All Stories

  1. An Overview of Circulating Cell-Free Nucleic Acids in Diagnosis and Prognosis of Triple-Negative Breast Cancer

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Bruna Scaggiante

  2. High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy

    Article • International Journal of Molecular Sciences, April 2022, MDPI AG

    Bruna Scaggiante

  3. An Overview of siRNA Delivery Strategies for Urological Cancers

    Article • Pharmaceutics, March 2022, MDPI AG

    Bruna Scaggiante

  4. Xenograft Zebrafish Models for the Development of Novel Anti-Hepatocellular Carcinoma Molecules

    Article • Pharmaceuticals, August 2021, MDPI AG

    Bruna Scaggiante

  5. Effects of eEF1A1 targeting by aptamer/siRNA in chronic lymphocytic leukaemia cells

    Article • International Journal of Pharmaceutics, January 2020, Elsevier

    Bruna Scaggiante

  6. Correction: Elevated levels of eEF1A2 protein expression in triple negative breast cancer relate with poor prognosis

    Article • PLoS ONE, December 2019, PLOS

    Bruna Scaggiante

  7. A rapid and specific method to simultaneously quantify eukaryotic elongation factor 1A1 and A2 protein levels in cancer cells

    Article • Journal of Pharmaceutical and Biomedical Analysis, November 2019, Elsevier

    Professor Sabina Passamonti, Bruna Scaggiante

  8. Cell-free DNA analysis in healthy individuals by next-generation sequencing: a proof of concept and technical validation study

    Article • Cell Death and Disease, July 2019, Springer Science + Business Media

    Bruna Scaggiante

  9. Elevated levels of eEF1A2 protein expression in triple negative breast cancer relate with poor prognosis

    Article • PLoS ONE, June 2019, PLOS

    Bruna Scaggiante

  10. Current status of PI3K-mTOR inhibition in hormone-receptor positive, HER2-negative breast cancer

    Article • World Journal of Clinical Oncology, December 2018, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Bruna Scaggiante

  11. Cell-free DNA integrity for the monitoring of breast cancer: Future perspectives?

    Article • World Journal of Clinical Oncology, April 2018, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Bruna Scaggiante

  12. Dissecting the role of the elongation factor 1A isoforms in hepatocellular carcinoma cells by liposome-mediated delivery of siRNAs

    Article • International Journal of Pharmaceutics, June 2017, Elsevier

    Bruna Scaggiante

  13. Breastfeeding: a reproductive factor able to reduce the risk of luminal B breast cancer in premenopausal White women

    Article • European Journal of Cancer Prevention, May 2017, Wolters Kluwer Health

    Bruna Scaggiante

  14. Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

    Article • Anti-Cancer Agents in Medicinal Chemistry, October 2016, Bentham Science Publishers

    Professor Sabina Passamonti, Bruna Scaggiante

  15. Aptamer targeting of the elongation factor 1A impairs hepatocarcinoma cells viability and potentiates bortezomib and idarubicin effects

    Article • International Journal of Pharmaceutics, June 2016, Elsevier

    Bruna Scaggiante

  16. Novel Lipid and Polymeric Materials as Delivery Systems for Nucleic Acid Based Drugs

    Article • Current Drug Metabolism, October 2015, Bentham Science Publishers

    Bruna Scaggiante

  17. EEF1A1 (eukaryotic translation elongation factor 1 alpha 1)

    Article • Atlas of Genetics and Cytogenetics in Oncology and Haematology, March 2015, INIST-CNRS

    Bruna Scaggiante

  18. Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials

    Article • World Journal of Gastroenterology, January 2014, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Bruna Scaggiante

  19. Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines

    Article • World Journal of Gastroenterology, January 2014, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Bruna Scaggiante

  20. Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases

    Article • Current Medicinal Chemistry, August 2013, Bentham Science Publishers

    Gaetano Lamberti, Bruna Scaggiante

  21. Aptamers as Targeting Delivery Devices or Anti-cancer Drugs for Fighting Tumors

    Article • Current Drug Metabolism, June 2013, Bentham Science Publishers

    Bruna Scaggiante

  22. The more basic isoform of eEF1A relates to tumour cell phenotype and is modulated by hyper-proliferative/differentiating stimuli in normal lymphocytes and CCRF-CEM T-lymphoblasts

    Article • Hematological Oncology, August 2012, Wiley

    Bruna Scaggiante

  23. Effects of E2F1–cyclin E1–E2 circuit down regulation in hepatocellular carcinoma cells

    Article • Digestive and Liver Disease, December 2011, Elsevier

    Bruna Scaggiante

  24. Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression

    Article • British Journal of Cancer, November 2011, Springer Science + Business Media

    Bruna Scaggiante

  25. EEF1A1 (eukaryotic translation elongation factor 1 alpha 1)

    Article • Atlas of Genetics and Cytogenetics in Oncology and Haematology, November 2011, INIST-CNRS

    Bruna Scaggiante

  26. Two-dimensional enzyme diffusion in laterally confined DNA monolayers

    Article • Nature Communications, May 2011, Springer Science + Business Media

    Bruna Scaggiante

  27. Improving siRNA Bio-Distribution and Minimizing Side Effects

    Article • Current Drug Metabolism, January 2011, Bentham Science Publishers

    Bruna Scaggiante

  28. Current Strategies to Improve the Efficacy and the Delivery of Nucleic Acid Based Drugs

    Article • Current Signal Transduction Therapy, May 2010, Bentham Science Publishers

    Bruna Scaggiante

  29. Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels

    Article • Biochimie, March 2009, Elsevier

    Bruna Scaggiante

  30. Prostate Tumor-Inducing Gene-1 Analysis in Human Prostate Cancer Cells and Tissue in Relation toMycoplasmaInfection

    Article • Cancer Investigation, January 2008, Taylor & Francis

    Bruna Scaggiante

  31. Overexpression of the elongation factor 1A1 relates to muscle proteolysis and proapoptotic p66(ShcA) gene transcription in hypercatabolic trauma patients

    Article • Metabolism, December 2007, Elsevier

    Bruna Scaggiante

  32. The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade

    Article • Biochimie, December 2007, Elsevier

    Bruna Scaggiante

  33. Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines

    Article • FEBS Journal, April 2006, Wiley

    Bruna Scaggiante

  34. Anxiety stress and nociceptive responses in mice

    Article • Life Sciences, February 2006, Elsevier

    Bruna Scaggiante

  35. Aptameric GT oligomers need to be complexed to ethoxylated polyethylenimine as pre-paired duplexes to efficiently exert their cytotoxic activity in human lymphoblastic cancer cells

    Article • Biochimie, August 2005, Elsevier

    Bruna Scaggiante

  36. Diurnal changes of tonic nociceptive responses in mice: evidence for a proalgesic role of melatonin

    Article • Pain, July 2004, Wolters Kluwer Health

    Bruna Scaggiante

  37. Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers

    Article • European Journal of Biochemistry, August 2003, Wiley

    Bruna Scaggiante

  38. Increase in Therapeutic Index of Doxorubicin and Vinblastine by Aptameric Oligonucleotide in Human T Lymphoblastic Drug-Sensitive and Multidrug-Resistant Cells

    Article • Antisense and Nucleic Acid Drug Development, August 2002, Mary Ann Liebert Inc

    Bruna Scaggiante

  39. Alpha-Anomeric Configuration of GT Oligodeoxynucleotide Leads to Loss of the Specific Aptameric and Cytotoxic Properties Retained by the Beta-Anomeric Analog

    Article • Antisense and Nucleic Acid Drug Development, December 2001, Mary Ann Liebert Inc

    Bruna Scaggiante

  40. Effect of phosphorothioate modifications on the ability of GTn oligodeoxynucleotides to specifically recognize single-stranded DNA-binding proteins and to affect human cancer cellular growth

    Article • Biochimie, December 1999, Elsevier

    Bruna Scaggiante

  41. Effect of Oligomer Length and Base Substitutions on the Cytotoxic Activity and Specific Nuclear Protein Recognition of GTn Oligonucleotides in the Human Leukemic CCRF-CEM Cell Line

    Article • Nucleosides and Nucleotides, June 1999, Taylor & Francis

    Bruna Scaggiante

  42. Formation of Triple Helices at Irregular Poly (R·Y) Sites Located in Critical Positions in the HumanBCRPromoter

    Article • Nucleosides and Nucleotides, June 1999, Taylor & Francis

    Bruna Scaggiante

  43. Reduction ofmdrlGene Amplification in Human Multidrug-Resistant LoVo DX Cell Line Is Promoted by Triple Helix-Forming Oligonucleotides

    Article • Antisense and Nucleic Acid Drug Development, June 1999, Mary Ann Liebert Inc

    Bruna Scaggiante

  44. Effect of cations on purine.purine.pyrimidine triple helix formation in mixed-valence salt solutions

    Article • European Journal of Biochemistry, March 1999, Wiley

    Bruna Scaggiante

  45. Human cancer cell lines growth inhibition by GTn oligodeoxyribonucleotides recognizing single-stranded DNA-binding proteins

    Article • European Journal of Biochemistry, March 1998, Wiley

    Bruna Scaggiante

  46. Effect of unmodified triple helix-forming oligodeoxyribonucleotide targeted to human multidrug-resistance genemdr1in MDR cancer cells

    Article • FEBS Letters, October 1994, Wiley

    Bruna Scaggiante

  47. Treatment of sphingomyelinase deficiency by repeated implantations of amniotic epithelial cells

    Article • American Journal of Medical Genetics, November 1992, Wiley

    Bruna Scaggiante

  48. Secretion of lysosomal hydrolases by cultured human amnion epithelial cells

    Article • Experimental Cell Research, July 1991, Elsevier

    Bruna Scaggiante

  49. Repeated Implantations of Human Amniotic Epithelial Cells as a Curative Therapy of Niemann-Pick Disease

    Article • January 1988, Springer Science + Business Media

    Bruna Scaggiante

  50. SUCCESSFUL THERAPY OF NIEMANN-PICK DISEASE BY IMPLANTATION OF HUMAN AMNIOTIC MEMBRANE

    Article • Transplantation, July 1987, Wolters Kluwer Health

    Bruna Scaggiante

  51. Modulation of human neutrophil function by C-reactive protein

    Article • European Journal of Biochemistry, February 1987, Wiley

    Bruna Scaggiante