All Stories

  1. Perspective on CETSA Literature: Toward More Quantitative Data Interpretation

    Article • SLAS DISCOVERY, October 2019, SAGE Publications

    Dr Thomas Lundbäck

  2. Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay

    Article • Biochemistry, November 2018, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  3. A drug screening assay on cancer cells chronically adapted to acidosis

    Article • Cancer Cell International, September 2018, Springer Science + Business Media

    Dr Thomas Lundbäck

  4. Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

    Article • ACS Chemical Biology, September 2018, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  5. Identification of inhibitors of Tartrate-resistant acid phosphatase (TRAP/ACP5 ) activity by small-molecule screening

    Article • Chemical Biology & Drug Design, March 2018, Wiley

    Dr Thomas Lundbäck

  6. The first study of physical target engagement in cells with single cell resolution

    Article • ACS Chemical Biology, February 2018, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  7. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

    Article • Nature Communications, January 2018, Springer Science + Business Media

    Dr Thomas Lundbäck, Dr Roni Wright

  8. Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems

    Article • Bioorganic & Medicinal Chemistry Letters, August 2017, Elsevier

    Dr Thomas Lundbäck

  9. Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

    Article • Proceedings of the National Academy of Sciences, July 2017, Proceedings of the National Academy of Sciences

    Dr Thomas Lundbäck

  10. Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

    Article • Journal of Medicinal Chemistry, May 2017, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  11. dUTPase inhibition augments replication defects of 5-Fluorouracil

    Article • Oncotarget, March 2017, Impact Journals, LLC

    Dr Thomas Lundbäck

  12. Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1

    Article • Journal of Medicinal Chemistry, February 2017, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  13. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

    Article • Nature Medicine, January 2017, Springer Science + Business Media

    Dr Thomas Lundbäck

  14. Cellular thermal shift assays in microplate format

    Article • SLAS DISCOVERY, December 2016, SAGE Publications

    Dr Thomas Lundbäck

  15. Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

    Article • ACS Chemical Neuroscience, August 2016, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  16. Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis

    Article • Journal of Medicinal Chemistry, July 2016, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  17. Interview with Thomas Lundbäck, PhD

    Article • Assay and Drug Development Technologies, May 2016, Mary Ann Liebert Inc

    Dr Thomas Lundbäck

  18. Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

    Article • Assay and Drug Development Technologies, April 2016, Mary Ann Liebert Inc

    Dr Thomas Lundbäck

  19. CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

    Article • Nature Communications, March 2016, Nature

    Dr Thomas Lundbäck

  20. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

    Article • Journal of Medicinal Chemistry, January 2016, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  21. Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density

    Article • Molecular Pharmacology, January 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Thomas Lundbäck

  22. Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

    Article • Journal of Chemical Information and Computer Sciences, August 2015, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  23. Abstract 5509: A drug-screening model to identify compounds active in cells under metabolic stress

    Article • Cancer Research, August 2015, American Association for Cancer Research (AACR)

    Dr Thomas Lundbäck

  24. Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

    Article • PLoS ONE, June 2015, PLOS

    Dr Thomas Lundbäck

  25. CETSA: a target engagement assay with potential to transform drug discovery

    Article • Future Medicinal Chemistry, June 2015, Future Science

    Dr Thomas Lundbäck

  26. Revealing the secrets of intractable cellular functions: All-in-one-well methods for studying protein interaction and secretion

    Article • Science, April 2015, American Association for the Advancement of Science

    Dr Thomas Lundbäck

  27. Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

    Article • ChemistryOpen, November 2014, Wiley

    Dr Thomas Lundbäck

  28. Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors

    Article • Organic Process Research & Development, October 2014, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  29. Controversies inASSAY and Drug Development Technologies: A Focus on Assessing Irreproducibility

    Article • Assay and Drug Development Technologies, October 2014, Mary Ann Liebert Inc

    Dr Thomas Lundbäck

  30. The cellular thermal shift assay for evaluating drug target interactions in cells

    Article • Nature Protocols, August 2014, Nature

    Dr Thomas Lundbäck

  31. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

    Article • Nature, April 2014, Springer Science + Business Media

    Dr Matthieu Desroses, Dr Thomas Lundbäck

  32. Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation

    Article • Cancer Immunology Immunotherapy, March 2014, Springer Science + Business Media

    Dr Thomas Lundbäck

  33. A drug-screening model to identify compounds active in cells under metabolic stress

    Article • Frontiers in Pharmacology, January 2014, Frontiers

    Dr Thomas Lundbäck

  34. Structure–Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

    Article • Journal of Medicinal Chemistry, December 2013, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  35. In Vitro and In Vivo Activities of 2-Aminopyrazines and 2-Aminopyridines in Experimental Models of Human African Trypanosomiasis

    Article • Antimicrobial Agents and Chemotherapy, December 2012, ASM Journals

    Dr Thomas Lundbäck

  36. A novel assay of cellular stearoyl-CoA desaturase activity of primary rat hepatocytes by HPLC

    Article • Journal of Chromatography B, September 2010, Elsevier

    Dr Thomas Lundbäck

  37. N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, March 2009, Elsevier

    Dr Thomas Lundbäck

  38. Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target

    Article • Bioorganic & Medicinal Chemistry Letters, September 2004, Elsevier

    Dr Thomas Lundbäck

  39. Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, September 2004, Elsevier

    Dr Thomas Lundbäck

  40. On the Nature of Solvent Effects on Redox Properties

    Article • The Journal of Physical Chemistry A, May 2004, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  41. Structure-Based Screening As Applied to Human FABP4:  A Highly Efficient Alternative to HTS for Hit Generation

    Article • Journal of the American Chemical Society, October 2002, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  42. Sequence-Specific DNA Binding by the Glucocorticoid Receptor DNA-Binding Domain Is Linked to a Salt-Dependent Histidine Protonation†

    Article • Biochemistry, August 2000, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  43. Characterization of Sequence-Specific DNA Binding by the Transcription Factor Oct-1†

    Article • Biochemistry, June 2000, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  44. Oligomerization of the chromatin-structuring protein H-NS

    Article • Molecular Microbiology, May 2000, Wiley

    Dr Thomas Lundbäck

  45. Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding

    Article • Journal of Molecular Biology, May 1999, Elsevier

    Dr Thomas Lundbäck

  46. Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricus

    Article • Journal of Molecular Biology, March 1998, Elsevier

    Dr Thomas Lundbäck

  47. Thermodynamics of sequence-specific protein-DNA interactions

    Article • Biophysical Chemistry, November 1996, Elsevier

    Dr Thomas Lundbäck

  48. Sequence-specific DNA-binding dominated by dehydration.

    Article • Proceedings of the National Academy of Sciences, May 1996, Proceedings of the National Academy of Sciences

    Dr Thomas Lundbäck

  49. Salt Dependence of the Free Energy, Enthalpy, and Entropy of Nonsequence Specific DNA Binding

    Article • The Journal of Physical Chemistry, January 1996, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  50. Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus

    Article • Nature Structural Biology, November 1994, Nature

    Dr Thomas Lundbäck

  51. Thermodynamics of sequence-specific glucocorticoid receptor-DNA interactions

    Article • Biochemistry, May 1994, American Chemical Society (ACS)

    Dr Thomas Lundbäck

  52. Thermodynamics of the glucocorticoid receptor-DNA interaction: Binding of wild-type GR DBD to different response elements

    Article • Biochemistry, May 1993, American Chemical Society (ACS)

    Dr Thomas Lundbäck