What is it about?
By taking advantage of a metals ability to catalyse multiple mechanistically distinct processes, multifaceted catalysis, this work enable to direct synthesis of important compounds in a clean and efficient manner.
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Why is it important?
First multifaceted catalysis approach to the regioselective synthesis of highly substituted pyrroles from oximes and activated alkynes. This mild and flexible method takes advantage of a gold catalysts ability to activate multiple steps of the process, thus utilising the metal more efficiently.
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This page is a summary of: Gold-catalysed rearrangement of O-vinyl oximes for the synthesis of highly substituted pyrroles, Chemical Communications, January 2011, Royal Society of Chemistry,
DOI: 10.1039/c0cc04372a.
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Meet Our Authors section of Chem. Comm.
Our research was highlighted in the meet out authors section of Chemical Communications.
Link to full paper on research
Full reference: Ngwerume, S.; Lewis, W.; Camp, J. E. Development of a Gold-Multifaceted Catalysis Approach to the Synthesis of Highly Substituted Pyrroles: Mechanistic Insights via Huisgen Cycloaddition Studies. J. Org. Chem. 2013, 78, 920–934.
Link to related pyrrole synthesis from our group
Fullw reference: Ngwerume, S.; Camp, J. E. Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis. J. Org. Chem. 2010, 75, 6271–6274. Highlighted as an Editors’ Choice article on ChemInform. (2011), Editors' Choice: ChemInform 2/2011. ChemInform, 42: no. doi: 10.1002/chin.201190202.
Multifaceted catalysis approach to benzoxazoles
Full reference: Lester, R. P.; Camp, J. E.* Methods for the Direct Synthesis of Benzoxazoles from Halogenated Nitriles in Alcoholic Solvents. ACS Sustainable Chem. Eng. 2013, 1, 545-548.
Platinum-Catalysed Synthesis of Trichloroamidines
Full reference: Dunsford, J. J.; Camp, J. E.* Platinum-Catalysed Synthesis of Trichloroamidines. Tetrahedron Letters, 2013, 54, 4522–4523.
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