All Stories

  1. New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and In Vitro Pharmacological Evaluation

    Article • Medicinal Chemistry, May 2020, Bentham Science Publishers

    Professor Beatrice Severino, Dr Ferdinando Fiorino

  2. Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments

    Article • Current Pharmaceutical Design, July 2019, Bentham Science Publishers

    Dr Ferdinando Fiorino, Professor Beatrice Severino

  3. The Role of 5-HT1A Receptor in Cancer as a New Opportunity in Medicinal Chemistry

    Article • Current Medicinal Chemistry, September 2018, Bentham Science Publishers

    Dr Ferdinando Fiorino, Professor Beatrice Severino

  4. Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents

    Article • Anti-Cancer Agents in Medicinal Chemistry, June 2017, Bentham Science Publishers

    Professor Beatrice Severino

  5. Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production

    Article • Scientific Reports, October 2016, Nature

    Professor Beatrice Severino

  6. Quantification of 3α-hydroxytibolone in human plasma by high performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS): Application in a bioequivalence study in healthy postmenopausal volunteers

    Article • Analytical Chemistry Research, June 2016, Elsevier

    Professor Beatrice Severino

  7. 5-HT2 receptor affinity, docking studies and pharmacological evaluation of a series of 1,3-disubstituted thiourea derivatives

    Article • European Journal of Medicinal Chemistry, June 2016, Elsevier

    Professor Beatrice Severino

  8. Level, potential sources of polycyclic aromatic hydrocarbons (PAHs) in particulate matter (PM10) in Naples

    Article • Atmospheric Environment, March 2016, Elsevier

    Professor Beatrice Severino

  9. Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus

    Article • European Journal of Medicinal Chemistry, March 2016, Elsevier

    Professor Beatrice Severino

  10. Identification of a novel selective CSE inhibitor through a combined pharmacological and metabolomic approach

    Article • Nitric Oxide, May 2015, Elsevier

    Professor Beatrice Severino

  11. Synthesis, biological evaluation, and docking studies of PAR2-AP-derived pseudopeptides as inhibitors of kallikrein 5 and 6

    Article • Biological Chemistry, January 2015, De Gruyter

    Professor Beatrice Severino

  12. Synthesis andIn VitroPharmacological Evaluation of Novel 2-Hydroxypropyl-4-arylpiperazine Derivatives as Serotoninergic Ligands

    Article • Archiv der Pharmazie, August 2014, Wiley

    Dr Ferdinando Fiorino, Professor Beatrice Severino

  13. 5-HT 1A Receptor: An Old Target as a New Attractive Tool in Drug Discovery from Central Nervous System to Cancer

    Article • Journal of Medicinal Chemistry, June 2014, American Chemical Society (ACS)

    Professor Beatrice Severino

  14. Identification of a pepducin acting as S1P3 receptor antagonist

    Article • Journal of Peptide Science, September 2013, Wiley

    Professor Beatrice Severino

  15. Kallikrein Protease Activated Receptor (PAR) Axis: An Attractive Target for Drug Development

    Article • Journal of Medicinal Chemistry, August 2012, American Chemical Society (ACS)

    Professor Beatrice Severino

  16. Synthesis of benzamide derivatives and their evaluation as antiprion agents

    Article • Bioorganic & Medicinal Chemistry, August 2012, Elsevier

    Professor Beatrice Severino

  17. New potent 5-HT2A receptor ligands containing an N′-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation

    Article • European Journal of Medicinal Chemistry, January 2012, Elsevier

    Professor Beatrice Severino

  18. ChemInform Abstract: Synthesis by Microwave Irradiation and Binding Properties of Novel 5-HT1A Receptor Ligands.

    Article • ChemInform, May 2010, Wiley

    Professor Beatrice Severino

  19. Thrombin receptors and their antagonists: an update on the patent literature

    Article • Expert Opinion on Therapeutic Patents, May 2010, Informa Healthcare

    Professor Beatrice Severino

  20. New 5-HT1A receptor ligands containing a N′-cyanoisonicotinamidine nucleus: Synthesis and in vitro pharmacological evaluation

    Article • Bioorganic & Medicinal Chemistry Letters, May 2010, Elsevier

    Professor Beatrice Severino

  21. Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands

    Article • European Journal of Medicinal Chemistry, February 2010, Elsevier

    Professor Beatrice Severino

  22. A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats

    Article • Pharmacological Research, May 2009, Elsevier

    Professor Beatrice Severino

  23. Efficient microwave-assisted synthesis of 4-amino-2-benzazepin-3-ones as conformationally restricted dipeptide mimetics

    Article • Tetrahedron, January 2009, Elsevier

    Professor Beatrice Severino

  24. Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds

    Article • Bioorganic & Medicinal Chemistry, June 2008, Elsevier

    Professor Beatrice Severino

  25. ChemInform Abstract: Design and Synthesis of Potential β-Sheet Nucleators via Suzuki Coupling Reaction.

    Article • ChemInform, April 2008, Wiley

    Professor Beatrice Severino

  26. Synthesis and Pharmacological Evaluations of Sildenafil Analogues for Treatment of Erectile Dysfunction

    Article • Journal of Medicinal Chemistry, April 2008, American Chemical Society (ACS)

    Professor Edson Antunes, Professor Beatrice Severino

  27. Synthesis andIn-vitroPharmacological Evaluation of New 5-HT1AReceptor Ligands Containing a Benzotriazinone Nucleus

    Article • Archiv der Pharmazie, January 2008, Wiley

    Professor Beatrice Severino

  28. Design and synthesis of potential β-sheet nucleators via Suzuki coupling reaction

    Article • Tetrahedron, December 2007, Elsevier

    Professor Beatrice Severino

  29. Microwave Solvent-Free Regioselective 1,3-Dipolar Cycloaddition in the Synthesis of 1,4-Substituted[1,2,3]-triazoles as Amide Bond Isosteres.

    Article • ChemInform, November 2007, Wiley

    Professor Beatrice Severino

  30. Pharmacokinetic Profile of Atenolol Aspirinate

    Article • Archiv der Pharmazie, September 2007, Wiley

    Professor Beatrice Severino

  31. Microwave solvent free regioselective 1,3 dipolar cycloaddition in the synthesis of 1,4 substituted [1,2,3]-triazoles as amide bond isosteres

    Article • Journal of Heterocyclic Chemistry, July 2007, Wiley

    Professor Beatrice Severino

  32. Effect of positive charge in VIP16γ-glutamyl diamino derivatives on hVPAC1 and hVPAC2 receptor function

    Article • Journal of Peptide Science, January 2007, Wiley

    Professor Beatrice Severino

  33. Conformation–activity relationship of peptide T and new pseudocyclic hexapeptide analogs

    Article • Journal of Peptide Science, January 2007, Wiley

    Professor Beatrice Severino

  34. Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage

    Article • Journal of Medicinal Chemistry, December 2006, American Chemical Society (ACS)

    Professor Beatrice Severino

  35. Synthesis by Microwave Irradiation and Antidiarrhoeal Activity of Benzotriazinone and Saccharine Derivatives.

    Article • ChemInform, March 2006, Wiley

    Professor Beatrice Severino

  36. Synthesis, Pharmacological Evaluation, and Molecular Modeling Studies of Novel Peptidic CAAX Analogues as Farnesyl-Protein-Transferase Inhibitors

    Article • Journal of Medicinal Chemistry, March 2006, American Chemical Society (ACS)

    Professor Beatrice Severino

  37. Effects ofN- andC-terminal addition of oligolysines or native loop residues on the biophysical properties of transmembrane domain peptides from a G-protein coupled receptor

    Article • Journal of Peptide Science, January 2006, Wiley

    Professor Beatrice Severino

  38. Synthesis by Microwave Irradiation and Antidiarrhoeal Activity of Benzotriazinone and Saccharine Derivatives

    Article • Archiv der Pharmazie, November 2005, Wiley

    Professor Beatrice Severino

  39. New 5-Hydroxytryptamine 1A Receptor Ligands Containing a Norbornene Nucleus:  Synthesis and in Vitro Pharmacological Evaluation

    Article • Journal of Medicinal Chemistry, August 2005, American Chemical Society (ACS)

    Professor Beatrice Severino

  40. Efficient Microwave Combinatorial Parallel and Nonparallel Synthesis of N-Alkylated Glycine Methyl Esters as Peptide Building Blocks

    Article • Journal of Combinatorial Chemistry, July 2005, American Chemical Society (ACS)

    Professor Beatrice Severino

  41. Synthetic peptides as probes for conformational preferences of domains of membrane receptors

    Article • Biopolymers, January 2005, Wiley

    Professor Beatrice Severino

  42. A Valuable Synthesis of Reduced Peptide Bond by Microwave Irradiation

    Article • QSAR & Combinatorial Science, December 2004, Wiley

    Professor Beatrice Severino

  43. Synthesis by microwave irradiation of a substituted benzoxazine parallel library with preferential relaxant activity for guinea pig trachealis

    Article • European Journal of Medicinal Chemistry, October 2004, Elsevier

    Professor Beatrice Severino

  44. Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats

    Article • Neuropharmacology, March 2004, Elsevier

    Professor Beatrice Severino

  45. Synthesis of N α -Fmoc N , N ′-bis-Boc-5-, 6- and 8-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (5-GTIC, 6-GTIC and 8-GTIC)

    Article • Synthesis, January 2004, Thieme Publishing Group

    Professor Beatrice Severino

  46. PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation

    Article • Hepatology, January 2004, Wiley

    Professor Beatrice Severino

  47. A convenient strategy of dimerization by microwave heating and using 2,5-diketopiperazine as scaffold

    Article • Tetrahedron Letters, February 2003, Elsevier

    Professor Beatrice Severino

  48. A convenient synthesis by microwave irradiation of an active metabolite (EXP-3174) of losartan

    Article • Tetrahedron Letters, February 2003, Elsevier

    Professor Beatrice Severino

  49. A convenient synthesis by microwave heating and pharmacological evaluation of novel benzoyltriazole and saccharine derivatives as 5-HT1A receptor ligands

    Article • European Journal of Pharmaceutical Sciences, July 2002, Elsevier

    Professor Beatrice Severino

  50. Design of Inhibitors for Human Tissue Kallikrein Using Non-Natural Aromatic and Basic Amino Acids

    Article • Biological Chemistry, May 2002, De Gruyter

    Professor Beatrice Severino

  51. Minimal structural requirements for agonist activity of PAR-2 activating peptides

    Article • Bioorganic & Medicinal Chemistry Letters, January 2002, Elsevier

    Professor Beatrice Severino

  52. Synthesis of novel anti-inflammatory peptides derived from the amino-acid sequence of the bioactive protein SV-IV

    Article • European Journal of Biochemistry, June 2001, Wiley

    Professor Beatrice Severino

  53. A convenient synthesis of N-Fmoc-N,N′-bis-Boc-7-guanyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (Fmoc-N,N′-bis-Boc-7-guanyl-Tic-OH, GTIC)

    Article • Tetrahedron Letters, May 2001, Elsevier

    Professor Beatrice Severino

  54. Probing the shape of a hydrophobic pocket in the active site of?-opioid antagonists

    Article • Journal of Peptide Science, January 2001, Wiley

    Professor Beatrice Severino

  55. Synthesis and structure–activity of antisense peptides corresponding to the region for CaM-binding domain of the inducible nitric oxide synthase1Symbols and abbreviations are in accord with recommendations from [1]

    Article • European Journal of Medicinal Chemistry, August 2000, Elsevier

    Professor Beatrice Severino

  56. Synthesis of new 1,2,3-benzotriazin-4-one-arylpiperazine derivatives as 5-HT1A serotonin receptor ligands

    Article • Bioorganic & Medicinal Chemistry, March 2000, Elsevier

    Professor Beatrice Severino

  57. Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids

    Article • Il Farmaco, November 1999, Elsevier

    Professor Beatrice Severino

  58. Influence of Natural Loop Residues or Oligolysines on the Biophysical Properties of Transmembrane Domains of a G Protein-Coupled Receptor

    Article • Springer Science + Business Media

    Professor Beatrice Severino