-cetoésteres cíclicos: novo procedimento para ciclizações de Dieckmann empregando ALCL3 e trietilamina

    Article • Química Nova, August 1997, FapUNIFESP (SciELO)

    Dr Carlos AM Fraga

  139. Improvement of enantioselective syntheses and chiral high resolution gas chromatographic analyses of (+)‐2‐allyl‐2‐carboethoxy‐cyclopentanol

    Article • Chirality, January 1997, Wiley

    Dr Carlos AM Fraga

  140. Improvement of enantioselective syntheses and chiral high resolution gas chromatographic analyses of (+)-2-allyl-2-carboethoxy-cyclopentanol

    Article • Chirality, January 1997, Wiley

    Dr Carlos AM Fraga, Professor Francisco Radler de Aquino Neto

  141. Synthesis of condensed tricyclic pyrazolo[3,4-b]thieno[2,3-d]pyridine and related isostere derivatives

    Article • Journal of Heterocyclic Chemistry, March 1996, Wiley

    Dr Carlos AM Fraga

  142. Enantiofacial selective reduction of 2-allyl-2-carboethoxy-cyclopentanone mediated by baker's yeast

    Article • Chirality, January 1996, Wiley

    Professor Eliezer J Barreiro , Dr Carlos AM Fraga

  143. Design and Synthesis of a New 4-Oxa-8.OMEGA.-11-deoxy-5,6-dihydroprostacyclin Analogue.

    Article • Chemical and Pharmaceutical Bulletin, January 1996, Pharmaceutical Society of Japan

    Dr Carlos AM Fraga

  144. Molecular modeling on platelet-activating factor (PAF) and new proposed PAF antagonists

    Article • International Journal of Quantum Chemistry, January 1996, Wiley

    Dr Carlos AM Fraga

  145. Synthesis and Anti-Platelet Evaluation of New Tricyclic PAF Antagonists, Designed as Structurally Related to Hetrazepine Class - Web 2086

    Article • Journal of the Brazilian Chemical Society, January 1996, Sociedade Brasileira de Quimica (SBQ)

    Dr Carlos AM Fraga

  146. Semiempirical calculations on the mechanism of stereoselective NaBH4 reduction of 2-methoxycarbonyl-2-allyl-cyclopentanone

    Article • Journal of Molecular Structure THEOCHEM, September 1995, Elsevier

    Dr Carlos AM Fraga

  147. Safrole-derived Antiinflammatory Oxicams

    Article • Journal of Heterocyclic Chemistry, October 1992, Wiley

    Dr Carlos AM Fraga