All Stories

  1. Identified the key target cell type for strategies to prevent atherosclerosis in progeria
  2. Aging and Vascular Disease: A Multidisciplinary Overview
  3. Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction
  4. Lamin A/C Ablation in Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction: Role in the Pathophysiology of LMNA-Related Dilated Cardiomyopathies
  5. Emerging roles of interferon-stimulated gene-15 in age-related telomere attrition, the DNA damage response, and cardiovascular disease
  6. Analysis of Monocyte Recruitment During Inflammation by Intravital Imaging
  7. Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry
  8. Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome
  9. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm: Impact on Inflammation, Oxidative Stress, and Vascular Remodeling
  10. Genomic instability in the naturally and prematurely aged myocardium
  11. Progression of Early Subclinical Atherosclerosis (PESA) Study
  12. Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome
  13. Triglycerides and Residual Atherosclerotic Risk
  14. Molecular and Cellular Mechanisms Driving Cardiovascular Disease in Hutchinson-Gilford Progeria Syndrome: Lessons Learned from Animal Models
  15. The progeria research foundation 10th international scientific workshop; researching possibilities, ExTENding lives – webinar version scientific summary
  16. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA
  17. Telomerase as a Therapeutic Target in Cardiovascular Disease
  18. Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson–Gilford progeria syndrome
  19. Premature Vascular Aging with Features of Plaque Vulnerability in an Atheroprone Mouse Model of Hutchinson–Gilford Progeria Syndrome with Ldlr Deficiency
  20. Machine Learning Improves Cardiovascular Risk Definition for Young, Asymptomatic Individuals
  21. Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis
  22. Identification of common cardiometabolic alterations and deregulated pathways in mouse and pig models of aging
  23. The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis
  24. Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
  25. miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis
  26. Short-Term Progression of Multiterritorial Subclinical Atherosclerosis
  27. Vascular Smooth Muscle Cell-Specific Progerin Expression Provokes Contractile Impairment in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that Is Ameliorated by Nitrite Treatment
  28. Biological Versus Chronological Aging
  29. Endothelial MT 1‐ MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis
  30. Lamin A/C deficiency in CD4+ T‐cells enhances regulatory T‐cells and prevents inflammatory bowel disease
  31. Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
  32. Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice
  33. Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome
  34. Vascular smooth muscle cell‐specific progerin expression in a mouse model of Hutchinson–Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite
  35. Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells
  36. Vascular smooth muscle cell loss underpins the accelerated atherosclerosis in Hutchinson-Gilford progeria syndrome
  37. Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM‐1
  38. Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification
  39. The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function
  40. Accelerated atherosclerosis in HGPS
  41. Electrocardiographic Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome
  42. Telomere Length as Cardiovascular Aging Biomarker
  43. Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome
  44. miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis
  45. MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
  46. Mecanismos de envejecimiento vascular: ¿Qué podemos aprender del síndrome de progeria de Hutchinson-Gilford?
  47. Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation
  48. Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
  49. Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major
  50. Current State of Basic and Translational Cardiovascular Research in Spain
  51. A-type lamins and cardiovascular disease in premature aging syndromes
  52. Novel phosphate-activated macrophages prevent ectopic calcification by increasing extracellular ATP and pyrophosphate
  53. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
  54. Proteomics Research in Cardiovascular Medicine and Biomarker Discovery
  55. Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations
  56. The CNIC
  57. Nestin+ cells direct inflammatory cell migration in atherosclerosis
  58. Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis
  59. Alternatively activated macrophages exhibit an anticalcifying activity dependent on extracellular ATP/pyrophosphate metabolism
  60. A Novel Systems-Biology Algorithm for the Analysis of Coordinated Protein Responses Using Quantitative Proteomics
  61. Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis
  62. ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression
  63. Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling
  64. Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK
  65. Impact of estrogens on atherosclerosis and bone in the apolipoprotein E–deficient mouse model
  66. Targeting γ-secretases protect against angiotensin II-induced cardiac hypertrophy
  67. ADAMTS7 in Cardiovascular Disease
  68. In Vitro Macrophage Phagocytosis Assay
  69. Isolation of Mouse Primary Aortic Endothelial Cells by Selection with Specific Antibodies
  70. Oil Red O and Hematoxylin and Eosin Staining for Quantification of Atherosclerosis Burden in Mouse Aorta and Aortic Root
  71. Sorting Nexin 6 Enhances Lamin A Synthesis and Incorporation into the Nuclear Envelope
  72. Vitamin D puts the brakes on angiotensin II-induced oxidative stress and vascular smooth muscle cell senescence
  73. Nuclear Envelope Lamin-A Couples Actin Dynamics with Immunological Synapse Architecture and T Cell Activation
  74. Polμ Deficiency Increases Resistance to Oxidative Damage and Delays Liver Aging
  75. High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice
  76. Age-dependent defective TGF-beta1 signaling in patients undergoing coronary artery bypass grafting
  77. Genetic Variants in CCNB1 Associated With Differential Gene Transcription and Risk of Coronary In-Stent Restenosis
  78. A major role for RCAN1 in atherosclerosis progression
  79. PI3K p110γ Deletion Attenuates Murine Atherosclerosis by Reducing Macrophage Proliferation but Not Polarization or Apoptosis in Lesions
  80. Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis
  81. Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment
  82. Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells
  83. Embryological-Origin-Dependent Differences in Homeobox Expression in Adult Aorta: Role in Regional Phenotypic Variability and Regulation of NF- B Activity
  84. Inactivation of Nuclear Factor-Y Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation
  85. Role of c-MYC in tumor-associated macrophages and cancer progression
  86. Increased dosage ofInk4/Arfprotects against glucose intolerance and insulin resistance associated with aging
  87. Macrophage proliferation and apoptosis in atherosclerosis
  88. In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities
  89. Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis
  90. Limus Is Not Limus—A Proposal to Adjust Terminology in the Context of Drug-eluting Stents
  91. Increased gene dosage of the Ink4/Arf locus does not attenuate atherosclerosis development in hypercholesterolaemic mice
  92. The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells
  93. Synthesis, transport and incorporation into the nuclear envelope of A-type lamins and inner nuclear membrane proteins
  94. A glimpse on the phenomenon of macrophage polarization during atherosclerosis
  95. Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging
  96. Deficient p27 Phosphorylation at Serine 10 Increases Macrophage Foam Cell Formation and Aggravates Atherosclerosis Through a Proliferation-Independent Mechanism
  97. Insulin Receptor Substrate-1 Expression Is Increased in Circulating Leukocytes of Patients with Acute Coronary Syndrome
  98. A-type lamins and Hutchinson-Gilford progeria syndrome: pathogenesis and therapy
  99. ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma–lamin A complexes
  100. A role for miR-33 in p53 regulation: New perspectives for hematopoietic stem cell research
  101. Tumor suppressor p27Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6
  102. p19ARFDeficiency Reduces Macrophage and Vascular Smooth Muscle Cell Apoptosis and Aggravates Atherosclerosis
  103. Control of cell proliferation in atherosclerosis: insights from animal models and human studies
  104. Molecular Mechanisms of Atherosclerosis in Metabolic Syndrome
  105. Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope
  106. Atherosclerosis development in apolipoprotein E-null mice deficient for CD69
  107. Complement regulation in murine and human hypercholesterolemia and role in the control of macrophage and smooth muscle cell proliferation
  108. Telomere dysfunction in hypertension
  109. Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis
  110. Classic and novel roles of p53: prospects for anticancer therapy
  111. Role of the CDKN1A/p21, CDKN1C/p57, and CDKN2A/p16 Genes in the Risk of Atherosclerosis and Myocardial Infarction
  112. Murine models to investigate the influence of diabetic metabolism on the development of atherosclerosis and restenosis
  113. Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice
  114. Telomere Biology and Cardiovascular Disease
  115. Potential role of proliferation signal inhibitors on atherosclerosis in renal transplant patients
  116. Cytostatic gene therapy for occlusive vascular disease
  117. A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C
  118. Atheroma development in apolipoprotein E-null mice is not affected by partial inactivation of PTEN
  119. Atheroma development in apolipoprotein E‐null mice is not regulated by phosphorylation of p27Kip1 on threonine 187
  120. Aging, telomeres, and atherosclerosis
  121. Transcriptional profiling of early onset diet-induced atherosclerosis in apolipoprotein E-deficient mice
  122. Unexpected Proatherogenic Properties of p21
  123. Control of vascular cell proliferation and migration by cyclin-dependent kinase signalling: new perspectives and therapeutic potential
  124. Atherogenic role of the type EIIIA fibronectin domain
  125. Role of E2F and ERK1/2 in STI571-mediated smooth muscle cell growth arrest and cyclin A transcriptional repression
  126. Telomeres and Cardiovascular Disease
  127. Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27Kip1-independent pathway
  128. Selective inactivation of p27Kip1 in hematopoietic progenitor cells increases neointimal macrophage proliferation and accelerates atherosclerosis
  129. Short telomeres protect from diet‐induced atherosclerosis in apolipoprotein E‐null mice
  130. Optic Nerve Alterations in Apolipoprotein E Deficient Mice
  131. Cyclin-dependent protein kinases as therapeutic targets in cardiovascular disease
  132. Coordinate Control of Proliferation and Migration by the p27 Kip1 /Cyclin-Dependent Kinase/Retinoblastoma Pathway in Vascular Smooth Muscle Cells and Fibroblasts
  133. Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
  134. Antiproliferative Strategies for the Treatment of Vascular Proliferative Disease
  135. Inhibiting Cyclin-Dependent Kinase / Cyclin Activity for the Treatment of Cancer and Cardiovascular Disease
  136. Distinct Regulation of Mitogen-activated Protein Kinases and p27Kip1 in Smooth Muscle Cells from Different Vascular Beds
  137. Increased early atherogenesis in young versus old hypercholesterolemic rabbits by a mechanism independent of arterial cell proliferation
  138. The growth suppressor p27Kip1 protects against diet-induced atherosclerosis
  139. Overexpression of p27Kip1by doxycycline‐regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis
  140. Inhibition of the cyclin D1/E2F pathway by PCA‐4230, a potent repressor of cellular proliferation
  141. Role of Sp1 in the Induction of p27 Gene Expression in Vascular Smooth Muscle Cells In Vitro and After Balloon Angioplasty
  142. Inhibition of Cellular Proliferation by Drug Targeting of Cyclin-Dependent Kinases
  143. Age-dependent increase in c-fos activity and cyclin A expression in vascular smooth muscle cells A potential link between aging, smooth muscle cell proliferation and atherosclerosis
  144. Control of vascular smooth muscle cell growth by cyclin-dependent kinase inhibitory proteins and its implication in cardiovascular disease
  145. Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21Cip1/WAF1
  146. Antibody Blockade of Thrombospondin Accelerates Reendothelialization and Reduces Neointima Formation in Balloon-Injured Rat Carotid Artery
  147. Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation
  148. Control of vascular smooth muscle cell growth and its implication in atherosclerosis and restenosis (review).
  149. Nitric Oxide–Induced Downregulation of Cdk2 Activity and Cyclin A Gene Transcription in Vascular Smooth Muscle Cells
  150. Role of c-fos and E2F in the induction of cyclin A transcription and vascular smooth muscle cell proliferation.
  151. Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery.
  152. Embryonic Expression of the Gax Homeodomain Protein in Cardiac, Smooth, and Skeletal Muscle
  153. Myofibril-bound muscle phosphofructokinase is less sensitive to inhibition by ATP than the free enzyme, but retains its sensitivity to stimulation by bisphosphorylated hexoses
  154. Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis.
  155. Determination of the Consensus Binding Site for MEF2 Expressed in Muscle and Brain Reveals Tissue-specific Sequence Constraints
  156. Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2.
  157. MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation.
  158. A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins.
  159. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.
  160. GLUCOSE 1, 6-BISPHOSPHATE AND FRUCTOSE 2, 6-BISPHOSPHATE IN MUSCLE FROM HEALTHY HUMANS AND CHRONIC ALCOHOLIC PATIENTS
  161. Identification of guanine and adenine nucleotides as activators of glucose-1,6-bisphosphatase activity from rat skeletal muscle
  162. Regulation of muscle phosphofructokinase by physiological concentrations of bisphosphorylated hexoses: Effect of alkalinization
  163. Effect of denervation on the distribution and developmental transition of phosphoglycerate mutase and creatine phosphokinase isozymes in rat muscles of different fiber-type composition
  164. Distribution and developmental transition of phosphoglycerate mutase and creatine phosphokinase isozymes in rat muscles of different fiber-type composition
  165. Allosteric inhibition of Dictyostelium discoideum fructose‐1,6‐bisphosphatase by fructose 2,6‐bisphosphate
  166. Activation of muscle phosphofructokinase by α-glucose 1,6-bisphosphate and fructose 2,6-bisphosphate is differently affected by other allosteric effectors and by pH