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Proteins are frequently modified after synthesis through post-translational modifications (PTMs), which involve the addition or alteration of chemical groups on specific amino acids. These modifications can have a significant impact on protein function by affecting their activity, location within the cell, interactions with other proteins, and overall stability. PTMs are essential for regulating various cellular processes, but capturing these modifications accurately in protein structural studies is challenging. This review focuses on the role of PTMs in influencing protein structure and function, examines the frequency and representation of these modifications in the Protein Data Bank, and highlights examples that can serve as valuable references for researchers in structural biology and protein modeling.

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This page is a summary of: Post-translational modifications in the Protein Data Bank, Acta Crystallographica Section D Structural Biology, August 2024, International Union of Crystallography,
DOI: 10.1107/s2059798324007794.
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