All Stories

  1. Effect of IAPP on the proteome of cultured Rin-5F cells

    Article • BMC Biochemistry, November 2018, Springer Science + Business Media

    Prof. Andrew Doig

  2. Alzheimer's Disease progresses as a series of cycles.

    Article • Journal of Alzheimer s Disease, October 2018, IOS Press

    Prof. Andrew Doig

  3. Drug repurposing: progress, challenges and recommendations

    Article • Nature Reviews Drug Discovery, October 2018, Springer Science + Business Media

    Prof. Andrew Doig

  4. Amyloid-β/Drug Interactions from Computer Simulations and Cell-Based Assays

    Article • Journal of Alzheimer s Disease, June 2018, IOS Press

    Prof. Andrew Doig

  5. Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer’s Disease?

    Article • ACS Chemical Neuroscience, June 2017, American Chemical Society (ACS)

    Prof. Andrew Doig

  6. Properties of genes essential for mouse development

    Article • PLoS ONE, May 2017, PLOS

    Prof. Andrew Doig

  7. Frozen, but no accident - why the 20 standard amino acids were selected

    Article • FEBS Journal, January 2017, Wiley

    Prof. Andrew Doig

  8. Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies

    Article • Analytical Chemistry, December 2016, American Chemical Society (ACS)

    Professor Volker Deckert, Prof. Andrew Doig

  9. Determination of Protein Secondary Structure from Infrared Spectra Using Partial Least-Squares Regression

    Article • Biochemistry, June 2016, American Chemical Society (ACS)

    Prof. Andrew Doig

  10. Combined Experimental and Simulation Studies Suggest a Revised Mode of Action of the Anti-Alzheimer Disease Drug NQ-Trp

    Article • Chemistry - A European Journal, July 2015, Wiley

    Prof. Andrew Doig

  11. Properties of Protein Drug Target Classes

    Article • PLoS ONE, March 2015, PLOS

    Prof. Andrew Doig

  12. Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

    Article • Chemical Reviews, March 2015, American Chemical Society (ACS)

    Prof. Andrew Doig

  13. Molecular structure of the NQTrp inhibitor with the Alzheimer Aβ1-28 monomer

    Article • European Journal of Medicinal Chemistry, February 2015, Elsevier

    Prof. Andrew Doig

  14. Inhibition of protein aggregation and amyloid formation by small molecules

    Article • Current Opinion in Structural Biology, February 2015, Elsevier

    Prof. Andrew Doig

  15. Maximising the Size of Non-Redundant Protein Datasets Using Graph Theory

    Article • PLoS ONE, February 2013, PLOS

    Prof. Andrew Doig

  16. The N-Methylated Peptide SEN304 Powerfully Inhibits Aβ(1–42) Toxicity by Perturbing Oligomer Formation

    Article • Biochemistry, October 2012, American Chemical Society (ACS)

    Prof Claire E Eyers, Prof. Andrew Doig

  17. Random-Coil:α-Helix Equilibria as a Reporter for the LewisX-LewisX Interaction

    Article • Angewandte Chemie International Edition, September 2011, Wiley

    Prof. Andrew Doig

  18. Determination of protein fold class from Raman or Raman optical activity spectra using random forests

    Article • Protein Science, August 2011, Wiley

    Prof. Andrew Doig

  19. Local control of a disorder–order transition in 4E-BP1 underpins regulation of translation via eIF4E

    Article • Proceedings of the National Academy of Sciences, September 2010, Proceedings of the National Academy of Sciences

    Prof. Andrew Doig

  20. Accurate Determination of Protein Secondary Structure Content from Raman and Raman Optical Activity Spectra

    Article • Analytical Chemistry, August 2010, American Chemical Society (ACS)

    Prof. Andrew Doig

  21. Amyloidogenic sequences in native protein structures

    Article • Protein Science, February 2010, Wiley

    Prof. Andrew Doig

  22. Properties and identification of antibiotic drug targets

    Article • BMC Bioinformatics, January 2010, Springer Science + Business Media

    Prof. Andrew Doig

  23. Inhibitors of protein aggregation and toxicity

    Article • Biochemical Society Transactions, August 2009, Portland Press Ltd.

    Prof. Andrew Doig, Professor David Middleton

  24. Sequence and Structural Features of Enzymes and their Active Sites by EC Class

    Article • Journal of Molecular Biology, March 2009, Elsevier

    Prof. Andrew Doig

  25. Properties and identification of human protein drug targets

    Article • Bioinformatics, January 2009, Oxford University Press (OUP)

    Prof. Andrew Doig

  26. SitesIdentify: a protein functional site prediction tool

    Article • BMC Bioinformatics, January 2009, Springer Science + Business Media

    Prof. Andrew Doig

  27. Effect of the N2 residue on the stability of the α-helix for all 20 amino acids

    Article • Protein Science, December 2008, Wiley

    Prof. Andrew Doig

  28. Structures of N-termini of helices in proteins

    Article • Protein Science, December 2008, Wiley

    Prof. Andrew Doig

  29. Statistical Thermodynamics of the Collagen Triple-Helix/Coil Transition. Free Energies for Amino Acid Substitutions within the Triple-Helix

    Article • The Journal of Physical Chemistry B, November 2008, American Chemical Society (ACS)

    Prof. Andrew Doig

  30. Design of an N-Methylated Peptide Inhibitor of α-Synuclein Aggregation Guided by Solid-State NMR§

    Article • Journal of the American Chemical Society, June 2008, American Chemical Society (ACS)

    Prof. Andrew Doig, Professor David Middleton

  31. Fewer academics could be the answer to insufficient grants

    Article • Nature, June 2008, Springer Science + Business Media

    Prof. Andrew Doig

  32. The effects of α-synuclein on phospholipid vesicle integrity: a study using31P NMR and electron microscopy

    Article • Molecular Membrane Biology, January 2008, Taylor & Francis

    Prof. Andrew Doig, Professor David Middleton

  33. Stability and Design of α-Helical Peptides

    Article • January 2008, Elsevier

    Prof. Andrew Doig

  34. N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure†

    Article • Biochemistry, August 2006, American Chemical Society (ACS)

    Prof. Andrew Doig

  35. The CXXC motif at the N terminus of an α-helical peptide

    Article • Protein Science, August 2006, Wiley

    Prof. Andrew Doig

  36. A Study of the Regional Effects of α-Synuclein on the Organization and Stability of Phospholipid Bilayers†

    Article • Biochemistry, May 2006, American Chemical Society (ACS)

    Prof. Andrew Doig

  37. Studies of the aggregation of an amyloidogenic α-synuclein peptide fragment

    Article • Biochemical Society Transactions, October 2005, Portland Press Ltd.

    Prof. Andrew Doig

  38. Anticooperativity in a Glu−Lys−Glu Salt Bridge Triplet in an Isolated α-Helical Peptide†

    Article • Biochemistry, August 2005, American Chemical Society (ACS)

    Prof. Andrew Doig

  39. A Phosphoserine−Lysine Salt Bridge within an α-Helical Peptide, the Strongest α-Helix Side-Chain Interaction Measured to Date†

    Article • Biochemistry, May 2005, American Chemical Society (ACS)

    Prof. Andrew Doig

  40. A Simple Approach to Normalization for Spectroscopic Data Mining

    Article • Applied Spectroscopy, April 2005, SAGE Publications

    Prof. Andrew Doig

  41. Pairwise Coupling in an Arg-Phe-Met Triplet Stabilizes α-Helical Peptide via Shared Rotamer Preferences

    Article • Journal of the American Chemical Society, April 2005, American Chemical Society (ACS)

    Prof. Andrew Doig

  42. Predicting Enzyme Class From Protein Structure Without Alignments

    Article • Journal of Molecular Biology, January 2005, Elsevier

    Prof. Andrew Doig

  43. The aggregation and membrane-binding properties of an α-synuclein peptide fragment

    Article • Biochemical Society Transactions, November 2004, Portland Press Ltd.

    Prof. Andrew Doig

  44. Prediction of Protein Function in the Absence of Significant Sequence Similarity

    Article • Current Medicinal Chemistry, August 2004, Bentham Science Publishers

    Prof. Andrew Doig

  45. Improved prediction for N-termini of α-helices using empirical information

    Article • Proteins Structure Function and Bioinformatics, July 2004, Wiley

    Prof. Andrew Doig

  46. Prediction of Saccharomyces cerevisiae protein functional class from functional domain composition

    Article • Bioinformatics, February 2004, Oxford University Press (OUP)

    Prof. Andrew Doig

  47. Effect of the N3 residue on the stability of the  -helix

    Article • Protein Science, January 2004, Wiley

    Prof. Andrew Doig

  48. Length preferences and periodicity in  -strands. Antiparallel edge  -sheets are more likely to finish in non-hydrogen bonded rings

    Article • Protein Engineering Design and Selection, December 2003, Oxford University Press (OUP)

    Prof. Andrew Doig

  49. Design strategies for anti-amyloid agents

    Article • Current Opinion in Structural Biology, August 2003, Elsevier

    Prof. Andrew Doig

  50. Distinguishing Enzyme Structures from Non-enzymes Without Alignments

    Article • Journal of Molecular Biology, July 2003, Elsevier

    Prof. Andrew Doig

  51. Recent advances in helix–coil theory

    Article • Biophysical Chemistry, December 2002, Elsevier

    Prof. Andrew Doig

  52. Information-Theoretic Analysis of Protein Sequences Shows that Amino Acids Self-cluster

    Article • Journal of Theoretical Biology, October 2002, Elsevier

    Prof. Andrew Doig

  53. Stabilizing Interactions between Aromatic and Basic Side Chains in α-Helical Peptides and Proteins. Tyrosine Effects on Helix Circular Dichroism

    Article • Journal of the American Chemical Society, October 2002, American Chemical Society (ACS)

    Prof. Andrew Doig

  54. Inhibition of toxicity and protofibril formation in the amyloid-β peptide β(25–35) using N-Methylated derivatives

    Article • Biochemical Society Transactions, August 2002, Portland Press Ltd.

    Prof. Andrew Doig

  55. A critical assessment of the secondary structure α-helices and their termini in proteins

    Article • Protein Engineering Design and Selection, July 2002, Oxford University Press (OUP)

    Prof. Andrew Doig

  56. Effect of Phosphorylation on α-Helix Stability as a Function of Position†

    Article • Biochemistry, February 2002, American Chemical Society (ACS)

    Prof. Andrew Doig

  57. Effect of the N1 residue on the stability of the alpha-helix for all 20 amino acids

    Article • Protein Science, March 2001, Wiley

    Prof. Andrew Doig

  58. Rotamer strain energy in protein helices - quantification of a major force opposing protein folding

    Article • Journal of Molecular Biology, January 2001, Elsevier

    Prof. Andrew Doig

  59. Stabilizing nonpolar/polar side-chain interactions in the ?-helix

    Article • Proteins Structure Function and Bioinformatics, January 2001, Wiley

    Prof. Andrew Doig

  60. Is polyproline II helix the killer conformation? a raman optical activity study of the amyloidogenic prefibrillar intermediate of human lysozyme 1 1Edited by A. R. Fersht

    Article • Journal of Molecular Biology, August 2000, Elsevier

    Prof. Andrew Doig

  61. Inhibition of Toxicity in the β-Amyloid Peptide Fragment β-(25–35) UsingN-Methylated Derivatives

    Article • Journal of Biological Chemistry, May 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Andrew Doig

  62. Periodicity in α-helix lengths and C-capping preferences 1 1Edited by J. M. Thornton

    Article • Journal of Molecular Biology, November 1999, Elsevier

    Prof. Andrew Doig

  63. The α-helix folds on the millisecond time scale

    Article • Proceedings of the National Academy of Sciences, June 1999, Proceedings of the National Academy of Sciences

    Prof. Andrew Doig

  64. Side-chain structures in the first turn of the α-helix 1 1Edited by J. M. Thornton

    Article • Journal of Molecular Biology, March 1999, Elsevier

    Prof. Andrew Doig

  65. Addition of side-chain interactions to 310-helix/coil and α-helix/310-helix/coil theory

    Article • Protein Science, November 1998, Wiley

    Prof. Andrew Doig

  66. Improving the Efficiency of the Genetic Code by Varying the Codon Length—The Perfect Genetic Code

    Article • Journal of Theoretical Biology, October 1997, Elsevier

    Prof. Andrew Doig

  67. Free energies of amino acid side-chain rotamers in α-helices, β-sheets and α-helix N-caps 1 1Edited by A. R. Fersht

    Article • Journal of Molecular Biology, September 1997, Elsevier

    Prof. Andrew Doig

  68. Hydrogen bonding interactions between glutamine and asparagine in α-helical peptides 1 1Edited by A. R. Fersht

    Article • Journal of Molecular Biology, September 1997, Elsevier

    Prof. Andrew Doig

  69. Thermodynamics of amino acid side-chain internal rotations

    Article • Biophysical Chemistry, October 1996, Elsevier

    Prof. Andrew Doig

  70. Models for the 310-helix/coil, π-helix/coil, and α-helix/310-helix/coil transitions in isolated peptides

    Article • Protein Science, August 1996, Wiley

    Prof. Andrew Doig

  71. Addition of side chain interactions to modified Lifson-Roig helix-coil theory: Application to energetics of Phenylalanine-Methionine interactions

    Article • Protein Science, November 1995, Wiley

    Prof. Andrew Doig

  72. Side-chain conformational entropy in protein folding

    Article • Protein Science, November 1995, Wiley

    Prof. Andrew Doig

  73. N- and C-capping preferences for all 20 amino acids in α-helical peptides

    Article • Protein Science, July 1995, Wiley

    Prof. Andrew Doig

  74. Determination of Free Energies of N-Capping in .alpha.-Helixes by Modification of the Lifson-Roig Helix-Coil Theory To Include N- and C-Capping

    Article • Biochemistry, March 1994, American Chemical Society (ACS)

    Prof. Andrew Doig

  75. Helix capping propensities in peptides parallel those in proteins.

    Article • Proceedings of the National Academy of Sciences, December 1993, Proceedings of the National Academy of Sciences

    Prof. Andrew Doig

  76. Why water-soluble, compact, globular proteins have similar specific enthalpies of unfolding at 110.degree.C

    Article • Biochemistry, October 1992, American Chemical Society (ACS)

    Prof. Andrew Doig

  77. Is the hydrophobic effect stabilizing or destabilizing in proteins?

    Article • Journal of Molecular Biology, January 1991, Elsevier

    Prof. Andrew Doig

  78. Surface areas of unfolded proteins

    Article • Nature, November 1990, Springer Science + Business Media

    Prof. Andrew Doig

  79. Structure and Stability of the α-Helix: Lessons for Design

    Article • Springer Science + Business Media

    Prof. Andrew Doig