What is it about?

We found that mania does occur after traumatic brain injury, but at a much lower rate than depression. When it does occur, often a combination of sodium valproate and atypical antipsychotics appears to be most effective.

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Why is it important?

It is important that clinicians recognise that mania can occur so that appropriate treatment is instituted, and that psychiatrists and neuropsychiatrists are mindful of the medication considerations in this patient group.

Perspectives

This is the first systematic review of mania in this population. Whilst depression remains the most common mood disorder in traumatic brain injury patients, recognition of mania is as crucial in this population as it is in the non-brain injured population.

Mark Walterfang
University of Melbourne

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This page is a summary of: Mania Following Traumatic Brain Injury: A Systematic Review, Journal of Neuropsychiatry, April 2023, American Psychiatric Association,
DOI: 10.1176/appi.neuropsych.20220105.
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