What is it about?
Biomarkers indicate what is happening inside a living body. Beta-amyloid and tau, proteins found in cerebrospinal fluid, are important biomarkers markers of Alzheimer's disease. We show a relationship between higher perceived stress scores and beta-amyloid and tau in African Americans with evidence of cognitive impairment.
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Why is it important?
Previous research demonstrates a relationship between perceived stress and cognitive testing in African Americans with cognitive impairment. This study builds on that work and establishes biomarker evidence to support it.
Perspectives
Although reading scientific articles is not always exciting, writing this paper was a great experience. There is evidence that African Americans have an increased risk of Alzheimer's disease and report high-stress exposure. A relationship between stress and cognitive testing in African Americans with cognitive impairment has been observed. However, we sought to know whether changes in the brain support this observation. Our finding that stress has a relation to Alzheimer's disease biomarkers supports a biological connection between stress and cognitive impairment. The finding is most notable for African Americans with impaired cognition in the study group. It shows the important role that social and psychological factors can play in disease and related health disparities.
Antoine Trammell
Emory University
Read the Original
This page is a summary of: Perceived Stress is Associated with Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in African Americans with Mild Cognitive Impairment, Journal of Alzheimer s Disease, September 2020, IOS Press,
DOI: 10.3233/jad-200089.
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