All Stories

  1. A select thiosemicarbazone copper(II) complex induces apoptosis in gastric cancer and targets cancer stem cells reducing pluripotency markers

    Article • European Journal of Medicinal Chemistry, December 2024, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  2. Trans-[Pt(amine)Cl2(PPh3)] Complexes Target Mitochondria and Endoplasmic Reticulum in Gastric Cancer Cells

    Article • International Journal of Molecular Sciences, July 2024, MDPI AG

    Dr ADORACION GOMEZ QUIROGA

  3. Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells

    Article • Communications Biology, March 2024, Springer Science + Business Media

    Dr ADORACION GOMEZ QUIROGA

  4. Proving the Antimicrobial Therapeutic Activity on a New Copper–Thiosemicarbazone Complex

    Article • Molecular Pharmaceutics, March 2024, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  5. Tips and tops of chemical synthesis for Pt(II) complexes

    Article • Dalton Transactions, January 2024, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  6. Dithiobiureas Palladium(II) complexes' studies: From their synthesis to their biological action

    Article • Journal of Inorganic Biochemistry, September 2023, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  7. Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer

    Article • Genes & Diseases, July 2023, Tsinghua University Press

    Professor Carmela Calés, Dr ADORACION GOMEZ QUIROGA

  8. Two novel Pd thiosemicarbazone complexes as efficient and selective antitumoral drugs

    Article • Inorganic Chemistry Frontiers, January 2023, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  9. Two Different Thiosemicarbazone Tauto‐Conformers Coordinate to Palladium (II). Stability and Biological Studies of the Final Complexes

    Article • European Journal of Inorganic Chemistry, February 2021, Wiley

    Dr ADORACION GOMEZ QUIROGA

  10. Chemical and Biological Evaluation of Thiosemicarbazone-Bearing Heterocyclic Metal Complexes

    Article • Current Topics in Medicinal Chemistry, January 2021, Bentham Science Publishers

    Dr ANA I MATESANZ, Dr ADORACION GOMEZ QUIROGA

  11. Thiosemicarbazone Derivatives as Inhibitors of Amyloid-β Aggregation: Effect of Metal Coordination

    Article • Inorganic Chemistry, May 2020, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  12. Exploring DNA binding ability of two novel α-N-heterocyclic thiosemicarbazone palladium(II) complexes

    Article • Journal of Inorganic Biochemistry, February 2020, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  13. New Platinum(II) Triazole Thiosemicarbazone Complexes: Analysis of Their Reactivity and Potential Antitumoral Action

    Article • ChemBioChem, January 2020, Wiley

    Dr ADORACION GOMEZ QUIROGA

  14. New Findings in the Signaling Pathways of cis and trans Platinum Iodido Complexes’ Interaction with DNA of Cancer Cells

    Article • ACS Omega, December 2019, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  15. New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools

    Article • Journal of Experimental & Clinical Cancer Research, June 2019, Springer Science + Business Media

    Dr ADORACION GOMEZ QUIROGA

  16. Versatile Route to trans-Platinum(II) Complexes via Manipulation of a Coordinated 3-(Pyridin-3-yl)propanoic Acid Ligand

    Article • Inorganic Chemistry, April 2019, American Chemical Society (ACS)

    Dr ANA I MATESANZ, Dr ADORACION GOMEZ QUIROGA

  17. Novel structures of platinum complexes bearing N‑bisphosphonates and study of their biological properties

    Article • Journal of Inorganic Biochemistry, February 2019, Elsevier

    Dr ANA I MATESANZ, Dr ADORACION GOMEZ QUIROGA

  18. Four-component relativistic 31P NMR calculations for trans-platinum(ii) complexes: importance of the solvent and dynamics in spectral simulations

    Article • Dalton Transactions, January 2019, Royal Society of Chemistry

    Professor Marcel Swart, Dr ADORACION GOMEZ QUIROGA

  19. Synthesis, Reactivity Studies, and Cytotoxicity of Two trans-Iodidoplatinum(II) Complexes. Does Photoactivation Work?

    Article • Inorganics, December 2018, MDPI AG

    Dr ANA I MATESANZ, Dr ADORACION GOMEZ QUIROGA

  20. Synthesis, Reactivity Studies and Cytotoxicity of Two Iodidoplatinum(II) Complexes. Does Photoactivation Work?

    Article • October 2018, MDPI AG

    Dr ADORACION GOMEZ QUIROGA

  21. XPA, XPC, and XPD Modulate Sensitivity in Gastric Cisplatin Resistance Cancer Cells

    Article • Frontiers in Pharmacology, October 2018, Frontiers

    Dr ADORACION GOMEZ QUIROGA

  22. Reactions of a tetranuclear Pt-thiosemicarbazone complex with model proteins

    Article • Journal of Inorganic Biochemistry, April 2018, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  23. Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes

    Article • Royal Society Open Science, February 2018, Royal Society Publishing

    Dr ADORACION GOMEZ QUIROGA

  24. Mononuclear Pd(ii) and Pt(ii) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

    Article • Inorganic Chemistry Frontiers, January 2018, Royal Society of Chemistry

    Dr ANA I MATESANZ, Dr ADORACION GOMEZ QUIROGA

  25. Enhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligands

    Article • Inorganic Chemistry, May 2017, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  26. Nonconventional trans‐Platinum Complexes Functionalized with RDG Peptides: Chemical and Cytototoxicity Studies

    Article • European Journal of Inorganic Chemistry, February 2017, Wiley

    Dr ADORACION GOMEZ QUIROGA

  27. Combining imaging and anticancer properties with new heterobimetallic Pt(ii)/M(i) (M = Re, 99mTc) complexes

    Article • Dalton Transactions, January 2017, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  28. Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles

    Article • BioMetals, April 2016, Springer Science + Business Media

    Dr ADORACION GOMEZ QUIROGA

  29. Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light

    Article • Journal of Inorganic Biochemistry, December 2015, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  30. Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(ii) complexes

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  31. cis-Pt I2(NH3)2: a reappraisal

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  32. Design and Biological Evaluation of New Platinum(II) Complexes Bearing Ligands with DNA-Targeting Ability

    Article • Inorganic Chemistry, November 2014, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  33. Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II)

    Article • Inorganic Chemistry, July 2014, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  34. Peculiar Features in the Crystal Structure of the Adduct Formed betweencis-PtI2(NH3)2and Hen Egg White Lysozyme

    Article • Inorganic Chemistry, November 2013, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  35. The second generation of iodido complexes: trans-[PtI2(amine)(amine′)] bearing different aliphatic amines

    Article • Journal of Inorganic Biochemistry, October 2013, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  36. anticancer non traditional drugs

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  37. Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand

    Article • Dalton Transactions, January 2013, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA, Dr. José M. Padrón

  38. Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA

    Article • Journal of Inorganic Biochemistry, September 2012, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  39. Reactivity and Biological Properties of a Series of Cytotoxic PtI2(amine)2 Complexes, Either cis or trans Configured

    Article • Inorganic Chemistry, January 2012, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA, Dr. José M. Padrón, Dott Giuseppe Pieraccini

  40. Non-Classical Structures Among Current Platinum Complexes with Potential as Antitumor Drugs

    Article • Current Topics in Medicinal Chemistry, November 2011, Bentham Science Publishers

    Dr ADORACION GOMEZ QUIROGA

  41. Synthesis, characterization and tumor cell growth inhibition of new trans platinum complexes with phosphane derivatives

    Article • Polyhedron, June 2011, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  42. The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicity

    Article • Dalton Transactions, January 2011, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  43. Experimental Validation of the Predictions of a Mathematical Model for Protein Purification and Tag Selection

    Article • Separation Science and Technology, October 2010, Taylor & Francis

    Dr ADORACION GOMEZ QUIROGA

  44. Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides

    Article • Journal of Inorganic Biochemistry, September 2010, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  45. Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel “Rule-Breaker” Iodidoplatinum(II) Complex

    Article • ACS Medicinal Chemistry Letters, July 2010, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA, Dr. José M. Padrón

  46. Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm

    Article • ChemMedChem, June 2010, Wiley

    Dr ADORACION GOMEZ QUIROGA

  47. ChemInform Abstract: Synthesis, Cytotoxic Activities and Proposed Mode of Binding of a Series of Bis{[(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl}alkylamines.

    Article • ChemInform, May 2010, Wiley

    Dr ADORACION GOMEZ QUIROGA

  48. An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(ii) metallo-drug

    Article • Dalton Transactions, January 2010, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA, Professor Alison Rodger

  49. Conjugation of testosterone modifies the interaction of mono-functional cationic platinum(ii) complexes with DNA, causing significant alterations to the DNA helix

    Article • Dalton Transactions, January 2010, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA, Professor Alison Rodger

  50. New reactions of anticancer-platinum complexes and their intriguing behaviour under various experimental conditions

    Article • Dalton Transactions, January 2010, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  51. The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine

    Article • European Journal of Medicinal Chemistry, January 2010, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  52. Solution Behaviour and Biomolecular Interactions of Two Cytotoxictrans-Platinum(II) Complexes Bearing Aliphatic Amine Ligands

    Article • Chemistry - A European Journal, September 2009, Wiley

    Dr ADORACION GOMEZ QUIROGA

  53. Inhibition of p38-MAPK Potentiates Cisplatin-Induced Apoptosis via GSH Depletion and Increases Intracellular Drug Accumulation in Growth-Arrested Kidney Tubular Epithelial Cells

    Article • Toxicological Sciences, July 2009, Oxford University Press (OUP)

    prof alberto ortiz , Dr ADORACION GOMEZ QUIROGA

  54. [1H,15N] NMR studies of the aquation of cis-diamine platinum(II) complexes

    Article • Inorganica Chimica Acta, February 2009, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  55. Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(ii) anticancer complexes

    Article • Dalton Transactions, January 2009, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  56. Influence of (Hydroxymethyl)pyridine and Pyridine-carboxylic Acids, intrans-Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

    Article • Chemistry & Biodiversity, October 2008, Wiley

    Dr ADORACION GOMEZ QUIROGA

  57. Platinum(IV) Complexes of 3‐ and 4‐Picolinic Acids Containing Ammine or Isopropylamine Ligands – Synthesis, Characteri­zation, X‐ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines

    Article • European Journal of Inorganic Chemistry, October 2008, Wiley

    Dr ADORACION GOMEZ QUIROGA

  58. Isolation of an Intermediate in the Platination of p ‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug

    Article • European Journal of Inorganic Chemistry, March 2008, Wiley

    Dr ADORACION GOMEZ QUIROGA

  59. Isolation of an Intermediate in the Platination ofp-Nitroacetophenone 4-Methylthiosemicarbazone: Potential Application as an Antitumor Drug (Eur. J. Inorg. Chem. 8/2008)

    Article • European Journal of Inorganic Chemistry, March 2008, Wiley

    Dr ADORACION GOMEZ QUIROGA

  60. New trans-Platinum Drugs with Phosphines and Amines as Carrier Ligands Induce Apoptosis in Tumor Cells Resistant to Cisplatin

    Article • Journal of Medicinal Chemistry, April 2007, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  61. Trans platinum complexes design: One novel water soluble oxime derivative that contains aliphatic amines in trans configuration

    Article • Journal of Inorganic Biochemistry, January 2007, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  62. Structural Characterization, DNA Interactions, and Cytotoxicity of New Transplatin Analogues Containing One Aliphatic and One Planar Heterocyclic Amine Ligand

    Article • Journal of Medicinal Chemistry, March 2006, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  63. Novel Transplatinum(II) Complexes with [N2O2] Donor Sets. Cellular Pharmacology and Apoptosis Induction in Pam 212-ras Cells

    Article • Journal of Medicinal Chemistry, December 2005, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  64. Pyridine-Carboxylate Complexes of Platinum. Effect of N,O-Chelate Formation on Model Bifunctional DNA−DNA and DNA−Protein Interactions

    Article • Inorganic Chemistry, June 2005, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  65. Contribution to the SAR field of metallated and coordination complexes

    Article • Coordination Chemistry Reviews, January 2004, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  66. Preparation, characterization and cytotoxic activity of new compounds trans-[PtCl2NH3(3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3(4-(hydroxymethyl)-pyridine)]

    Article • Polyhedron, November 2003, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  67. Synthesis and Characterization of New Transplatinum Complexes Containing Phosphane Groups − Cytotoxic Studies in Cisplatin‐Resistant Cells

    Article • European Journal of Inorganic Chemistry, April 2003, Wiley

    Dr ADORACION GOMEZ QUIROGA

  68. Orientation‐ and Temperature‐Dependent Rotational Behavior of Imidazole Ligands (L) in β‐[Ru(azpy) 2 (L) 2 ](PF 6 ) 2 ...

    Article • European Journal of Inorganic Chemistry, February 2003, Wiley

    Dr ADORACION GOMEZ QUIROGA

  69. Determination of catalase activity in samples treated with [ZnCl2(isopropylamine)2]: a novel zinc complex that slows down the decay in activity of catalase extracts

    Article • Journal of the Chemical Society Dalton Transactions, April 2002, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA, Jorge García-Cañadas

  70. Synthesis, cytotoxic activities and proposed mode of binding of a series of bis{[(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl}alkylamines

    Article • European Journal of Medicinal Chemistry, April 2002, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  71. Cellular Uptake, DNA Binding and Apoptosis Induction of CytotoxicTrans‐[PtCl2(N,N‐dimethylamine)(Isopropylamine)] in A2780cisROvarian Tumor Cells

    Article • Metal-Based Drugs, January 2001, Wiley

    Dr ADORACION GOMEZ QUIROGA

  72. Synthesis and characterization of Pd(II) and Pt(II) complexes of -isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against -transformed cells

    Article • Journal of Inorganic Biochemistry, July 1999, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  73. A cycloplatinated compound of p-isopropylbenzaldehyde thiosemicarbazone and its chloro-bridged derivative induce apoptosis in cis-DDP resistant cells which overexpress the H-ras oncogene

    Article • Journal of Inorganic Biochemistry, April 1999, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  74. Synthesis, characterization and DNA modification induced by a novel Pt(IV)-bis(monoglutarate) complex which induces apoptosis in glioma cells

    Article • Chemico-Biological Interactions, January 1999, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  75. DNA binding and in vitro antileukemic activity of dimeric and tetrameric platinated complexes derived from p‐isopropylbenzaldehyde thiosemicarbazone

    Article • Applied Organometallic Chemistry, December 1998, Wiley

    Dr ADORACION GOMEZ QUIROGA

  76. Palladated and platinated complexes derived from phenylacetaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cells. Formation of DNA interstrand cross-links by these complexes

    Article • Journal of Inorganic Biochemistry, May 1998, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  77. Novel Tetranuclear Orthometalated Complexes of Pd(II) and Pt(II) Derived from p-Isopropylbenzaldehyde Thiosemicarbazone with Cytotoxic Activity in cis-DDP Resistant Tumor Cell Lines. Interaction of These Complexes with DNA

    Article • Journal of Medicinal Chemistry, March 1998, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA, Dr Pascual Roman

  78. Binuclear chloro-bridged palladated and platinated complexes derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxicity against cisplatin resistant tumor cell lines

    Article • Journal of Inorganic Biochemistry, March 1998, Elsevier

    Dr ADORACION GOMEZ QUIROGA