What is it about?
Neuromodulation therapies are emerging that target neural and behavioral substrates of drug addiction. Whereas most previous clinical trials targeted the dorsolateral prefrontal cortex, accumulating data highlight the frontopolar cortex as a promising therapeutic target for transcranial brain stimulation in people with substance use disorders. This review provides converging pieces of evidence highlighting the importance of targeting the frontopolar area and tailoring the treatment according to interindividual variations in brain state/trait and electric field distribution patterns.
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Why is it important?
Our findings provides a framework for addiction treatment using targeted neuromodulation.
Perspectives
This work is a great example of collaboration between multiple labs across different institutions to provide converging evidence to support a treatment target.
Hamed Ekhtiari
Laureate Institute for Brain Research
Read the Original
This page is a summary of: Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment, American Journal of Psychiatry, November 2023, American Psychiatric Association,
DOI: 10.1176/appi.ajp.20221022.
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