All Stories

  1. Botanical drugs and supplements affecting the immune response in the time of COVID ‐19: Implications for research and clinical practice

    Article • Phytotherapy Research, December 2020, Wiley

    Alexander Panossian

  2. Evolution of the adaptogenic concept from traditional use to medical systems

    Article • Medicinal Research Reviews, October 2020, Wiley

    Alexander Panossian

  3. The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections

    Article • Pharmaceuticals, September 2020, MDPI AG

    Alexander Panossian

  4. Adaptogens in chemobrain (part IV): adaptogenic plants prevent the chemotherapeutics-induced imbalance of redox homeostasis by modulation of expression of genes encoding Nrf2-mediated signaling proteins and antioxidant, metabolizing, detoxifying enzyme...

    Article • Longhua Chinese Medicine, September 2020, AME Publishing Company

    Alexander Panossian

  5. Panax Ginseng Preparations Enhance Long Term Potentiation In Rat Hippocampal Slices By Glutamatergic NMDA And Kainate Receptor Mediated Transmission

    Article • Alternative Complementary & Integrative Medicine, August 2020, Herald Scholarly Open Access

    Alexander Panossian

  6. Panax Ginseng Meyer Herbal Preparation HRG80 For Preventing And Mitigating Stress-Induced Failure Of Cognitive Functions In Healthy Subjects

    Article • Alternative Complementary & Integrative Medicine, May 2020, Herald Scholarly Open Access

    Alexander Panossian

  7. Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study

    Article • Pharmaceuticals, May 2020, MDPI AG

    Alexander Panossian

  8. Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial

    Article • Phytomedicine, April 2020, Elsevier

    Alexander Panossian

  9. Efficacy of Panax ginseng Meyer Herbal Preparation HRG80 in Preventing and Mitigating Stress-Induced Failure of Cognitive Functions in Healthy Subjects: A Pilot, Randomized, Double-Blind, Placebo-Controlled Crossover Trial

    Article • Pharmaceuticals, March 2020, MDPI AG

    Alexander Panossian

  10. Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study

    Article • Pharmaceuticals, March 2020, MDPI AG

    Alexander Panossian

  11. Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells

    Article • Phytomedicine, July 2019, Elsevier

    Alexander Panossian

  12. Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells

    Article • Phytomedicine, May 2019, Elsevier

    Alexander Panossian

  13. Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment – Transcriptome-wide microarray profiles of neuroglia cells

    Article • Phytomedicine, March 2019, Elsevier

    Alexander Panossian

  14. Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray analysis of neuroglia cells

    Article • Phytomedicine, March 2019, Elsevier

    Alexander Panossian

  15. Synergy assessments of plant extracts used in the treatment of stress and aging-related disorders

    Article • Synergy, December 2018, Elsevier

    Alexander Panossian

  16. Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells

    Article • Phytomedicine, November 2018, Elsevier

    Alexander Panossian

  17. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology

    Article • Phytomedicine, November 2018, Elsevier

    Alexander Panossian

  18. The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome

    Article • Phytochemistry Letters, February 2018, Elsevier

    Alexander Panossian

  19. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals

    Article • Annals of the New York Academy of Sciences, June 2017, Wiley

    Alexander Panossian

  20. Rhodiola rosea L. as a putative botanical antidepressant

    Article • Phytomedicine, June 2016, Elsevier

    Alexander Panossian

  21. Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment

    Article • PLoS ONE, March 2016, PLOS

    Alexander Panossian

  22. Synergy assessment of fixed combinations of Herba Andrographidis and Radix Eleutherococci extracts by transcriptome-wide microarray profiling

    Article • Phytomedicine, October 2015, Elsevier

    Alexander Panossian

  23. Efficacy of Adaptogenic Supplements on Adapting to Stress: A Randomized, Controlled Trial

    Article • Journal of Athletic Enhancement, January 2015, OMICS Publishing Group

    Alexander Panossian

  24. Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: An interactive pathway analysis of the downstream effects using RNA microarray data

    Article • Phytomedicine, September 2014, Elsevier

    Alexander Panossian

  25. Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts

    Article • Phytomedicine, November 2013, Elsevier

    Alexander Panossian

  26. Adaptogens in Mental and Behavioral Disorders

    Article • Psychiatric Clinics of North America, March 2013, Elsevier

    Alexander Panossian

  27. Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells

    Article • Frontiers in Neuroscience, January 2013, Frontiers

    Alexander Panossian

  28. Adaptogens Stimulate Neuropeptide Y and Hsp72 Expression and Release in Neuroglia Cells

    Article • Frontiers in Neuroscience, January 2012, Frontiers

    Alexander Panossian

  29. Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence

    Article • European Neuropsychopharmacology, December 2011, Elsevier

    Professor Andrew Scholey, Alexander Panossian

  30. Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy

    Article • Phytomedicine, June 2010, Elsevier

    Alexander Panossian

  31. Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions

    Article • Phytomedicine, June 2010, Elsevier

    Alexander Panossian

  32. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones

    Article • Phytomedicine, June 2009, Elsevier

    Alexander Panossian

  33. A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Standardised Extract SHR-5 of the Roots ofRhodiola roseain the Treatment of Subjects with Stress-Related Fatigue

    Article • Planta Medica, November 2008, Thieme Publishing Group

    Alexander Panossian

  34. Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats

    Article • Phytotherapy Research, October 2008, Wiley

    Alexander Panossian

  35. Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine

    Article • Journal of Ethnopharmacology, July 2008, Elsevier

    Alexander Panossian

  36. Comparative study of Rhodiola preparations on behavioral despair of rats

    Article • Phytomedicine, January 2008, Elsevier

    Alexander Panossian

  37. Clinical trial ofRhodiola roseaL. extract SHR-5 in the treatment of mild to moderate depression

    Article • Nordic Journal of Psychiatry, January 2007, Taylor & Francis

    Alexander Panossian

  38. Efficacy of Slim339® in reducing body weight of overweight and obese human subjects

    Article • Phytotherapy Research, January 2007, Wiley

    Alexander Panossian

  39. The effect of Kan Jang extract on the pharmacokinetics and pharmacodynamics of warfarin in rats

    Article • Phytomedicine, May 2006, Elsevier

    Alexander Panossian

  40. The New Medical “Missionaries” — Grooming the Next Generation of Global Health Workers

    Article • New England Journal of Medicine, April 2006, New England Journal of Medicine (NEJM/MMS)

    Alexander Panossian

  41. Impact of Chisan® (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia

    Article • Phytomedicine, November 2005, Elsevier

    Alexander Panossian

  42. Randomized trial of a fixed combination (KanJang®) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections

    Article • Phytomedicine, August 2005, Elsevier

    Alexander Panossian

  43. A phase I clinical study of Andrographis paniculata fixed combination Kan Jang™ versus ginseng and valerian on the semen quality of healthy male subjects

    Article • Phytomedicine, June 2005, Elsevier

    Alexander Panossian

  44. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration

    Article • Phytotherapy Research, January 2005, Wiley

    Alexander Panossian

  45. Methods of phytochemical standardisation of rhizomaCimicifugae racemosae

    Article • Phytochemical Analysis, March 2004, Wiley

    Alexander Panossian

  46. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard® – a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts ...

    Article • Phytomedicine, January 2003, Elsevier

    Alexander Panossian

  47. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis

    Article • Phytomedicine, January 2002, Elsevier

    Alexander Panossian

  48. Effect of Andrographolide and Kan Jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture

    Article • Phytomedicine, January 2002, Elsevier

    Alexander Panossian

  49. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human

    Article • Phytomedicine, October 2000, Elsevier

    Alexander Panossian

  50. Rhodiola rosea in stress induced fatigue — A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty

    Article • Phytomedicine, October 2000, Elsevier

    Alexander Panossian

  51. Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of action

    Article • Phytomedicine, October 1999, Elsevier

    Alexander Panossian

  52. Effect of Andrographis paniculata extract on progesterone in blood plasma of pregnant rats

    Article • Phytomedicine, July 1999, Elsevier

    Alexander Panossian

  53. On the mechanism of action of plant adaptogens with particular reference to Cucurbitacin R diglucoside

    Article • Phytomedicine, July 1999, Elsevier

    Alexander Panossian

  54. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva

    Article • Phytomedicine, March 1999, Elsevier

    Alexander Panossian

  55. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation

    Article • Phytomedicine, March 1999, Elsevier

    Alexander Panossian

  56. Restoration of the Disordered Glucose-Fatty Acid Cycle in Alloxan-Diabetic Rats by Trihydroxyoctadecadienoic Acids fromBryonia alba, a Native Armenian Medicinal Plant

    Article • Planta Medica, June 1998, Thieme Publishing Group

    Alexander Panossian

  57. Pharmacological activity of phenylpropanoids of the mistletoe, Viscum album L., host: Pyrus caucasica Fed

    Article • Phytomedicine, March 1998, Elsevier

    Alexander Panossian

  58. Plant adaptogens. II. Bryonia as an adaptogen

    Article • Phytomedicine, March 1997, Elsevier

    Alexander Panossian

  59. Dose-dependent reversal effects of Capsaicin on Interleukin-1α production is associated with the metabolism of arachidonic acid (leukotriene B4 and prostaglandin E2) as well as nitric oxide production in human leukocytes

    Article • Phytomedicine, September 1996, Elsevier

    Alexander Panossian

  60. Immunosuppressive effects of hypericin on stimulated human leukocytes: inhibition of the arachidonic acid release, leukotriene B4 and Interleukin-Iα production, and activation of nitric oxide formation

    Article • Phytomedicine, May 1996, Elsevier

    Alexander Panossian

  61. Marchantin B from the liverwort Marchantia polymorpha selectively inhibits the biosynthesis of 5-lipoxygenase products and the release of arachidonic acid in Ca+2 ionophore A 23187 stimulated human granulocytes

    Article • Phytomedicine, March 1996, Elsevier

    Alexander Panossian

  62. Dose dependent reversal effects of plumbagin on metabolism of arachidonic acid in porcine polymorphonuclear leukocytes

    Article • Phytomedicine, April 1995, Elsevier

    Alexander Panossian

  63. Trihydroxyoctadecadienoic acids exhibit antiatherosclerotic and antiatherogenic activity

    Article • Phytomedicine, September 1994, Elsevier

    Alexander Panossian

  64. Unsaturated Polyhydroxy Acids having Prostaglandin-Like Activity from Bryonia alba II. Major Components

    Article • Planta Medica, January 1983, Thieme Publishing Group

    Alexander Panossian