All Stories

  1. Herba Sideritis: Insights from a Herbal Monograph with Particular Reference to Adaptogenic Potential in Neurodegenerative Disorders and Aging-related Cognitive Decline, Edition 1

    Article • October 2024, Sciencedomain International

    Alexander Panossian

  2. State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives

    Article • Pharmaceuticals, April 2024, MDPI AG

    Alexander Panossian

  3. Botanical hybrid preparations (BHP) in phytomedicine and phytotherapy research: background and perspectives

    Article • March 2024, MDPI AG

    Alexander Panossian

  4. Herba Sideritis: A putative adaptogen for reducing the risk of age-related cognitive decline and neurodegenerative disorders

    Article • Phytomedicine Plus, February 2024, Elsevier

    Alexander Panossian

  5. Efficacy of Kan Jang® in Patients with Mild COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial

    Article • Pharmaceuticals, August 2023, MDPI AG

    Alexander Panossian

  6. Efficacy of Kan Jang® in Patients with Mild COVID-19: a Randomized, Quadruple-Blind, Placebo-Controlled Trial

    Article • August 2023, MDPI AG

    Alexander Panossian

  7. Challenges in phytotherapy research

    Article • Frontiers in Pharmacology, May 2023, Frontiers

    Alexander Panossian

  8. Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics

    Article • Pharmaceuticals, October 2022, MDPI AG

    Alexander Panossian

  9. Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity

    Article • Pharmaceuticals, August 2022, MDPI AG

    Alexander Panossian

  10. Efficacy of Kan Jang® in Patients with Mild COVID-19: Interim Analysis of a Randomized, Quadruple-Blind, Placebo-Controlled Trial

    Article • Pharmaceuticals, August 2022, MDPI AG

    Alexander Panossian

  11. Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial

    Article • Pharmaceuticals, March 2022, MDPI AG

    Alexander Panossian

  12. Phytomedicine mourns the death of its founding editor Professor Hildebert Wagner

    Article • Phytomedicine, January 2022, Elsevier

    Alexander Panossian

  13. Early intervention with Kan Jang® to treat upper-respiratory tract infections: A randomized, quadruple-blind study

    Article • Journal of Traditional and Complementary Medicine, November 2021, Elsevier

    Alexander Panossian

  14. Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics

    Article • Pharmaceuticals, September 2021, MDPI AG

    Alexander Panossian

  15. Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations

    Article • Pharmaceuticals, September 2021, MDPI AG

    Alexander Panossian

  16. Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations

    Article • September 2021, MDPI AG

    Alexander Panossian

  17. Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics

    Article • September 2021, MDPI AG

    Alexander Panossian

  18. Effects of Red and White Ginseng Preparations on Electrical Activity of the Brain in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled, Three-Armed Cross-Over Study

    Article • Pharmaceuticals, February 2021, MDPI AG

    Alexander Panossian

  19. Botanical drugs and supplements affecting the immune response in the time of COVID ‐19: Implications for research and clinical practice

    Article • Phytotherapy Research, December 2020, Wiley

    Alexander Panossian

  20. Evolution of the adaptogenic concept from traditional use to medical systems

    Article • Medicinal Research Reviews, October 2020, Wiley

    Alexander Panossian

  21. The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections

    Article • Pharmaceuticals, September 2020, MDPI AG

    Alexander Panossian

  22. Adaptogens in chemobrain (part IV): adaptogenic plants prevent the chemotherapeutics-induced imbalance of redox homeostasis by modulation of expression of genes encoding Nrf2-mediated signaling proteins and antioxidant, metabolizing, detoxifying enzyme...

    Article • Longhua Chinese Medicine, September 2020, AME Publishing Company

    Alexander Panossian

  23. Panax Ginseng Preparations Enhance Long Term Potentiation In Rat Hippocampal Slices By Glutamatergic NMDA And Kainate Receptor Mediated Transmission

    Article • Alternative Complementary & Integrative Medicine, August 2020, Herald Scholarly Open Access

    Alexander Panossian

  24. Panax Ginseng Meyer Herbal Preparation HRG80 For Preventing And Mitigating Stress-Induced Failure Of Cognitive Functions In Healthy Subjects

    Article • Alternative Complementary & Integrative Medicine, May 2020, Herald Scholarly Open Access

    Alexander Panossian

  25. Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study

    Article • Pharmaceuticals, May 2020, MDPI AG

    Alexander Panossian

  26. Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial

    Article • Phytomedicine, April 2020, Elsevier

    Alexander Panossian

  27. Efficacy of Panax ginseng Meyer Herbal Preparation HRG80 in Preventing and Mitigating Stress-Induced Failure of Cognitive Functions in Healthy Subjects: A Pilot, Randomized, Double-Blind, Placebo-Controlled Crossover Trial

    Article • Pharmaceuticals, March 2020, MDPI AG

    Alexander Panossian

  28. Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study

    Article • Pharmaceuticals, March 2020, MDPI AG

    Alexander Panossian

  29. Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells

    Article • Phytomedicine, July 2019, Elsevier

    Alexander Panossian

  30. Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells

    Article • Phytomedicine, May 2019, Elsevier

    Alexander Panossian

  31. Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment – Transcriptome-wide microarray profiles of neuroglia cells

    Article • Phytomedicine, March 2019, Elsevier

    Alexander Panossian

  32. Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray analysis of neuroglia cells

    Article • Phytomedicine, March 2019, Elsevier

    Alexander Panossian

  33. Synergy assessments of plant extracts used in the treatment of stress and aging-related disorders

    Article • Synergy, December 2018, Elsevier

    Alexander Panossian

  34. Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells

    Article • Phytomedicine, November 2018, Elsevier

    Alexander Panossian

  35. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology

    Article • Phytomedicine, November 2018, Elsevier

    Alexander Panossian

  36. Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory

    Article • Frontiers in Pharmacology, May 2018, Frontiers

    Alexander Panossian

  37. The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome

    Article • Phytochemistry Letters, February 2018, Elsevier

    Alexander Panossian

  38. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals

    Article • Annals of the New York Academy of Sciences, June 2017, Wiley

    Alexander Panossian

  39. Rhodiola rosea L. as a putative botanical antidepressant

    Article • Phytomedicine, June 2016, Elsevier

    Alexander Panossian

  40. Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment

    Article • PLoS ONE, March 2016, PLOS

    Alexander Panossian

  41. Hildebert Wagner Award Laureate announcement December 2015

    Article • Phytomedicine, January 2016, Elsevier

    Alexander Panossian

  42. Nobel Prize for artemisinin brings phytotherapy into the spotlight

    Article • Phytomedicine, December 2015, Elsevier

    Alexander Panossian

  43. Synergy assessment of fixed combinations of Herba Andrographidis and Radix Eleutherococci extracts by transcriptome-wide microarray profiling

    Article • Phytomedicine, October 2015, Elsevier

    Alexander Panossian

  44. Efficacy of Adaptogenic Supplements on Adapting to Stress: A Randomized, Controlled Trial

    Article • Journal of Athletic Enhancement, January 2015, OMICS Publishing Group

    Alexander Panossian

  45. Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: An interactive pathway analysis of the downstream effects using RNA microarray data

    Article • Phytomedicine, September 2014, Elsevier

    Alexander Panossian

  46. Editorial

    Article • Phytomedicine, June 2014, Elsevier

    Alexander Panossian

  47. 18 years with Phytomedicine!

    Article • Phytomedicine, May 2014, Elsevier

    Alexander Panossian

  48. Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts

    Article • Phytomedicine, November 2013, Elsevier

    Alexander Panossian

  49. Synergy and antagonism of active constituents in a complex herbal formulation on metabolic regulation at a transcriptional level

    Article • Planta Medica, August 2013, Thieme Publishing Group

    Alexander Panossian

  50. Understanding adaptogens: new evidence on their possible effectiveness in stress-induced and ageing-associated disorders from a DNA microarray study of neuroglia cells

    Article • Planta Medica, August 2013, Thieme Publishing Group

    Alexander Panossian

  51. Adaptogens in Mental and Behavioral Disorders

    Article • Psychiatric Clinics of North America, March 2013, Elsevier

    Alexander Panossian

  52. Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells

    Article • Frontiers in Neuroscience, January 2013, Frontiers

    Alexander Panossian

  53. Innate defense response stimulated by ADAPT-232 in nueroglia cells augments tolerance and adaptation to stress

    Article • Planta Medica, July 2012, Thieme Publishing Group

    Alexander Panossian

  54. Adaptogens Stimulate Neuropeptide Y and Hsp72 Expression and Release in Neuroglia Cells

    Article • Frontiers in Neuroscience, January 2012, Frontiers

    Alexander Panossian

  55. Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence

    Article • European Neuropsychopharmacology, December 2011, Elsevier

    Professor Andrew Scholey, Alexander Panossian

  56. Adaptogens (ADAPT-232) stimulate neuropeptide Y expression in neuroglia cells

    Article • Planta Medica, August 2011, Thieme Publishing Group

    Alexander Panossian

  57. Adaptogens stimulate molecular chaperon Hsp70 expression in neuroglia cells

    Article • Planta Medica, August 2011, Thieme Publishing Group

    Alexander Panossian

  58. Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy

    Article • Phytomedicine, June 2010, Elsevier

    Alexander Panossian

  59. Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions

    Article • Phytomedicine, June 2010, Elsevier

    Alexander Panossian

  60. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity

    Article • Pharmaceuticals, January 2010, MDPI AG

    Alexander Panossian

  61. Molecular Chaperones as Mediators of Stress Protective Effect of Plant Adaptogens

    Article • November 2009, Springer Science + Business Media

    Alexander Panossian

  62. Evidence-Based Efficacy of Adaptogens in Fatigue, and Molecular Mechanisms Related to their Stress-Protective Activity

    Article • Current Clinical Pharmacology, September 2009, Bentham Science Publishers

    Alexander Panossian

  63. A randomised, double-blind, placebo controlled, parallel group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue

    Article • Planta Medica, July 2009, Thieme Publishing Group

    Alexander Panossian

  64. Evidence based efficacy of adaptogens in fatigue

    Article • Planta Medica, July 2009, Thieme Publishing Group

    Alexander Panossian

  65. Molecular chaperons mediated pathways of stress protective and anti-aging effects of adaptogens

    Article • Planta Medica, July 2009, Thieme Publishing Group

    Alexander Panossian

  66. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones

    Article • Phytomedicine, June 2009, Elsevier

    Alexander Panossian

  67. A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Standardised Extract SHR-5 of the Roots ofRhodiola roseain the Treatment of Subjects with Stress-Related Fatigue

    Article • Planta Medica, November 2008, Thieme Publishing Group

    Alexander Panossian

  68. Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats

    Article • Phytotherapy Research, October 2008, Wiley

    Alexander Panossian

  69. Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine

    Article • Journal of Ethnopharmacology, July 2008, Elsevier

    Alexander Panossian

  70. Adaptogens exert a stress protective effect by modulation of expression of molecular chaperons

    Article • Planta Medica, July 2008, Thieme Publishing Group

    Alexander Panossian

  71. Comparative study of Rhodiola preparations on behavioral despair of rats

    Article • Phytomedicine, January 2008, Elsevier

    Alexander Panossian

  72. Clinical trial ofRhodiola roseaL. extract SHR-5 in the treatment of mild to moderate depression

    Article • Nordic Journal of Psychiatry, January 2007, Taylor & Francis

    Alexander Panossian

  73. Efficacy of Slim339® in reducing body weight of overweight and obese human subjects

    Article • Phytotherapy Research, January 2007, Wiley

    Alexander Panossian

  74. Erratum

    Article • Nordic Journal of Psychiatry, January 2007, Taylor & Francis

    Alexander Panossian

  75. Rhodiola SHR-5 extract and the treatment of depression

    Article • Planta Medica, January 2007, Thieme Publishing Group

    Alexander Panossian

  76. The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol

    Article • Drug Target Insights, January 2007, Aboutscience Srl

    Alexander Panossian

  77. The efficacy of multi-drug therapy for the common cold with particular reference to Kan Jang fixed combination

    Article • Planta Medica, January 2007, Thieme Publishing Group

    Alexander Panossian

  78. Adaptogens modify stress response by suppressing the increase of p-SAPK, nitric oxide and cortisone in the blood of rabbits

    Article • Planta Medica, August 2006, Thieme Publishing Group

    Alexander Panossian

  79. The effect of Kan Jang extract on the pharmacokinetics and pharmacodynamics of warfarin in rats

    Article • Phytomedicine, May 2006, Elsevier

    Alexander Panossian

  80. The New Medical “Missionaries” — Grooming the Next Generation of Global Health Workers

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, April 2006, New England Journal of Medicine (NEJM/MMS)

    Alexander Panossian

  81. Methods of phytochemical standardisation of rhizoma cimicifugae racemosae

    Article • Phytochemical Analysis, March 2006, Wiley

    Alexander Panossian

  82. Impact of Chisan® (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia

    Article • Phytomedicine, November 2005, Elsevier

    Alexander Panossian

  83. Randomized trial of a fixed combination (KanJang®) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections

    Article • Phytomedicine, August 2005, Elsevier

    Alexander Panossian

  84. A phase I clinical study of Andrographis paniculata fixed combination Kan Jang™ versus ginseng and valerian on the semen quality of healthy male subjects

    Article • Phytomedicine, June 2005, Elsevier

    Alexander Panossian

  85. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration

    Article • Phytotherapy Research, January 2005, Wiley

    Alexander Panossian

  86. Methods of phytochemical standardisation of rhizomaCimicifugae racemosae

    Article • Phytochemical Analysis, March 2004, Wiley

    Alexander Panossian

  87. Plasma nitric oxide level in familial Mediterranean fever and its modulations by Immuno-Guard

    Article • Nitric Oxide, September 2003, Elsevier

    Alexander Panossian

  88. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard® – a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts ...

    Article • Phytomedicine, January 2003, Elsevier

    Alexander Panossian

  89. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis

    Article • Phytomedicine, January 2002, Elsevier

    Alexander Panossian

  90. Effect of Andrographolide and Kan Jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture

    Article • Phytomedicine, January 2002, Elsevier

    Alexander Panossian

  91. Analysis of Aromatic Aldehydes in Brandy and Wine by High-Performance Capillary Electrophoresis

    Article • Analytical Chemistry, August 2001, American Chemical Society (ACS)

    Alexander Panossian

  92. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human

    Article • Phytomedicine, October 2000, Elsevier

    Alexander Panossian

  93. Rhodiola rosea in stress induced fatigue — A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty

    Article • Phytomedicine, October 2000, Elsevier

    Alexander Panossian

  94. Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of action

    Article • Phytomedicine, October 1999, Elsevier

    Alexander Panossian

  95. Effect of Andrographis paniculata extract on progesterone in blood plasma of pregnant rats

    Article • Phytomedicine, July 1999, Elsevier

    Alexander Panossian

  96. On the mechanism of action of plant adaptogens with particular reference to Cucurbitacin R diglucoside

    Article • Phytomedicine, July 1999, Elsevier

    Alexander Panossian

  97. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva

    Article • Phytomedicine, March 1999, Elsevier

    Alexander Panossian

  98. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation

    Article • Phytomedicine, March 1999, Elsevier

    Alexander Panossian

  99. Restoration of the Disordered Glucose-Fatty Acid Cycle in Alloxan-Diabetic Rats by Trihydroxyoctadecadienoic Acids fromBryonia alba, a Native Armenian Medicinal Plant

    Article • Planta Medica, June 1998, Thieme Publishing Group

    Alexander Panossian

  100. Criminalization of perinatal HIV transmission

    Article • Journal of Legal Medicine, June 1998, Taylor & Francis

    Alexander Panossian

  101. Pharmacological activity of phenylpropanoids of the mistletoe, Viscum album L., host: Pyrus caucasica Fed

    Article • Phytomedicine, March 1998, Elsevier

    Alexander Panossian

  102. Beditine, a new benzodioxane derivative, as a suppressor of human polymorphonuclear leukocyte and platelet activation

    Article • Biochemical Pharmacology, June 1997, Elsevier

    Alexander Panossian

  103. Plant adaptogens. II. Bryonia as an adaptogen

    Article • Phytomedicine, March 1997, Elsevier

    Alexander Panossian

  104. Dose-dependent reversal effects of Capsaicin on Interleukin-1α production is associated with the metabolism of arachidonic acid (leukotriene B4 and prostaglandin E2) as well as nitric oxide production in human leukocytes

    Article • Phytomedicine, September 1996, Elsevier

    Alexander Panossian

  105. Immunosuppressive effects of hypericin on stimulated human leukocytes: inhibition of the arachidonic acid release, leukotriene B4 and Interleukin-Iα production, and activation of nitric oxide formation

    Article • Phytomedicine, May 1996, Elsevier

    Alexander Panossian

  106. Marchantin B from the liverwort Marchantia polymorpha selectively inhibits the biosynthesis of 5-lipoxygenase products and the release of arachidonic acid in Ca+2 ionophore A 23187 stimulated human granulocytes

    Article • Phytomedicine, March 1996, Elsevier

    Alexander Panossian

  107. Dose dependent reversal effects of plumbagin on metabolism of arachidonic acid in porcine polymorphonuclear leukocytes

    Article • Phytomedicine, April 1995, Elsevier

    Alexander Panossian

  108. Trihydroxyoctadecadienoic acids exhibit antiatherosclerotic and antiatherogenic activity

    Article • Phytomedicine, September 1994, Elsevier

    Alexander Panossian

  109. Oxyradical-mediated chromosome damage in patients with familial mediterranean fever

    Article • Free Radical Biology and Medicine, September 1993, Elsevier

    Alexander Panossian

  110. Search for prostaglandins and related compounds in plants

    Article • Prostaglandins, March 1987, Elsevier

    Alexander Panossian

  111. Unsaturated Polyhydroxy Acids having Prostaglandin-Like Activity from Bryonia alba II. Major Components

    Article • Planta Medica, January 1983, Thieme Publishing Group

    Alexander Panossian

  112. On the mechanism of biosynthesis of leukotrienes and related compounds

    Article • FEBS Letters, December 1982, Wiley

    Alexander Panossian