All Stories

  1. Structural Insights into the Iodothyronine Deiodinase 2 Catalytic Core and Deiodinase Catalysis and Dimerization

    Article • Biomolecules, October 2024, MDPI AG

    Josef Köhrle

  2. Identifying novel DIO1 inhibitors to modulate hepatic T3 availability in context of non-alcoholic fatty liver disease

    Article • Endocrine Abstracts, August 2024, Bioscientifica

    Josef Köhrle

  3. Identification of Human TRIAC Transmembrane Transporters

    Article • Thyroid, July 2024, Mary Ann Liebert Inc

    Josef Köhrle

  4. Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts

    Article • Communications Biology, May 2024, Springer Science + Business Media

    Josef Köhrle

  5. Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) transporter facilitated thyroid hormone transport using a modified nonradioactive assay

    Article • Toxicology in Vitro, April 2024, Elsevier

    Josef Köhrle

  6. Low thyroxine serves as an upstream regulator of ecophysiological adaptations in Ansell’s mole-rats

    Article • Frontiers in Endocrinology, March 2024, Frontiers

    Josef Köhrle

  7. Endocrine disrupting chemicals are a threat to hormone health: a commentary on behalf of the ESE

    Article • Nature Reviews Endocrinology, February 2024, Springer Science + Business Media

    Josef Köhrle

  8. Response to Fitzgerald et al. re: “Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status”

    Article • Thyroid, February 2024, Mary Ann Liebert Inc

    Josef Köhrle

  9. Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults

    Article • European Journal of Epidemiology, January 2024, Springer Science + Business Media

    Josef Köhrle

  10. Endocrine disruptors and thyroid function

    Article • January 2024, Elsevier

    Josef Köhrle

  11. Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status

    Article • Thyroid, September 2023, Mary Ann Liebert Inc

    Josef Köhrle

  12. Clinical Interpretation of Thyroid Tests: Considerations for Reference Intervals

    Article • Thyroid, April 2023, Mary Ann Liebert Inc

    Josef Köhrle

  13. Hepatic Energy Metabolism under the Local Control of the Thyroid Hormone System

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Josef Köhrle

  14. Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle

    Article • Scientific Reports, February 2023, Springer Science + Business Media

    Josef Köhrle

  15. Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Josef Köhrle

  16. The ETA–ESE statement on the European Chemicals Agency opinion on iodine as an endocrine disruptor

    Article • European Thyroid Journal, February 2023, Bioscientifica

    Josef Köhrle

  17. Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice

    Article • Redox Biology, November 2022, Elsevier

    Professor Lutz Schomburg, Josef Köhrle

  18. Deiodinases control local cellular and systemic thyroid hormone availability

    Article • Free Radical Biology and Medicine, November 2022, Elsevier

    Josef Köhrle

  19. Human cerebral organoids as in vitro platform to assess thyroid hormone system disrupting chemicals

    Article • Endocrine Abstracts, September 2022, Bioscientifica

    Josef Köhrle

  20. 3,5-T2-an Endogenous Thyroid Hormone Metabolite as Promising Lead Substance in Anti-Steatotic Drug Development?

    Article • Metabolites, June 2022, MDPI AG

    Josef Köhrle

  21. Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data

    Article • Metabolites, May 2022, MDPI AG

    Josef Köhrle

  22. 3,5-T2 - An Endogenous Thyroid Hormone Metabolite As Promising Lead Substance in Anti-Steatotic Drug Development?

    Article • May 2022, MDPI AG

    Josef Köhrle

  23. Great impact in low quantities - thyroid hormones, trace elements and endocrine disruptors

    Article • Endocrine Abstracts, May 2022, Bioscientifica

    Josef Köhrle

  24. Tentative Application of a Streamlined Protocol to Determine Organ-Specific Regulations of Deiodinase 1 and Dehalogenase Activities as Readouts of the Hypothalamus-Pituitary-Thyroid-Periphery-Axis

    Article • Frontiers in Toxicology, March 2022, Frontiers

    Josef Köhrle

  25. 100 YEARS OF VITAMIN D: Light and health: a century after the therapeutic use of UV light and vitamin D, hormones advanced medical care

    Article • Endocrine Connections, January 2022, Bioscientifica

    Josef Köhrle

  26. Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring

    Article • Toxicology Letters, January 2022, Elsevier

    Josef Köhrle

  27. Age-dependent response to T4 overtreatment and recovery on systemic and organ level

    Article • Journal of Molecular Endocrinology, November 2021, Bioscientifica

    Josef Köhrle

  28. Thyroid hormone system disrupting chemicals

    Article • Best Practice & Research Clinical Endocrinology & Metabolism, September 2021, Elsevier

    Josef Köhrle

  29. Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase

    Article • Environmental Pollution, August 2021, Elsevier

    Josef Köhrle

  30. Comparative Analysis of the Effects of Long-Term 3,5-diiodothyronine Treatment on the Murine Hepatic Proteome and Transcriptome Under Conditions of Normal Diet and High-Fat Diet

    Article • Thyroid, July 2021, Mary Ann Liebert Inc

    Josef Köhrle

  31. Identification of iodothyronine deiodinase 2 inhibitors among FDA-approved drug library using high throughput screening

    Article • Endocrine Abstracts, May 2021, Bioscientifica

    Josef Köhrle

  32. Goodbye and farewell to Endocrine Connections!

    Article • Endocrine Connections, March 2021, Bioscientifica

    Josef Köhrle

  33. Obesity and Pregnancy. Guideline of the German Society of Gynecology and Obstetrics (S3-Level, AWMF Registry No. 015-081, June 2019)

    Article • Geburtshilfe und Frauenheilkunde, March 2021, Thieme Publishing Group

    Josef Köhrle

  34. Selenium in Endocrinology—Selenoprotein-Related Diseases, Population Studies, and Epidemiological Evidence

    Article • Endocrinology, December 2020, Endocrine Society

    Josef Köhrle

  35. Adversity Considerations for Thyroid Follicular Cell Hypertrophy and Hyperplasia in Nonclinical Toxicity Studies: Results From the 6th ESTP International Expert Workshop

    Article • Toxicologic Pathology, December 2020, SAGE Publications

    Josef Köhrle

  36. Disruption of BMP Signaling Prevents Hyperthyroidism‐Induced Bone Loss in Male Mice

    Article • Journal of Bone and Mineral Research, June 2020, Wiley

    Josef Köhrle

  37. CD5L Constitutes a Novel Biomarker for Integrated Hepatic Thyroid Hormone Action

    Article • Thyroid, June 2020, Mary Ann Liebert Inc

    Professor Lutz Schomburg, Josef Köhrle

  38. Mass Spectrometry-Based Determination of Thyroid Hormones and Their Metabolites in Endocrine Diagnostics and Biomedical Research – Implications for Human Serum Diagnostics

    Article • Experimental and Clinical Endocrinology & Diabetes, June 2020, Thieme Publishing Group

    Josef Köhrle

  39. Endocrine, Metabolic and Pharmacological Effects of Thyronamines (TAM), Thyroacetic Acids (TA) and Thyroid Hormone Metabolites (THM) – Evidence from in vitro, Cellular, Experimental Animal and Human ...

    Article • Experimental and Clinical Endocrinology & Diabetes, May 2020, Thieme Publishing Group

    Josef Köhrle

  40. Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project

    Article • International Journal of Molecular Sciences, April 2020, MDPI AG

    Josef Köhrle

  41. Lack of the Thyroid Hormone Transporter Mct8 in Osteoblast and Osteoclast Progenitors Increases Trabecular Bone in Male Mice

    Article • Thyroid, February 2020, Mary Ann Liebert Inc

    Josef Köhrle

  42. 3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action

    Article • Frontiers in Endocrinology, January 2020, Frontiers

    Josef Köhrle

  43. A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans

    Article • Thyroid, December 2019, Mary Ann Liebert Inc

    Josef Köhrle

  44. A combined LC-MS/MS and LC-MS3 multi-method for the quantification of iodothyronines in human blood serum

    Article • Analytical and Bioanalytical Chemistry, June 2019, Springer Science + Business Media

    Josef Köhrle

  45. The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats

    Article • The Journal of Steroid Biochemistry and Molecular Biology, June 2019, Elsevier

    Josef Köhrle

  46. Aging Alters Phenotypic Traits of Thyroid Dysfunction in Male Mice With Divergent Effects on Complex Systems but Preserved Thyroid Hormone Action in Target Organs

    Article • The Journals of Gerontology Series A, February 2019, Oxford University Press (OUP)

    Josef Köhrle

  47. The Role of Dickkopf-1 in Thyroid Hormone–Induced Changes of Bone Remodeling in Male Mice

    Article • Endocrinology, January 2019, Endocrine Society

    Josef Köhrle

  48. 3-Iodothyronamine—A Thyroid Hormone Metabolite With Distinct Target Profiles and Mode of Action

    Article • Endocrine Reviews, January 2019, Endocrine Society

    Josef Köhrle

  49. In Memoriam: Lewis E. Braverman (1929–2019)

    Article • European Thyroid Journal, January 2019, Bioscientifica

    Josef Köhrle

  50. The Colorful Diversity of Thyroid Hormone Metabolites

    Article • European Thyroid Journal, January 2019, Bioscientifica

    Josef Köhrle

  51. Endocrine Disruptors and Thyroid Function

    Article • January 2019, Elsevier

    Josef Köhrle

  52. The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women

    Article • Frontiers in Endocrinology, November 2018, Frontiers

    Josef Köhrle

  53. Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes

    Article • Frontiers in Endocrinology, November 2018, Frontiers

    Josef Köhrle

  54. TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells

    Article • Frontiers in Pharmacology, November 2018, Frontiers

    Josef Köhrle

  55. Association Between 3-Iodothyronamine (T1am) Concentrations and Left Ventricular Function in Chronic Heart Failure

    Article • The Journal of Clinical Endocrinology & Metabolism, October 2018, Endocrine Society

    Josef Köhrle

  56. Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation

    Article • Archives of Toxicology, August 2018, Springer Science + Business Media

    Dr Dirk W Lachenmeier, Josef Köhrle

  57. Proteome analysis of 3,5-T2-treated primary mouse hepatocytes

    Article • Endocrine Abstracts, May 2018, Bioscientifica

    Josef Köhrle

  58. Genistein Increase Thyroid Hormone and 7 alpha-hydroxycholesterol concentrations in the liver of middle-aged male rats

    Article • Endocrine Abstracts, May 2018, Bioscientifica

    Josef Köhrle

  59. A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans

    Article • Endocrine Abstracts, May 2018, Bioscientifica

    Josef Köhrle

  60. Micronutrient status assessment in humans: Current methods of analysis and future trends

    Article • TrAC Trends in Analytical Chemistry, May 2018, Elsevier

    Josef Köhrle

  61. Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression

    Article • Frontiers in Pharmacology, March 2018, Frontiers

    Josef Köhrle

  62. Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets

    Article • January 2018, Springer Science + Business Media

    Josef Köhrle

  63. Relaxin-2 connecting peptide (pro-RLX2) levels in second trimester serum samples to predict preeclampsia

    Article • Pregnancy Hypertension, January 2018, Elsevier

    Josef Köhrle

  64. 3-Iodothyronamine reduces insulin secretion in vitro via a mitochondrial mechanism

    Article • Molecular and Cellular Endocrinology, January 2018, Elsevier

    Josef Köhrle

  65. Thyroid Hormone Metabolism

    Article • January 2018, Elsevier

    Josef Köhrle

  66. Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system

    Article • PLOS One, December 2017, PLOS

    Josef Köhrle

  67. Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

    Article • Proceedings of the National Academy of Sciences, December 2017, Proceedings of the National Academy of Sciences

    Josef Köhrle

  68. BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARγ and GLUT4 upregulation

    Article • Scientific Reports, December 2017, Springer Science + Business Media

    Josef Köhrle

  69. In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice

    Article • European Thyroid Journal, December 2017, Bioscientifica

    Professor Lutz Schomburg, Josef Köhrle

  70. Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice

    Article • Biology of Sex Differences, December 2017, Springer Science + Business Media

    Josef Köhrle

  71. Editorial: Get inspired - Lessons learned from evolution of thyroid hormone signaling in developmental processes

    Article • Molecular and Cellular Endocrinology, December 2017, Elsevier

    Josef Köhrle

  72. Avoiding the pitfalls when quantifying thyroid hormones and their metabolites using mass spectrometric methods: The role of quality assurance

    Article • Molecular and Cellular Endocrinology, December 2017, Elsevier

    Josef Köhrle

  73. A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes

    Article • PLOS One, August 2017, PLOS

    Josef Köhrle

  74. Quantification of Relaxin-2 Connecting Peptide (Pro-RLX2) in Human Blood Samples

    Article • The Journal of Applied Laboratory Medicine, August 2017, AACC

    Josef Köhrle

  75. Sclerostin Blockade and Zoledronic Acid Improve Bone Mass and Strength in Male Mice With Exogenous Hyperthyroidism

    Article • Endocrinology, July 2017, Endocrine Society

    Josef Köhrle

  76. Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P

    Article • Scientific Reports, June 2017, Springer Science + Business Media

    Professor Lutz Schomburg, Josef Köhrle

  77. Treatment with thyroid hormone metabolite 3,5-T2 alters cholesterol and sex steroid metabolism in mouse liver

    Article • Endocrine Abstracts, May 2017, Bioscientifica

    Josef Köhrle

  78. Igniting stage two in Endocrine Connections

    Article • Endocrine Connections, May 2017, Bioscientifica

    Josef Köhrle

  79. Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P

    Article • Redox Biology, April 2017, Elsevier

    Professor Lutz Schomburg, Josef Köhrle

  80. Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids

    Article • Molecular and Cellular Endocrinology, March 2017, Elsevier

    Josef Köhrle

  81. 3-Iodothyronamine Decreases Expression of Genes Involved in Iodide Metabolism in Mouse Thyroids and Inhibits Iodide Uptake in PCCL3 Thyrocytes

    Article • Thyroid, January 2017, Mary Ann Liebert Inc

    Josef Köhrle

  82. Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice

    Article • Scientific Reports, December 2016, Springer Science + Business Media

    Josef Köhrle

  83. A Nonradioactive DEHAL Assay for Testing Substrates, Inhibitors, and Monitoring Endogenous Activity

    Article • Endocrinology, December 2016, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  84. Circulating 3-T1AM and 3,5-T2 in Critically Ill Patients: A Cross-Sectional Observational Study

    Article • Thyroid, December 2016, Mary Ann Liebert Inc

    Josef Köhrle

  85. Thyronamines and Derivatives: Physiological Relevance, Pharmacological Actions, and Future Research Directions

    Article • Thyroid, December 2016, Mary Ann Liebert Inc

    Josef Köhrle

  86. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

    Article • Cell, October 2016, Elsevier

    Josef Köhrle

  87. Selenoprotein Gene Nomenclature

    Article • Journal of Biological Chemistry, September 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Elias Arner, Professor Lutz Schomburg, Josef Köhrle

  88. Factors impacting the aminoglycoside-induced UGA stop codon readthrough in selenoprotein translation

    Article • Journal of Trace Elements in Medicine and Biology, September 2016, Elsevier

    Professor Lutz Schomburg, Josef Köhrle

  89. Sex-specific phenotypes of hyperthyroidism and hypothyroidism in mice

    Article • Biology of Sex Differences, August 2016, Springer Science + Business Media

    Josef Köhrle

  90. Efficacy of protocols for induction of chronic hyperthyroidism in male and female mice

    Article • Endocrine, July 2016, Springer Science + Business Media

    Josef Köhrle

  91. High Variability of Insulin Sensitivity in Closely Related Obese Mouse Inbred Strains

    Article • Experimental and Clinical Endocrinology & Diabetes, July 2016, Thieme Publishing Group

    Josef Köhrle

  92. Minireview: Insights Into the Structural and Molecular Consequences of the TSH-β Mutation C105Vfs114X

    Article • Molecular Endocrinology, July 2016, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  93. Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10*

    Article • Molecular Endocrinology, July 2016, Endocrine Society

    Josef Köhrle

  94. Thyroid hormone and its metabolites in relation to quality of life in patients treated for differentiated thyroid cancer

    Article • Clinical Endocrinology, June 2016, Wiley

    Josef Köhrle

  95. 3-T1AM signaling in the rat thyrocyte cell line PCCL3

    Article • Endocrine Abstracts, May 2016, Bioscientifica

    Josef Köhrle

  96. Circulating 3-T1AM and 3,5-T2 in critically ill patients: a cross-sectional observational study

    Article • Endocrine Abstracts, May 2016, Bioscientifica

    Josef Köhrle

  97. Faculty Opinions recommendation of Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis.

    Article • April 2016, F1000Research

    Josef Köhrle

  98. Impact of Endocrine Disruptor Policies and Regulations

    Article • April 2016, Taylor & Francis

    Josef Köhrle

  99. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8

    Article • Endocrinology, April 2016, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  100. Exposure to Thyroid-Disrupting Chemicals: A Transatlantic Call for Action

    Article • Thyroid, April 2016, Mary Ann Liebert Inc

    Josef Köhrle

  101. High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

    Article • European Radiology, March 2016, Springer Science + Business Media

    Josef Köhrle

  102. 3-Iodothyronamine increases transient receptor potential melastatin channel 8 (TRPM8) activity in immortalized human corneal epithelial cells

    Article • Cellular Signalling, March 2016, Elsevier

    Josef Köhrle

  103. A bioactive thyroid hormone metabolite alters hepatic metabolism

    Article • Journal of Molecular Endocrinology, February 2016, Bioscientifica

    Josef Köhrle

  104. Differential Modulation of Adrenergic Receptor Signaling by Octopamine, Tyramine, Phenylethylamine, and 3-Iodothyronamine

    Article • January 2016, Elsevier

    Josef Köhrle

  105. Selenium and Endocrine Tissues

    Article • January 2016, Springer Science + Business Media

    Josef Köhrle

  106. Selenoprotein P and Selenium Distribution in Mammals

    Article • January 2016, Springer Science + Business Media

    Josef Köhrle

  107. Testosterone and estradiol treatments differently affect pituitary-thyroid axis and liver deiodinase 1 activity in orchidectomized middle-aged rats

    Article • Experimental Gerontology, December 2015, Elsevier

    Josef Köhrle

  108. Biosynthesis of 3-Iodothyronamine From T4in Murine Intestinal Tissue

    Article • Endocrinology, November 2015, Endocrine Society

    Josef Köhrle

  109. Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1

    Article • Endocrinology, October 2015, Endocrine Society

    Josef Köhrle

  110. Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters

    Article • Thyroid, October 2015, Mary Ann Liebert Inc

    Professor Lutz Schomburg, Josef Köhrle

  111. Selenium and the thyroid

    Article • Current Opinion in Endocrinology Diabetes and Obesity, October 2015, Wolters Kluwer Health

    Josef Köhrle

  112. An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

    Article • Thyroid, August 2015, Mary Ann Liebert Inc

    Professor Lutz Schomburg, Josef Köhrle

  113. The Effects of Thyroid Hormones on Gene Expression of Acyl-Coenzyme A Thioesterases in Adipose Tissue and Liver of Mice

    Article • European Thyroid Journal, July 2015, Bioscientifica

    Josef Köhrle

  114. A Nonradioactive Uptake Assay for Rapid Analysis of Thyroid Hormone Transporter Function

    Article • Endocrinology, July 2015, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  115. Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia

    Article • European Thyroid Journal, June 2015, Bioscientifica

    Josef Köhrle

  116. 3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling

    Article • Journal of Molecular Endocrinology, June 2015, Bioscientifica

    Josef Köhrle

  117. Structural Insights Into Thyroid Hormone Transport Mechanisms of the L-Type Amino Acid Transporter 2

    Article • Molecular Endocrinology, June 2015, Endocrine Society

    Josef Köhrle

  118. 3,5-T2 might play a crucial role in the rodent heart

    Article • Endocrine Abstracts, May 2015, Bioscientifica

    Josef Köhrle

  119. Abnormal circulating thyroid hormone levels in MCT8-deficiency are not caused by increased hepatic conversion through type i-deiodinase

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  120. Effects of repeated 3-T1AM treatment on thyrocytes in mice

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  121. Effects of the thyroid hormone metabolite 3,5-T2 on murine heart tissue and the cardiomyocyte cell line H9C2

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  122. Establishment of a non-isotopic activity assay for thyroid hormone transporters

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  123. Influence of thyroid hormones on brown adipose tissue activity and browning of white adipose tissues in mice

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  124. New G protein coupled receptor targets for 3-iodotyronamine

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  125. Phenotypic and molecular characterization of age-dependent thyroid hormone action in mice

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  126. Quantitative analysis of thyroid hormone metabolites in cell culture samples using LC-MS/MS

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  127. Towards the intestinal biosynthesis of 3-iodothyronamine

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2015, Thieme Publishing Group

    Josef Köhrle

  128. Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace Amine-Associated Receptor 5

    Article • PLOS One, February 2015, PLOS

    Josef Köhrle

  129. Establishment and characterization of a new ELISA for selenoprotein P

    Article • Perspectives in Science, February 2015, Elsevier

    Josef Köhrle

  130. Lokalisation und Verteilung von Selenoprotein P im humanen Gehirn

    Article • Perspectives in Science, February 2015, Elsevier

    Josef Köhrle

  131. Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells

    Article • Cellular Signalling, February 2015, Elsevier

    Josef Köhrle

  132. Translating Pharmacological Findings from Hypothyroid Rodents to Euthyroid Humans: Is There a Functional Role of Endogenous 3,5-T2?

    Article • Thyroid, February 2015, Mary Ann Liebert Inc

    Josef Köhrle

  133. Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling

    Article • European Thyroid Journal, January 2015, Karger Publishers

    PD Dr. med. Johannes W Dietrich, Josef Köhrle

  134. 3,5-Diiodo-L-Thyronine (3,5-T2) Exerts Thyromimetic Effects on Hypothalamus-Pituitary-Thyroid Axis, Body Composition, and Energy Metabolism in Male Diet-Induced Obese Mice

    Article • Endocrinology, January 2015, Endocrine Society

    Josef Köhrle

  135. Differences in Mouse Hepatic Thyroid Hormone Transporter Expression with Age and Hyperthyroidism

    Article • European Thyroid Journal, January 2015, Bioscientifica

    Josef Köhrle

  136. Establishment of an Effective Radioiodide Thyroid Ablation Protocol in Mice

    Article • European Thyroid Journal, January 2015, Bioscientifica

    Josef Köhrle

  137. High T3, Low T4 Serum Levels in Mct8 Deficiency Are Not Caused by Increased Hepatic Conversion through Type I Deiodinase

    Article • European Thyroid Journal, January 2015, Bioscientifica

    Josef Köhrle

  138. Involvement of the L-Type Amino Acid Transporter Lat2 in the Transport of 3,3′-Diiodothyronine across the Plasma Membrane

    Article • European Thyroid Journal, January 2015, Bioscientifica

    Josef Köhrle

  139. Quantitative Analysis of Thyroid Hormone Metabolites in Cell Culture Samples Using LC-MS/MS

    Article • European Thyroid Journal, January 2015, Bioscientifica

    Josef Köhrle

  140. Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies

    Article • European Thyroid Journal, January 2015, Bioscientifica

    Josef Köhrle

  141. The Multitarget Ligand 3-Iodothyronamine Modulates β-Adrenergic Receptor 2 Signaling

    Article • European Thyroid Journal, January 2015, Bioscientifica

    Josef Köhrle

  142. Urine Metabolomics by 1H-NMR Spectroscopy Indicates Associations between Serum 3,5-T2 Concentrations and Intermediary Metabolism in Euthyroid Humans

    Article • European Thyroid Journal, January 2015, Bioscientifica

    Josef Köhrle

  143. Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile

    Article • International Journal of Molecular Sciences, November 2014, MDPI AG

    Josef Köhrle

  144. High Serum Thyrotropin Levels Are Associated with Retinal Arteriolar Narrowing in the General Population

    Article • Thyroid, October 2014, Mary Ann Liebert Inc

    Josef Köhrle

  145. Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries

    Article • Expert Review of Endocrinology & Metabolism, September 2014, Taylor & Francis

    Professor Lutz Schomburg, Josef Köhrle

  146. Detection of 3,5-Diiodothyronine in Sera of Patients with Altered Thyroid Status Using a New Monoclonal Antibody-Based Chemiluminescence Immunoassay

    Article • Thyroid, September 2014, Mary Ann Liebert Inc

    Josef Köhrle

  147. Hepatic metabolite profiles in mice with a suboptimal selenium status

    Article • The Journal of Nutritional Biochemistry, September 2014, Elsevier

    Josef Köhrle

  148. Thyroxine: beneficial for mutated TRα receptors thwarting thyroid hormone action?

    Article • The Lancet Diabetes & Endocrinology, August 2014, Elsevier

    Josef Köhrle

  149. Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

    Article • Proceedings of the National Academy of Sciences, July 2014, Proceedings of the National Academy of Sciences

    Josef Köhrle

  150. Soy isoflavones interfere with thyroid hormone homeostasis in orchidectomized middle-aged rats

    Article • Toxicology and Applied Pharmacology, July 2014, Elsevier

    Josef Köhrle

  151. Transport of Thyroid Hormone in Brain

    Article • Frontiers in Endocrinology, June 2014, Frontiers

    Josef Köhrle

  152. Screening assays on inhibitors, modulators and substrates of deiodinase and dehalogenase activities

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2014, Thieme Publishing Group

    Josef Köhrle

  153. The mouse Leydig cell line MLTC-1 prefers L-thyroxine over 3,3',5-triiodo-L-thyronine in transport across plasma membrane and shows steroidogenesis response to thyroid hormone treatment

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2014, Thieme Publishing Group

    Josef Köhrle

  154. Aspects of 3-iodothyronamine (3T1AM) induced signaling by human and mouse trace amine-associated receptor 5 (TAAR5)

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2014, Thieme Publishing Group

    Josef Köhrle

  155. Evidence for thyromimetic action of 3,5-T2 in diet-induced obese mice

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2014, Thieme Publishing Group

    Josef Köhrle

  156. Functional and metabolic responses of thyrocytes to 3-Iodothyronamine (3-T1AM)

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2014, Thieme Publishing Group

    Josef Köhrle

  157. Role of 3,5-diiodothyronine in chronic kidney disease

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2014, Thieme Publishing Group

    Josef Köhrle

  158. Supplementieren oder nicht? Das Spurenelement Selen

    Article • Perspectives in Medicine, March 2014, Elsevier

    Josef Köhrle

  159. Hormone des Hypothalamus und der Hypophyse

    Article • January 2014, Springer Science + Business Media

    Josef Köhrle

  160. Schilddrüsenhormone – Zentrale Regulatoren von Entwicklung, Wachstum, Grundumsatz, Stoffwechsel und Zelldifferenzierung

    Article • January 2014, Springer Science + Business Media

    Josef Köhrle

  161. Steroidhormone – Produkte von Nebennierenrinde und Keimdrüsen

    Article • January 2014, Springer Science + Business Media

    Josef Köhrle

  162. Wachstumshormon und Prolactin

    Article • January 2014, Springer Science + Business Media

    Josef Köhrle

  163. Selenium and the thyroid

    Article • Current Opinion in Endocrinology Diabetes and Obesity, October 2013, Wolters Kluwer Health

    Josef Köhrle

  164. Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies

    Article • Clinical Endocrinology, July 2013, Wiley

    Professor Lutz Schomburg, Josef Köhrle

  165. Function of thyroid hormone transporters in the central nervous system

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2013, Elsevier

    Josef Köhrle

  166. Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review

    Article • Environmental Health Perspectives, July 2013, Environmental Health Perspectives

    Josef Köhrle

  167. Thyroid Hormone Disruptors and In Vitro Screening

    Article • Toxicology in Vitro, June 2013, Elsevier

    Dr Kevin M Crofton, Josef Köhrle

  168. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study,,

    Article • American Journal of Clinical Nutrition, April 2013, Elsevier

    Professor Lutz Schomburg, Josef Köhrle

  169. Serum selenium is low in newly diagnosed Graves’ disease: a population-based study

    Article • Clinical Endocrinology, March 2013, Wiley

    Professor Lutz Schomburg, Josef Köhrle

  170. Establishment of a competitive chemiluminescence immunoassay to detect 3,5-T2 in human serum

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2013, Thieme Publishing Group

    Josef Köhrle

  171. Strong associations of 25-hydroxyvitamin D levels with all-cause, cardiovascular, cancer and respiratory disease mortality in a large cohort study

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2013, Thieme Publishing Group

    Josef Köhrle

  172. Thyroid hormone transporters during testicular development in rodents

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2013, Thieme Publishing Group

    Josef Köhrle

  173. Serum 25-Hydroxyvitamin D and Cancer Risk in Older Adults: Results from a Large German Prospective Cohort Study

    Article • Cancer Epidemiology Biomarkers & Prevention, March 2013, American Association for Cancer Research (AACR)

    Professor Lutz Schomburg, Josef Köhrle

  174. Autoantibodies to the IGF1 Receptor in Graves' Orbitopathy

    Article • The Journal of Clinical Endocrinology & Metabolism, February 2013, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  175. Se- and S-Based Thiouracil and Methimazole Analogues Exert Different Inhibitory Mechanisms on Type 1 and Type 2 Deiodinases

    Article • European Thyroid Journal, January 2013, Bioscientifica

    Josef Köhrle

  176. Bone Turnover and Bone Mineral Density Are Independently Related to Selenium Status in Healthy Euthyroid Postmenopausal Women

    Article • The Journal of Clinical Endocrinology & Metabolism, November 2012, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  177. Standardization of Misleading Immunoassay Based 25-Hydroxyvitamin D Levels with Liquid Chromatography Tandem-Mass Spectrometry in a Large Cohort Study

    Article • PLOS One, November 2012, PLOS

    Professor Lutz Schomburg, Josef Köhrle

  178. Thyroid Function Is Maintained Despite Increased Oxidative Stress in Mice Lacking Selenoprotein Biosynthesis in Thyroid Epithelial Cells

    Article • Antioxidants & Redox Signaling, September 2012, Mary Ann Liebert Inc

    Professor Lutz Schomburg, Josef Köhrle

  179. Orchidectomy of middle-aged rats decreases liver deiodinase 1 and pituitary deiodinase 2 activity

    Article • September 2012, Bioscientifica

    Branka Sosic-Jurjevic, Josef Köhrle

  180. LC–MS/MS detection of thyroid hormone metabolites in tissue samples

    Article • Expert Review of Endocrinology & Metabolism, September 2012, Taylor & Francis

    Josef Köhrle

  181. Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia

    Article • International Journal of Cancer, July 2012, Wiley

    Josef Köhrle

  182. Identification of Iopanoic Acid as Substrate of Type 1 Deiodinase by a Novel Nonradioactive Iodide-Release Assay

    Article • Endocrinology, May 2012, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  183. Selen

    Article • March 2012, Wiley

    Josef Köhrle

  184. Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans

    Article • The Journal of Clinical Endocrinology & Metabolism, February 2012, Endocrine Society

    Professor Luzia Valentini, Josef Köhrle

  185. Does the aromatic l-amino acid decarboxylase contribute to thyronamine biosynthesis?

    Article • Molecular and Cellular Endocrinology, February 2012, Elsevier

    Oliver Blankenstein, Josef Köhrle

  186. Tyrosine Kinase Inhibitors Noncompetitively Inhibit MCT8-Mediated Iodothyronine Transport

    Article • The Journal of Clinical Endocrinology & Metabolism, January 2012, Endocrine Society

    Josef Köhrle

  187. Selenium

    Article • January 2012, Springer Science + Business Media

    Josef Köhrle

  188. Differential Modulation of Beta-Adrenergic Receptor Signaling by Trace Amine-Associated Receptor 1 Agonists

    Article • PLOS One, October 2011, PLOS

    Josef Köhrle

  189. Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture

    Article • The Journal of Nutritional Biochemistry, October 2011, Elsevier

    Professor Lutz Schomburg, Josef Köhrle

  190. Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy

    Article • European Journal of Endocrinology, October 2011, Oxford University Press (OUP)

    Josef Köhrle

  191. Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8

    Article • Biochemical Journal, September 2011, Portland Press Ltd.

    Josef Köhrle

  192. Faculty Opinions recommendation of Reduction of thyroid nodule volume by levothyroxine and iodine alone and in combination: a randomized, placebo-controlled trial.

    Article • August 2011, F1000Research

    Josef Köhrle

  193. Copeptin and Peroxiredoxin-4 Independently Predict Mortality in Patients With Nonspecific Complaints Presenting to the Emergency Department

    Article • Academic Emergency Medicine, August 2011, Wiley

    Josef Köhrle

  194. Environmental factors

    Article • July 2011, Oxford University Press (OUP)

    Josef Köhrle

  195. Faculty Opinions recommendation of Selenium and the course of mild Graves' orbitopathy.

    Article • June 2011, F1000Research

    Josef Köhrle

  196. Evidence for Extrathyroidal Formation of 3-Iodothyronamine in Humans as Provided by a Novel Monoclonal Antibody-Based Chemiluminescent Serum Immunoassay

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2011, Endocrine Society

    Josef Köhrle

  197. Circulating Levels of Peroxiredoxin 4 as a Novel Biomarker of Oxidative Stress in Patients with Sepsis: Erratum

    Article • Shock, June 2011, Wolters Kluwer Health

    Josef Köhrle

  198. Circulating Levels of Peroxiredoxin 4 as a Novel Biomarker of Oxidative Stress in Patients with Sepsis

    Article • Shock, May 2011, Wolters Kluwer Health

    Josef Köhrle

  199. Faculty Opinions recommendation of The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomized, double-blind, crossover study.

    Article • April 2011, F1000Research

    Josef Köhrle

  200. Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency

    Article • European Journal of Endocrinology, April 2011, Oxford University Press (OUP)

    Professor Lutz Schomburg, Josef Köhrle

  201. Thyronamines—Past, Present, and Future

    Article • Endocrine Reviews, February 2011, Endocrine Society

    Josef Köhrle

  202. Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information

    Article • Thyroid Research, January 2011, Springer Science + Business Media

    Josef Köhrle

  203. Selenium Transport in Mammals: Selenoprotein P and Its Receptors

    Article • January 2011, Springer Science + Business Media

    Josef Köhrle

  204. Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells

    Article • Glia, December 2010, Wiley

    Josef Köhrle

  205. Faculty Opinions recommendation of Tissue distribution and cardiac metabolism of 3-iodothyronamine.

    Article • December 2010, F1000Research

    Josef Köhrle

  206. Report on the 4th International FESTEM Symposium on “Recent advances in trace element research: From experiments to nutritional and clinical applications in humans” (Saint Petersburg, Russia, June 09–12th, 2010)

    Article • Journal of Trace Elements in Medicine and Biology, October 2010, Elsevier

    Josef Köhrle

  207. Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain

    Article • Biochemical Journal, September 2010, Portland Press Ltd.

    Professor Lutz Schomburg, Josef Köhrle

  208. Immunoluminometric assay for quantification of peroxiredoxin 4 in human serum

    Article • Clinica Chimica Acta, September 2010, Elsevier

    Josef Köhrle

  209. Essential Molecular Determinants for Thyroid Hormone Transport and First Structural Implications for Monocarboxylate Transporter 8

    Article • Journal of Biological Chemistry, September 2010, Elsevier

    Josef Köhrle

  210. Faculty Opinions recommendation of A coherent organization of differentiation proteins is required to maintain an appropriate thyroid function in the Pendred thyroid.

    Article • August 2010, F1000Research

    Josef Köhrle

  211. Proteomic approach reveals novel targets for retinoic acid-mediated therapy of thyroid carcinoma

    Article • Molecular and Cellular Endocrinology, August 2010, Elsevier

    Josef Köhrle

  212. Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism

    Article • Molecular Nutrition & Food Research, July 2010, Wiley

    Josef Köhrle

  213. Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 2010, Elsevier

    Josef Köhrle

  214. Synthese, Stoffwechsel und Diagnostik der Schilddrüsenhormone

    Article • Der Internist, April 2010, Springer Science + Business Media

    Josef Köhrle

  215. Midregional Proenkephalin A and N-terminal Protachykinin A are decreased in the cerebrospinal fluid of patients with dementia disorders and acute neuroinflammation

    Article • Journal of Neuroimmunology, April 2010, Elsevier

    Josef Köhrle

  216. Faculty Opinions recommendation of Thyrostimulin, but not thyroid-stimulating hormone (TSH), acts as a paracrine regulator to activate the TSH receptor in mammalian ovary.

    Article • January 2010, F1000Research

    Josef Köhrle

  217. Secretion of Antioxidant Peroxiredoxin 4 in Response to Oxidative Stress

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Josef Köhrle

  218. Increased risk of thyroid pathology in patients with thyroid hemiagenesis: results of a large cohort case–control study

    Article • European Journal of Endocrinology, January 2010, Oxford University Press (OUP)

    Josef Köhrle

  219. Selenium and thyroid

    Article • Best Practice & Research Clinical Endocrinology & Metabolism, December 2009, Elsevier

    Josef Köhrle

  220. Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

    Article • The FASEB Journal, November 2009, Wiley

    Professor Lutz Schomburg, Josef Köhrle

  221. Reduced Serum Selenoprotein P Concentrations in German Prostate Cancer Patients

    Article • Cancer Epidemiology Biomarkers & Prevention, August 2009, American Association for Cancer Research (AACR)

    Professor Klaus Jung, Professor Lutz Schomburg, Josef Köhrle

  222. Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent

    Article • Journal of Molecular Endocrinology, July 2009, Bioscientifica

    Josef Köhrle

  223. Neuronal 3′,3,5-Triiodothyronine (T3) Uptake and Behavioral Phenotype of Mice Deficient inMct8, the Neuronal T3Transporter Mutated in Allan–Herndon–Dudley Syndrome

    Article • Journal of Neuroscience, July 2009, Society for Neuroscience

    Josef Köhrle

  224. Expression of Iodothyronine Deiodinase in Cultured Thyroid Cells

    Article • Experimental and Clinical Endocrinology & Diabetes, July 2009, Thieme Publishing Group

    Josef Köhrle

  225. Thyroid hormone deiodination in target tissues — a regulatory role for the trace dement selenium?

    Article • Experimental and Clinical Endocrinology & Diabetes, July 2009, Thieme Publishing Group

    Josef Köhrle

  226. Interference of Endocrine Disrupters with Thyroid Hormone Receptor–Dependent Transactivation

    Article • Toxicological Sciences, April 2009, Oxford University Press (OUP)

    Professor Lutz Schomburg, Josef Köhrle

  227. Selenium Supplementation Fails to Correct the Selenoprotein Synthesis Defect in Subjects with SBP2 Gene Mutations

    Article • Thyroid, March 2009, Mary Ann Liebert Inc

    Professor Lutz Schomburg, Josef Köhrle

  228. Down‐regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice

    Article • The FASEB Journal, January 2009, Wiley

    Professor Lutz Schomburg, Josef Köhrle

  229. Faculty Opinions recommendation of Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation.

    Article • January 2009, F1000Research

    Josef Köhrle

  230. Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines

    Article • Journal of Molecular Endocrinology, December 2008, Bioscientifica

    Josef Köhrle

  231. On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health

    Article • Molecular Nutrition & Food Research, November 2008, Wiley

    Professor Lutz Schomburg, Josef Köhrle

  232. V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis

    Article • AJP Renal Physiology, October 2008, American Physiological Society

    Professor Lutz Schomburg, Josef Köhrle

  233. Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates

    Article • Rapid Communications in Mass Spectrometry, September 2008, Wiley

    Josef Köhrle

  234. Peroxides and Peroxide-Degrading Enzymes in the Thyroid

    Article • Antioxidants & Redox Signaling, September 2008, Mary Ann Liebert Inc

    Josef Köhrle

  235. Faculty Opinions recommendation of A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity.

    Article • August 2008, F1000Research

    Josef Köhrle

  236. Detection of stable N-terminal protachykinin A immunoreactivity in human plasma and cerebrospinal fluid

    Article • Peptides, July 2008, Elsevier

    Josef Köhrle

  237. Faculty Opinions recommendation of Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.

    Article • June 2008, F1000Research

    Josef Köhrle

  238. Thyronamines Are Isozyme-Specific Substrates of Deiodinases

    Article • Endocrinology, June 2008, Endocrine Society

    Josef Köhrle

  239. Thyroid disrupting chemicals: mechanisms and mixtures

    Article • International Journal of Andrology, April 2008, Wiley

    Dr Kevin M Crofton, Josef Köhrle

  240. Environment and endocrinology: The case of thyroidology

    Article • Annales d Endocrinologie, April 2008, Elsevier

    Josef Köhrle

  241. New assay for the measurement of selenoprotein P as a sepsis biomarker from serum

    Article • Journal of Trace Elements in Medicine and Biology, March 2008, Elsevier

    Professor Lutz Schomburg, Josef Köhrle

  242. Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice

    Article • Biochemical Journal, January 2008, Portland Press Ltd.

    Professor Lutz Schomburg, Josef Köhrle

  243. Welcome to Thyroid Research

    Article • Thyroid Research, January 2008, Springer Science + Business Media

    Josef Köhrle

  244. Phthalates: metabolism and exposure

    Article • International Journal of Andrology, December 2007, Wiley

    Josef Köhrle

  245. Endocrine Disruptors and the Thyroid Gland—A Combined in Vitro and in Vivo Analysis of Potential New Biomarkers

    Article • Environmental Health Perspectives, December 2007, Environmental Health Perspectives

    Josef Köhrle

  246. The KiSS‐1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic–pituitary unit?

    Article • International Journal of Andrology, October 2007, Wiley

    Josef Köhrle

  247. Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3

    Article • Biological Chemistry, October 2007, De Gruyter

    Professor Lutz Schomburg, Josef Köhrle

  248. Selenoproteins – biochemistry and clinical relevance

    Article • Biological Chemistry, October 2007, De Gruyter

    Josef Köhrle

  249. Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary–thyroid function in rats

    Article • Toxicology, September 2007, Elsevier

    Josef Köhrle

  250. Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation

    Article • Journal of Neuroimmunology, September 2007, Elsevier

    Josef Köhrle

  251. The Ultraviolet Filter Benzophenone 2 Interferes with the Thyroid Hormone Axis in Rats and Is a Potentin VitroInhibitor of Human Recombinant Thyroid Peroxidase

    Article • Endocrinology, June 2007, Endocrine Society

    Josef Köhrle

  252. Thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination

    Article • Best Practice & Research Clinical Endocrinology & Metabolism, June 2007, Elsevier

    Josef Köhrle

  253. Neuronal and ependymal expression of selenoprotein P in the human brain

    Article • Acta Neurovegetativa, January 2007, Springer Science + Business Media

    Professor Lutz Schomburg, Josef Köhrle

  254. Hypothalamisch-hypophysäres System und Zielgewebe

    Article • January 2007, Springer Science + Business Media

    Josef Köhrle

  255. Selenium-Dependent Pre- and Posttranscriptional Mechanisms Are Responsible for Sexual Dimorphic Expression of Selenoproteins in Murine Tissues

    Article • Endocrinology, December 2006, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  256. Selenium and goiter prevalence in borderline iodine sufficiency

    Article • European Journal of Endocrinology, December 2006, Oxford University Press (OUP)

    Josef Köhrle

  257. Effects of isoflavonoids and other plant-derived compounds on the hypothalamus–pituitary–thyroid hormone axis

    Article • Maturitas, November 2006, Elsevier

    Josef Köhrle

  258. Contributions of cytokines to nonthyroidal illness

    Article • Current Opinion in Endocrinology and Diabetes, October 2006, Wolters Kluwer Health

    Josef Köhrle

  259. Proenkephalin A 119–159, a stable proenkephalin A precursor fragment identified in human circulation

    Article • Peptides, July 2006, Elsevier

    Josef Köhrle

  260. Genistein and other soya isoflavones are potent ligands for transthyretin in serum and cerebrospinal fluid

    Article • British Journal Of Nutrition, June 2006, Cambridge University Press

    Josef Köhrle

  261. Distinct roles for neuronal selenoproteins in cerebellar development

    Article • April 2006, Elsevier

    Josef Köhrle

  262. Synthesis and Metabolism of Thyroid Hormones Is Preferentially Maintained in Selenium-Deficient Transgenic Mice

    Article • Endocrinology, March 2006, Endocrine Society

    Professor Lutz Schomburg, Josef Köhrle

  263. Selenium and goiter prevalence in borderline iodine sufficiency

    Article • Experimental and Clinical Endocrinology & Diabetes, February 2006, Thieme Publishing Group

    Josef Köhrle

  264. Nutritional Genomics

    Article • January 2006, Wiley

    Josef Köhrle

  265. Molekularmedizinische Grundlagen von para- und autokrinen Regulationsstörungen

    Article • January 2006, Springer Science + Business Media

    Josef Köhrle

  266. Selen – Selenoproteine – Selenmangel – Selenvergiftung

    Article • January 2006, Elsevier

    Josef Köhrle

  267. Selenium, the Thyroid, and the Endocrine System

    Article • Endocrine Reviews, December 2005, Endocrine Society

    Josef Köhrle

  268. Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice

    Article • Biochemical and Biophysical Research Communications, November 2005, Elsevier

    Professor Lutz Schomburg, Josef Köhrle

  269. Letter re: Id1 Gene Expression in Hyperplastic and Neoplastic Thyroid Tissues

    Article • The Journal of Clinical Endocrinology & Metabolism, October 2005, Endocrine Society

    Josef Köhrle

  270. Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels, but not for thyroid hormone-dependent gene expression

    Article • September 2005, Elsevier

    Josef Köhrle

  271. Purkinje cell degeneration and loss of cerebellar interneurons during development of mice lacking neuronal selenoprotein biosynthesis

    Article • September 2005, Elsevier

    Josef Köhrle

  272. Selenoprotein biosynthesis – importance of structural elements in the 3‘-untranslated region

    Article • September 2005, Elsevier

    Josef Köhrle

  273. Xanthohumol stimulates iodide uptake in rat thyroid-derived FRTL-5 cells

    Article • Molecular Nutrition & Food Research, September 2005, Wiley

    Josef Köhrle

  274. Selenium and the Control of Thyroid Hormone Metabolism

    Article • Thyroid, August 2005, Mary Ann Liebert Inc

    Josef Köhrle

  275. Free-flow isoelectric focusing of proteins remaining in cell fragments following sonication of thyroid carcinoma cells

    Article • Electrophoresis, June 2005, Wiley

    Josef Köhrle

  276. Selenoprotein Expression in Hürthle Cell Carcinomas and in the Human Hürthle Cell Carcinoma Line XTC.UC1

    Article • Thyroid, May 2005, Mary Ann Liebert Inc

    Josef Köhrle

  277. Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish

    Article • AJP Regulatory Integrative and Comparative Physiology, May 2005, American Physiological Society

    Josef Köhrle

  278. Tissue-specific growth-defects upon Selenium-deficiency

    Article • Experimental and Clinical Endocrinology & Diabetes, March 2005, Thieme Publishing Group

    Josef Köhrle

  279. Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply

    Article • Biochemical Journal, February 2005, Portland Press Ltd.

    Professor Lutz Schomburg, Josef Köhrle

  280. Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney

    Article • Toxicology, December 2004, Elsevier

    Professor Lutz Schomburg, Josef Köhrle

  281. Guard Your Master: Thyroid Hormone Receptors Protect Their Gland of Origin from Thyroid Cancer

    Article • Endocrinology, October 2004, Endocrine Society

    Josef Köhrle

  282. CD82, and CD63 in thyroid cancer.

    Article • International Journal of Molecular Medicine, October 2004, Spandidos Publications

    Josef Köhrle

  283. Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation

    Article • The Lancet, October 2004, Elsevier

    Josef Köhrle

  284. Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis

    Article • European Journal of Endocrinology, October 2004, Oxford University Press (OUP)

    Josef Köhrle

  285. Selenium in biology and medicine—further progress and increasing interest

    Article • Journal of Trace Elements in Medicine and Biology, September 2004, Elsevier

    Josef Köhrle

  286. Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic

    Article • Cellular and Molecular Life Sciences, August 2004, Springer Science + Business Media

    Professor Lutz Schomburg, Josef Köhrle

  287. 55th Mosbach Colloquium: How nutrients influence gene activity

    Article • Biological Chemistry, July 2004, De Gruyter

    Josef Köhrle

  288. Selenium and brain function: a poorly recognized liaison

    Article • Brain Research Reviews, July 2004, Elsevier

    Josef Köhrle

  289. Human thyroid carcinoma cell lines show different retinoic acid receptor repertoires and retinoid responses

    Article • European Journal of Endocrinology, April 2004, Oxford University Press (OUP)

    Josef Köhrle

  290. Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency

    Article • Biochemical Journal, February 2004, Portland Press Ltd.

    Professor Lutz Schomburg, Josef Köhrle

  291. Contribution of Interleukin-12 to the Pathogenesis of Non-thyroidal Illness

    Article • Hormone and Metabolic Research, February 2004, Thieme Publishing Group

    Josef Köhrle

  292. Expression of CD97 and CD55 in human medullary thyroid carcinomas

    Article • International Journal of Oncology, February 2004, Spandidos Publications

    Josef Köhrle

  293. Thyroid Hormone Metabolism

    Article • January 2004, Elsevier

    Josef Köhrle

  294. Exciting new perspectives and further necessity for selenium research in Europe

    Article • Journal of Trace Elements in Medicine and Biology, January 2004, Elsevier

    Josef Köhrle

  295. Expression Profiling and Genetic Alterations of the Selenoproteins GI-GPx and SePP in Colorectal Carcinogenesis

    Article • Nutrition and Cancer, January 2004, Taylor & Francis

    Josef Köhrle

  296. Selenium Supplementation Enhances Low Selenium Levels and Stimulates Glutathione Peroxidase Activity in Peripheral Blood and Distal Colon Mucosa in Past and Present Carriers of Colon Adenomas

    Article • Nutrition and Cancer, July 2003, Taylor & Francis

    Josef Köhrle

  297. Glutathione peroxidase isoforms as part of the local antioxidative defense system in normal and Barrett's esophagus

    Article • International Journal of Cancer, March 2003, Wiley

    Josef Köhrle

  298. Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

    Article • Biochemical Journal, March 2003, Portland Press Ltd.

    Professor Lutz Schomburg, Josef Köhrle

  299. The Impact of Iron and Selenium Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health

    Article • Thyroid, October 2002, Mary Ann Liebert Inc

    Josef Köhrle

  300. A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency

    Article • European Journal of Human Genetics, August 2002, Springer Science + Business Media

    Josef Köhrle

  301. Expression of telomerase genes in thyroid carcinoma

    Article • International Journal of Oncology, August 2002, Spandidos Publications

    Josef Köhrle

  302. Expression of 5'-deiodinase enzymes in normal pituitaries and in various human pituitary adenomas

    Article • European Journal of Endocrinology, August 2002, Oxford University Press (OUP)

    Josef Köhrle

  303. Thyroid hormone receptors and type I iodothyronine 5′-deiodinase activity of human thyroid toxic adenomas and benign cold nodules

    Article • Experimental and Clinical Endocrinology & Diabetes, June 2002, Thieme Publishing Group

    Josef Köhrle

  304. Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodinase in HepG2 hepatocarcinoma cells

    Article • European Journal of Endocrinology, April 2002, Oxford University Press (OUP)

    Josef Köhrle

  305. Clinical impact of retinoids in redifferentiation therapy of advanced thyroid cancer: final results of a pilot study

    Article • European Journal of Pediatrics, March 2002, Springer Science + Business Media

    Josef Köhrle

  306. The promoter of the human sodium/iodide-symporter gene responds to retinoic acid

    Article • Molecular and Cellular Endocrinology, March 2002, Elsevier

    Josef Köhrle

  307. Stoffwechselerkrankungen

    Article • January 2002, Thieme Publishing Group

    Josef Köhrle

  308. Innentitel

    Article • January 2002, Thieme Publishing Group

    Josef Köhrle

  309. Iodothyronine Deiodinases

    Article • January 2002, Elsevier

    Josef Köhrle

  310. Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway

    Article • Cytogenetic and Genome Research, January 2002, Karger Publishers

    Josef Köhrle

  311. Vitamine, Spurenelemente und Mineralstoffe

    Article • January 2002, Thieme Publishing Group

    Josef Köhrle

  312. Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor‐β

    Article • FEBS Journal, December 2001, Wiley

    Josef Köhrle

  313. Modulation of selenoprotein P expression by TGF‐β1 is mediated by Smad proteins

    Article • BioFactors, January 2001, Wiley

    Josef Köhrle

  314. The deiodinase family: selenoenzymes regulating thyroid hormone availability and action

    Article • Cellular and Molecular Life Sciences, December 2000, Springer Science + Business Media

    Josef Köhrle

  315. Effects of proinflammatory cytokines on anterior pituitary 5'-deiodinase type I and type II

    Article • Journal of Endocrinology, December 2000, Bioscientifica

    Josef Köhrle

  316. Innovative strategies for the treatment of thyroid cancer

    Article • European Journal of Endocrinology, July 2000, Oxford University Press (OUP)

    Josef Köhrle

  317. Inverse mRNA Expression of the Selenocysteine-Containing Proteins GI-GPx and SeP in Colorectal Adenomas Compared With Adjacent Normal Mucosa

    Article • Nutrition and Cancer, May 2000, Taylor & Francis

    Josef Köhrle

  318. Retinoic Acid Redifferentiation Therapy for Thyroid Cancer

    Article • Thyroid, May 2000, Mary Ann Liebert Inc

    Josef Köhrle

  319. Loss of selenoprotein P (SeP) expression in colorectal adenomas: Implications for carcinogenesis

    Article • Gastroenterology, April 2000, Elsevier

    Josef Köhrle

  320. Characterization of Barrett's and regenerative squamous mucosa by muc1 and muc2 mRNA expression

    Article • Gastroenterology, April 2000, Elsevier

    Josef Köhrle

  321. Analysis of the selenoprotein P promoter in colorectal carcinogenesis

    Article • Gastroenterology, April 2000, Elsevier

    Josef Köhrle

  322. Thyroid Hormone Metabolism and Action in the Brain and Pituitary

    Article • Acta Medica Austriaca, March 2000, Wiley

    Josef Köhrle

  323. Thyroid Hormone Metabolism and Action in the Brain and Pituitary

    Article • Acta Medica Austriaca, March 2000, Wiley

    Josef Köhrle

  324. Selenium in Biology: Facts and Medical Perspectives

    Article • Biological Chemistry, January 2000, De Gruyter

    Josef Köhrle

  325. Article • Reviews in Endocrine and Metabolic Disorders, January 2000, Springer Science + Business Media

    Josef Köhrle

  326. The influence of the cytokines Il‐1β and INFγ on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2

    Article • BioFactors, January 2000, Wiley

    Josef Köhrle

  327. Increased I-131 Uptake in Local Recurrence and Distant Metastases After Second Treatment With Retinoic Acid

    Article • Clinical Nuclear Medicine, November 1999, Wolters Kluwer Health

    Josef Köhrle

  328. Transforming growth factor‐β1 inhibits expression of selenoprotein P in cultured human liver cells

    Article • FEBS Letters, October 1999, Wiley

    Josef Köhrle

  329. Expression of selenoproteins in monocytes and macrophages — Implications for the immune system

    Article • Medizinische Klinik, October 1999, Springer Science + Business Media

    Regina Ebert, Josef Köhrle

  330. Local activation and inactivation of thyroid hormones: the deiodinase family

    Article • Molecular and Cellular Endocrinology, May 1999, Elsevier

    Josef Köhrle

  331. The trace element selenium and the thyroid gland

    Article • Biochimie, May 1999, Elsevier

    Josef Köhrle

  332. Type 1 deiodinase is stimulated by iodothyronines and involved in thyroid hormone metabolism in human somatomammotroph GX cells

    Article • European Journal of Endocrinology, April 1999, Oxford University Press (OUP)

    Josef Köhrle

  333. Regulation of CD97 Protein in Thyroid Carcinoma1

    Article • The Journal of Clinical Endocrinology & Metabolism, March 1999, Endocrine Society

    Josef Köhrle

  334. The selenoprotein thioredoxin reductase is expressed in peripheral blood monocytes and THP1 human myeloid leukemia cells - regulation by 1,25-dihydroxyvitamin D3and selenite

    Article • BioFactors, January 1999, Wiley

    Regina Ebert, Josef Köhrle

  335. Selensupplementation durch Selenhefe und Natriumselenit: Analyse des Selenstatus sowie Risiken des Mangels und der Intoxikation. Selenium Supplementation by Selenium Yeast and Sodium Selenite: Analysis of the Selenium Status as well as Risks of Deficie...

    Article • LaboratoriumsMedizin, January 1999, De Gruyter

    Josef Köhrle

  336. Reverse Transcriptase-Polymerase Chain Reaction Analysis of Thyrocyte-Relevant Genes in Fine-Needle Aspiration Biopsies of the Human Thyroid

    Article • Thyroid, November 1998, Mary Ann Liebert Inc

    Regina Ebert, Josef Köhrle

  337. Wie kommt Jod in die Schilddr�se?

    Article • Der Internist, June 1998, Springer Science + Business Media

    Josef Köhrle

  338. Redifferentiation Therapy with Retinoids: Therapeutic Option for Advanced Follicular and Papillary Thyroid Carcinoma

    Article • Extremophiles, June 1998, Wiley

    Josef Köhrle

  339. Functional retinoid and thyroid hormone receptors in human thyroid-carcinoma cell lines and tissues

    Article • International Journal of Cancer, May 1998, Wiley

    Josef Köhrle

  340. Functional retinoid and thyroid hormone receptors in human thyroid‐carcinoma cell lines and tissues

    Article • International Journal of Cancer, May 1998, Wiley

    Josef Köhrle

  341. Retinoic Acid Increases Sodium/Iodide Symporter mRNA Levels in Human Thyroid Cancer Cell Lines and Suppresses Expression of Functional Symporter in Nontransformed FRTL-5 Rat Thyroid Cells

    Article • Biochemical and Biophysical Research Communications, May 1998, Elsevier

    Josef Köhrle

  342. European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel

    Article • CA A Cancer Journal for Clinicians, May 1998, Wiley

    Josef Köhrle

  343. The Human Analog of Murine Cystein Rich Protein 16 Is a 1α,25-Dihydroxyvitamin D3Responsive Immediate Early Gene in Human Fetal Osteoblasts: Regulation by Cytokines, Growth Factors, and Serum1

    Article • Endocrinology, April 1998, Endocrine Society

    Josef Köhrle

  344. Selenoproteins Are Expressed in Fetal Human Osteoblast-like Cells

    Article • Biochemical and Biophysical Research Communications, April 1998, Elsevier

    Josef Köhrle

  345. Expression pattern of gastrointestinal selenoproteins— targets for selenium supplementation

    Article • Nutrition and Cancer, January 1998, Taylor & Francis

    Josef Köhrle

  346. Identification by differential display PCR of the selenoprotein thioredoxin reductase as a 1α,25(OH)_2‐vitamin D_3‐responsive gene in human osteoblasts — regulation by selenite

    Article • BioFactors, January 1998, Wiley

    Josef Köhrle

  347. Discussion

    Article • Trends in Endocrinology and Metabolism, December 1997, Elsevier

    Josef Köhrle

  348. Cloning and Characterization of the Human Selenoprotein P Promoter

    Article • Journal of Biological Chemistry, November 1997, Elsevier

    Josef Köhrle

  349. Retinoic Acid Increases Sodium/Iodide Symporter mRNA Levels in Human Thyroid Cancer Cell Lines and Suppresses Expression of Functional Symporter in Nontransformed FRTL-5 Rat Thyroid Cells

    Article • Biochemical and Biophysical Research Communications, November 1997, Elsevier

    Josef Köhrle

  350. Selenoproteine im Knochen, Gastrointestinaltrakt und in der Schilddrüse des Menschen

    Article • Medizinische Klinik, September 1997, Springer Science + Business Media

    Josef Köhrle

  351. 3,5-Diiodo-l-Thyronine Stimulates Type 1 5′Deiodinase Activity in Rat Anterior Pituitariesin Vivoand in Reaggregate Cultures and GH3 Cellsin Vitro1

    Article • Endocrinology, August 1997, Endocrine Society

    Josef Köhrle

  352. Consensus statement on lung cancer

    Article • European Journal of Cancer Prevention, August 1997, Wolters Kluwer Health

    Josef Köhrle

  353. 3,5-Diiodo-L-Thyronine Stimulates Type 1 5'Deiodinase Activity in Rat Anterior Pituitaries in Vivo and in Reaggregate Cultures and GH3 Cells in Vitro

    Article • Endocrinology, August 1997, Endocrine Society

    Josef Köhrle

  354. The Promoter of the Human Type I 5′‐Deiodinase Gene — Mapping of the Transcription Start Site and Identification of a DR+4 Thyroid‐Hormone‐Responsive Element

    Article • FEBS Journal, July 1997, Wiley

    Josef Köhrle

  355. Structure of the Human Type I Iodothyronine 5′-Deiodinase Gene and Localization to Chromosome 1p32–p33

    Article • Genomics, June 1997, Elsevier

    Josef Köhrle

  356. Local estradiol metabolism in osteoblast- and osteoclast-like cells

    Article • The Journal of Steroid Biochemistry and Molecular Biology, April 1997, Elsevier

    Josef Köhrle

  357. Local Estradiol Metabolism in Osteoblast- and Osteoclast-like Cells

    Article • The Journal of Steroid Biochemistry and Molecular Biology, April 1997, Elsevier

    Josef Köhrle

  358. Different Tissue Distribution, Elimination, and Kinetics of Thyroxine and Its Conformational Analog, the Synthetic Flavonoid EMD 49209 in the Rat1

    Article • Endocrinology, January 1997, Endocrine Society

    Josef Köhrle

  359. Different Tissue Distribution, Elimination, and Kinetics of Thyroxine and Its Conformational Analog, the Synthetic Flavonoid EMD 49209 in the Rat

    Article • Endocrinology, January 1997, Endocrine Society

    Josef Köhrle

  360. Thyroid Carcinoma: Interrelationships Between Local Thyroid Hormone Metabolism by the Type I 5′-Deiodinase and the Expression of Thyroid Hormone Receptors and Other Thyroid-Specific (De-)differentiation Markers

    Article • January 1997, Springer Science + Business Media

    Josef Köhrle

  361. Selected Novel Flavones Inhibit the DNA Binding or the DNA Religation Step of Eukaryotic Topoisomerase I

    Article • Journal of Biological Chemistry, January 1996, Elsevier

    Josef Köhrle

  362. Binding of Thyroxine to Pig Transthyretin, its cDNA Structure, and Other Properties

    Article • FEBS Journal, June 1995, Wiley

    Josef Köhrle

  363. Binding of Thyroxine to Pig Transthyretin, its cDNA Structure, and Other Properties

    Article • FEBS Journal, June 1995, Wiley

    Josef Köhrle

  364. Expression and regulation of aromatase cytochrome P450 in THP 1 human myeloid leukaemia cells

    Article • Molecular and Cellular Endocrinology, April 1995, Elsevier

    Josef Köhrle

  365. Differential selenium-dependent expression of type I 5′-deiodinase and glutathione peroxidase in the porcine epithelial kidney cell line LLC-PK1

    Article • Biochemical Journal, March 1995, Portland Press Ltd.

    Josef Köhrle

  366. Rapid stimulation of type I 5′-deiodinase in rat pituitaries by 3,3′,5-triiodo-l-thyronine

    Article • Molecular and Cellular Endocrinology, February 1995, Elsevier

    Josef Köhrle

  367. Cloning of a cDNA encoding an ectoenzyme that degrades thyrotropin-releasing hormone.

    Article • Proceedings of the National Academy of Sciences, September 1994, Proceedings of the National Academy of Sciences

    Professor Lutz Schomburg, Josef Köhrle

  368. Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines.

    Article • The Journal of Clinical Endocrinology & Metabolism, September 1994, Endocrine Society

    Josef Köhrle

  369. Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines

    Article • The Journal of Clinical Endocrinology & Metabolism, September 1994, Endocrine Society

    Josef Köhrle

  370. Topoisomerase I Inhibition Enhances Vitamin D-Responsive Expression of the Receptor for Lipopolysaccharide Binding Protein CD 14

    Article • Biochemical and Biophysical Research Communications, March 1994, Elsevier

    Josef Köhrle

  371. Thyroxine transport to the brain: role of protein synthesis by the choroid plexus.

    Article • Endocrinology, November 1993, Endocrine Society

    Josef Köhrle

  372. Selective labelling and inactivation of creatine kinase isoenzymes by the thyroid hormone derivative N-bromoacetyl-3,3′,5-tri-iodo-l-thyronine

    Article • Biochemical Journal, April 1993, Portland Press Ltd.

    Josef Köhrle

  373. Selenium-dependent regulation of type I 5′-deiodinase expression

    Article • American Journal of Clinical Nutrition, February 1993, Elsevier

    Josef Köhrle

  374. Early adaptation of thyrotropin and thyroglobulin secretion to experimentally decreased iodine supply in man

    Article • Metabolism, October 1992, Elsevier

    Josef Köhrle

  375. Thyroxine (T4) transport and distribution in rats treated with EMD 21388, a synthetic flavonoid that displaces T4 from transthyretin.

    Article • Endocrinology, March 1992, Endocrine Society

    Josef Köhrle

  376. Thyroxine (T4) transport and distribution in rats treated with EMD 21388, a synthetic flavonoid that displaces T4 from transthyretin

    Article • Endocrinology, March 1992, Endocrine Society

    Josef Köhrle

  377. Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain.

    Article • Endocrinology, February 1992, Endocrine Society

    Josef Köhrle

  378. Human thyrotropin receptor gene: Expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation

    Article • Molecular and Cellular Endocrinology, November 1991, Elsevier

    Josef Köhrle

  379. Localization of type I iodothyronine 5'-deiodinase to the basolateral plasma membrane in renal cortical epithelial cells

    Article • Journal of Biological Chemistry, June 1991, Elsevier

    Josef Köhrle

  380. Identification of type I iodothyronine 5′-deiodinase as a selenoenzyme

    Article • Biochemical and Biophysical Research Communications, December 1990, Elsevier

    Josef Köhrle

  381. Flavonoid Administration Immediately Displaces Thyroxine (T4) from Serum Transthyretin, Increases Serum Free T4, and Decreases Serum Thyrotropin in the Rat*

    Article • Endocrinology, June 1990, Endocrine Society

    Josef Köhrle

  382. 5′-Deiodination in Rat Hepatocytes: Effects of Specific Flavonoid Inhibitors*

    Article • Endocrinology, March 1990, Endocrine Society

    Josef Köhrle

  383. Effect of Biological Alterations of Type I 5'Deiodinase Activity on Affinity Labeled Membrane Proteins in Rat Liver and Kidney*

    Article • Endocrinology, February 1990, Endocrine Society

    Josef Köhrle

  384. Thyroid hormone effect on rat heart mitochondrial proteins and affinity labeling with N‐bromoacetyl‐3,3′,5‐triiodo‐L‐thyronine Lack of direct effect on the adenine nucleotide translocase

    Article • FEBS Letters, September 1989, Wiley

    Josef Köhrle

  385. Rapid Effects of the Flavonoid EMD 21388 on Serum Thyroid Hormone Binding and Thyrotropin Regulation in the Rat*

    Article • Endocrinology, July 1989, Endocrine Society

    Josef Köhrle

  386. Affinity-labelling of T4-5′-deiodinase and serum T4-binding proteins

    Article • European Journal of Endocrinology, June 1989, Oxford University Press (OUP)

    Josef Köhrle

  387. Circadian and Pulsatile Thyrotropin Secretion in Euthyroid Man Under the Influence of Thyroid Hormone and Glucocorticoid Administration*

    Article • The Journal of Clinical Endocrinology & Metabolism, July 1987, Endocrine Society

    Josef Köhrle

  388. Inhibition of rat liver iodothyronine deiodinase. Interaction of aurones with the iodothyronine ligand-binding site.

    Article • Journal of Biological Chemistry, September 1986, Elsevier

    Josef Köhrle

  389. Rat liver iodothyronine monodeiodinase. Evaluation of the iodothyronine ligand-binding site.

    Article • Journal of Biological Chemistry, September 1986, Elsevier

    Josef Köhrle

  390. Indicator, cosmetic and food dyes interfere with thyroid hormone metabolism

    Article • European Journal of Endocrinology, August 1986, Oxford University Press (OUP)

    Josef Köhrle

  391. Crystal structure of phlorizin and the iodothyronine deiodinase inhibitory activity of phloretin analogues

    Article • Biochemical Pharmacology, July 1986, Elsevier

    Josef Köhrle

  392. Design of Active Site-Directed Iodothyronine Deiodinase Ligands Using TBPA as a Binding Site Model

    Article • January 1986, Springer Science + Business Media

    Josef Köhrle

  393. Design of an active site model of type I iodothyronine deiodinase and development of optimized iodothyronine analogue enzyme ligands

    Article • European Journal of Endocrinology, April 1985, Oxford University Press (OUP)

    Josef Köhrle

  394. Structure-activity-relationships of ligands of rat liver iodothyronine deiodinase

    Article • Fresenius Zeitschrift für Analytische Chemie, January 1985, Springer Science + Business Media

    Josef Köhrle

  395. Phloretin and polyphloretinphosphate (PPP) - a synthetic high molecular weight phosphorylated polymer - inhibit microsomal membrane iodothyronine deiodinase (ITH-D)

    Article • European Journal of Endocrinology, December 1984, Oxford University Press (OUP)

    Josef Köhrle

  396. Antihormonal Effects of Plant Extracts: Iodothyronine Deiodinase of Rat Liver is Inhibited by Extracts and Secondary Metabolites of Plants

    Article • Hormone and Metabolic Research, April 1984, Thieme Publishing Group

    Josef Köhrle

  397. pH-dependency of iodothyronine metabolism in isolated perfused rat liver

    Article • Biochemical Journal, March 1982, Portland Press Ltd.

    Josef Köhrle

  398. A NEW CLASS OF IODOTHYRONINE DEIODINASE INHIBITORS

    Article • Biochemical Society Transactions, April 1981, Portland Press Ltd.

    Josef Köhrle

  399. Subcellular localization of thyroxine-5-deiodinase in rat liver

    Article • Journal of Endocrinological Investigation, January 1980, Springer Science + Business Media

    Josef Köhrle

  400. Conversion of T3 and rT3 to 3,3′-T2: pH dependency

    Article • Clinica Chimica Acta, November 1978, Elsevier

    Josef Köhrle

  401. ChemInform Abstract: PREPARATION OF (14C)‐P1,P5‐DI(ADENOSINE)5′‐PENTAPHOSPHATE BY DIRECT REACTION OF (14C)‐ADENOSINE 5′‐DIPHOSPHATE WITH ACTIVATED ADENOSINE 5′‐TRIPHOSPHATE

    Article • Chemischer Informationsdienst, November 1977, Wiley

    Josef Köhrle

  402. P1, P5-Bis-(5′-adenosyl)pentaphosphate: Is this Adenylate Kinase Inhibitor Substrate for Mitochondrial Processes?

    Article • Zeitschrift für Naturforschung C, October 1977, De Gruyter

    Josef Köhrle

  403. Darstellung von [14C]‐P1,P5‐Di(adenosin‐5′‐)pentaphosphat durch direkte Umsetzung von [14C]‐Adenosin‐5′‐diphosphat mit aktiviertem Adenosin‐′‐triphosphat

    Article • Justus Liebig s Annalen der Chemie, September 1977, Wiley

    Josef Köhrle

  404. Grundlagen der parakrinen, autokrinen und intrakrinen Regulation endokriner Organe

    Article • Springer Science + Business Media

    Josef Köhrle