All Stories

  1. Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA

    Article • PLoS Biology, June 2019, PLOS

    Dr Benoit Gamain

  2. The sickle cell trait affects contact dynamics and endothelial cell activation in Plasmodium falciparum-infected erythrocytes

    Article • Communications Biology, November 2018, Springer Science + Business Media

    Dr Benoit Gamain

  3. Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development

    Article • npj Vaccines, July 2018, Springer Science + Business Media

    Dr Benoit Gamain

  4. Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1–4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies

    Article • Malaria Journal, June 2018, Springer Science + Business Media

    Dr Benoit Gamain

  5. Host factors that modify Plasmodium falciparum adhesion to endothelial receptors

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Dr Benoit Gamain

  6. Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1

    Article • The Journal of Infectious Diseases, June 2017, Oxford University Press (OUP)

    Dr Benoit Gamain

  7. Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria

    Article • Scientific Reports, May 2017, Springer Science + Business Media

    Dr Benoit Gamain

  8. Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria

    Article • Cell Host & Microbe, March 2017, Elsevier

    Dr Benoit Gamain

  9. TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood

    Article • Scientific Reports, September 2016, Springer Science + Business Media

    Dr Benoit Gamain

  10. Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

    Article • Malaria Journal, September 2016, Springer Science + Business Media

    Dr Benoit Gamain

  11. Murine Model for Preclinical Studies of Var2CSA-Mediated Pathology Associated with Malaria in Pregnancy

    Article • Infection and Immunity, April 2016, ASM Journals

    Dr Benoit Gamain, Dr. Claudio Romero Farias Marinho

  12. Erratum to: Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding

    Article • Malaria Journal, January 2016, Springer Science + Business Media

    Dr Benoit Gamain

  13. Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding

    Article • Malaria Journal, December 2015, Springer Science + Business Media

    Dr Benoit Gamain

  14. Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions

    Article • Scientific Reports, October 2015, Springer Science + Business Media

    Dr Benoit Gamain

  15. Parity-Dependent Recognition of DBL1X-3X Suggests an Important Role of the VAR2CSA High-Affinity CSA-Binding Region in the Development of the Humoral Response against Placental Malaria

    Article • Infection and Immunity, March 2015, ASM Journals

    Dr Benoit Gamain

  16. Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum

    Article • March 2015, Protein Data Bank, Rutgers University

    Dr Benoit Gamain

  17. Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

    Article • Scientific Reports, December 2014, Springer Science + Business Media

    Dr Benoit Gamain

  18. High-Throughput Screening Platform Identifies Small Molecules That Prevent Sequestration ofPlasmodium falciparum–Infected Erythrocytes

    Article • The Journal of Infectious Diseases, October 2014, Oxford University Press (OUP)

    Dr Benoit Gamain

  19. Placental Cytokine and Chemokine Profiles Reflect Pregnancy Outcomes in Women Exposed to Plasmodium falciparum Infection

    Article • Infection and Immunity, June 2014, ASM Journals

    Dr Benoit Gamain

  20. Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6∊-FCR3 of thePlasmodium falciparumVAR2CSA protein. Corrigendum

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, October 2013, International Union of Crystallography

    Dr Benoit Gamain

  21. Structural and Immunological Correlations between the Variable Blocks of the VAR2CSA Domain DBL6ε from Two Plasmodium falciparum Parasite Lines

    Article • Journal of Molecular Biology, May 2013, Elsevier

    Dr Benoit Gamain

  22. Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6∊-FCR3 of thePlasmodium falciparumVAR2CSA protein

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2013, International Union of Crystallography

    Dr Benoit Gamain

  23. Expressing Full-Length Functional PfEMP1 Proteins in the HEK293 Expression System

    Article • January 2012, Springer Science + Business Media

    Dr Benoit Gamain

  24. Var2CSA Minimal CSA Binding Region Is Located within the N-Terminal Region

    Article • PLoS ONE, May 2011, PLOS

    Dr Benoit Gamain

  25. Antibodies to a Full-Length VAR2CSA Immunogen Are Broadly Strain-Transcendent but Do Not Cross-Inhibit Different Placental-Type Parasite Isolates

    Article • PLoS ONE, February 2011, PLOS

    Dr Benoit Gamain

  26. Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

    Article • Proceedings of the National Academy of Sciences, March 2010, Proceedings of the National Academy of Sciences

    Dr Benoit Gamain

  27. How does Plasmodium falciparum stick to CSA? Let's see in the crystal

    Article • Nature Structural & Molecular Biology, September 2008, Springer Science + Business Media

    Dr Benoit Gamain

  28. Investigation of host factors possibly enhancing the emergence of the chondroitin sulfate A-binding phenotype in Plasmodium falciparum

    Article • Microbes and Infection, July 2008, Elsevier

    Dr Benoit Gamain

  29. Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites

    Article • Malaria Journal, January 2008, Springer Science + Business Media

    Dr Benoit Gamain

  30. Structural polymorphism and diversifying selection on the pregnancy malaria vaccine candidate VAR2CSA

    Article • Molecular and Biochemical Parasitology, October 2007, Elsevier

    Dr Benoit Gamain

  31. Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype

    Article • PLoS ONE, September 2007, PLOS

    Dr Benoit Gamain

  32. Pregnancy-associated malaria: Parasite binding, natural immunity and vaccine development

    Article • International Journal for Parasitology, March 2007, Elsevier

    Dr Benoit Gamain

  33. Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies

    Article • Microbes and Infection, November 2006, Elsevier

    Dr Benoit Gamain

  34. The human placental derived BeWo cell line: A useful model for selecting Plasmodium falciparum CSA-binding parasites

    Article • Experimental Parasitology, February 2006, Elsevier

    Dr Benoit Gamain

  35. A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A

    Article • EMBO Reports, August 2005, EMBO

    Dr Benoit Gamain

  36. Identification of Multiple Chondroitin Sulfate A (CSA)–Binding Domains in the var2CSA Gene Transcribed in CSA‐Binding Parasites

    Article • The Journal of Infectious Diseases, March 2005, Oxford University Press (OUP)

    Dr Benoit Gamain

  37. Identification of a 67-amino-acid region of the Plasmodium falciparum variant surface antigen that binds chondroitin sulphate A and elicits antibodies reactive with the surface of placental isolates

    Article • Molecular Microbiology, June 2004, Wiley

    Dr Benoit Gamain

  38. Induction of crossreactive antibodies against the Plasmodium falciparum variant protein

    Article • Proceedings of the National Academy of Sciences, October 2003, Proceedings of the National Academy of Sciences

    Dr Benoit Gamain

  39. DNA Immunization with the Cysteine-Rich Interdomain Region 1 of the Plasmodium falciparum Variant Antigen Elicits Limited Cross-Reactive Antibody Responses

    Article • Infection and Immunity, August 2003, ASM Journals

    Dr Benoit Gamain

  40. Molecular basis for the dichotomy in Plasmodium falciparum adhesion to CD36 and chondroitin sulfate A

    Article • Proceedings of the National Academy of Sciences, July 2002, Proceedings of the National Academy of Sciences

    Dr Benoit Gamain

  41. Definition of the minimal domain of CIDR1α of Plasmodium falciparum PfEMP1 for binding CD36

    Article • Molecular and Biochemical Parasitology, April 2002, Elsevier

    Dr Benoit Gamain

  42. Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line

    Article • Proceedings of the National Academy of Sciences, March 2002, Proceedings of the National Academy of Sciences

    Dr Benoit Gamain

  43. Decoding the language of var genes and Plasmodium falciparum sequestration

    Article • Trends in Parasitology, November 2001, Elsevier

    Dr Benoit Gamain

  44. Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36

    Article • Blood, May 2001, American Society of Hematology

    Dr Benoit Gamain

  45. The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes

    Article • Proceedings of the National Academy of Sciences, February 2001, Proceedings of the National Academy of Sciences

    Dr Benoit Gamain

  46. The Putative Glutathione Peroxidase Gene of Plasmodium falciparum Codes for a Thioredoxin Peroxidase

    Article • Journal of Biological Chemistry, November 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Benoit Gamain

  47. Classification of adhesive domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 family

    Article • Molecular and Biochemical Parasitology, October 2000, Elsevier

    Dr Benoit Gamain

  48. Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection

    Article • Proceedings of the National Academy of Sciences, October 1999, Proceedings of the National Academy of Sciences

    Dr Benoit Gamain

  49. Babesia hylomysci and B. divergens : presence of antioxidant enzymes destroying hydrogen peroxide

    Article • Parasitology Research, November 1997, Springer Science + Business Media

    Dr Benoit Gamain

  50. Molecular characterization of the glutathione peroxidase gene of the human malaria parasite Plasmodium falciparum

    Article • Molecular and Biochemical Parasitology, June 1996, Elsevier

    Dr Benoit Gamain

  51. The course of Plasmodium berghei, P. chabaudi and P. yoelii infections in β-thalassaemic mice

    Article • Parasitology, March 1996, Cambridge University Press

    Dr Benoit Gamain

  52. Increase in glutathione peroxidase activity in malaria parasite after selenium supplementation

    Article • Free Radical Biology and Medicine, January 1996, Elsevier

    Dr Benoit Gamain